메뉴 건너뛰기




Volumn 12, Issue 3, 2013, Pages 191-204

TET proteins: On the frenetic hunt for new cytosine modifications

Author keywords

DNA methylation; Epigenetics; Hydroxymethylation; OGT; TET proteins

Indexed keywords

CYTOSINE; GENOMIC DNA; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PEPTIDES AND PROTEINS; PROTEIN TET1; PROTEIN TET2; PROTEIN TET3; RNA POLYMERASE II; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

EID: 84878425943     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/elt010     Document Type: Article
Times cited : (40)

References (103)
  • 1
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010;28:1057-68.
    • (2010) Nat Biotechnol , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 2
    • 79956330964 scopus 로고    scopus 로고
    • CpG islands and the regulation of transcription
    • Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev 2011;25:1010-22.
    • (2011) Genes Dev , vol.25 , pp. 1010-1022
    • Deaton, A.M.1    Bird, A.2
  • 4
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: many roads lead to Rome
    • Wu SC, Zhang Y. Active DNA demethylation: many roads lead to Rome. Nat RevMol Cell Biol 2010;11:607-20.
    • (2010) Nat RevMol Cell Biol , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 5
    • 79959990071 scopus 로고    scopus 로고
    • Regulation of mammalian DNA methyltransferases: a route to new mechanisms
    • Denis H, Ndlovu MN, Fuks F. Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBORep 2011;12:647-56.
    • (2011) EMBORep , vol.12 , pp. 647-656
    • Denis, H.1    Ndlovu, M.N.2    Fuks, F.3
  • 6
    • 43049105333 scopus 로고    scopus 로고
    • Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development
    • Patra SK, Patra A, Rizzi F, et al. Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development. CancerMetastasis Rev 2008;27:315-34.
    • (2008) CancerMetastasis Rev , vol.27 , pp. 315-334
    • Patra, S.K.1    Patra, A.2    Rizzi, F.3
  • 7
    • 79954464651 scopus 로고    scopus 로고
    • Dynamics of epigenetic modifications in leukemia
    • Uribesalgo I, Di Croce L. Dynamics of epigenetic modifications in leukemia. Brief Funct Genomics 2011;10: 18-29.
    • (2011) Brief Funct Genomics , vol.10 , pp. 18-29
    • Uribesalgo, I.1    Di Croce, L.2
  • 8
    • 34250317798 scopus 로고
    • A new pyrimidine base from bacteriophage nucleic acids
    • Wyatt GR, Cohen SS. A new pyrimidine base from bacteriophage nucleic acids. Nature 1952;170:1072-3.
    • (1952) Nature , vol.170 , pp. 1072-1073
    • Wyatt, G.R.1    Cohen, S.S.2
  • 9
    • 84858268701 scopus 로고    scopus 로고
    • Hydroxylation mediates chromatin demethylation
    • Tsukada Y. Hydroxylation mediates chromatin demethylation. J Biochem 2012;151:229-46.
    • (2012) J Biochem , vol.151 , pp. 229-246
    • Tsukada, Y.1
  • 10
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009;324:929-30.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 11
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009;324:930-5.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 12
    • 0037099537 scopus 로고    scopus 로고
    • LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
    • Ono R, Taki T, Taketani T, etal. LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res 2002;62:4075-80.
    • (2002) Cancer Res , vol.62 , pp. 4075-4080
    • Ono, R.1    Taki, T.2    Taketani, T.3
  • 13
    • 66749152204 scopus 로고    scopus 로고
    • Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids
    • Iyer LM, Tahiliani M, Rao A, et al. Prediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acids. CellCycle 2009; 8:1698-1710.
    • (2009) CellCycle , vol.8 , pp. 1698-1710
    • Iyer, L.M.1    Tahiliani, M.2    Rao, A.3
  • 14
    • 82955207588 scopus 로고    scopus 로고
    • Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation
    • Wu H, Zhang Y. Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev 2011;25:2436-52.
    • (2011) Genes Dev , vol.25 , pp. 2436-2452
    • Wu, H.1    Zhang, Y.2
  • 15
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell selfrenewal and inner cell mass specification
    • Ito S, D'Alessio AC, Taranova OV, et al. Role of Tet proteins in 5mC to 5hmC conversion, ES-cell selfrenewal and inner cell mass specification. Nature 2010;466: 1129-33.
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3
  • 16
    • 19744376088 scopus 로고    scopus 로고
    • Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa
    • Smiley JA, Kundracik M, Landfried DA, et al. Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa. Biochim Biophys Acta 2005; 1723:256-64.
    • (2005) Biochim Biophys Acta , vol.1723 , pp. 256-264
    • Smiley, J.A.1    Kundracik, M.2    Landfried, D.A.3
  • 17
    • 67649974073 scopus 로고    scopus 로고
    • Cloning and characterization of Rhodotorula glutinis thymine hydroxylase
    • Neidigh JW, Darwanto A, Williams AA, et al. Cloning and characterization of Rhodotorula glutinis thymine hydroxylase. Chem ResToxicol 2009;22:885-93.
    • (2009) Chem ResToxicol , vol.22 , pp. 885-893
    • Neidigh, J.W.1    Darwanto, A.2    Williams, A.A.3
  • 18
    • 80052461558 scopus 로고    scopus 로고
    • Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
    • Ito S, Shen L, Dai Q, et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011;333:1300-3.
    • (2011) Science , vol.333 , pp. 1300-1303
    • Ito, S.1    Shen, L.2    Dai, Q.3
  • 19
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He YF, Li BZ, Li Z, et al. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011;333:1303-7.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.F.1    Li, B.Z.2    Li, Z.3
  • 20
    • 78650826181 scopus 로고    scopus 로고
    • Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
    • Globisch D, Munzel M, Muller M, et al. Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One 2010;5:e15367.
    • (2010) PLoS One , vol.5
    • Globisch, D.1    Munzel, M.2    Muller, M.3
  • 21
    • 78049401678 scopus 로고    scopus 로고
    • Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
    • Szwagierczak A, Bultmann S, Schmidt CS, et al. Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Res 2010;38:e181.
    • (2010) Nucleic Acids Res , vol.38
    • Szwagierczak, A.1    Bultmann, S.2    Schmidt, C.S.3
  • 22
    • 84857891830 scopus 로고    scopus 로고
    • Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes
    • Nestor CE, Ottaviano R, Reddington J, et al. Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes. Genome Res 2012;22:467-77.
    • (2012) Genome Res , vol.22 , pp. 467-477
    • Nestor, C.E.1    Ottaviano, R.2    Reddington, J.3
  • 23
    • 84864677516 scopus 로고    scopus 로고
    • Epigenetics: judge, jury and executioner of stem cell fate
    • Tollervey JR, Lunyak VV. Epigenetics: judge, jury and executioner of stem cell fate. Epigenetics 2012;7:823-40.
    • (2012) Epigenetics , vol.7 , pp. 823-840
    • Tollervey, J.R.1    Lunyak, V.V.2
  • 24
    • 84856058152 scopus 로고    scopus 로고
    • Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
    • Haffner MC, Chaux A, Meeker AK, et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget 2011;2:627-37.
    • (2011) Oncotarget , vol.2 , pp. 627-637
    • Haffner, M.C.1    Chaux, A.2    Meeker, A.K.3
  • 25
    • 84255200412 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
    • Jin SG, Jiang Y, Qiu R, et al. 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res 2011;71: 7360-5.
    • (2011) Cancer Res , vol.71 , pp. 7360-7365
    • Jin, S.G.1    Jiang, Y.2    Qiu, R.3
  • 26
    • 84863042219 scopus 로고    scopus 로고
    • Biochemical characterization of recombinant beta-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes
    • Terragni J, Bitinaite J, Zheng Y, et al. Biochemical characterization of recombinant beta-glucosyltransferase and analysis of global 5-hydroxymethylcytosine in unique genomes. Biochemistry 2012;51:1009-19.
    • (2012) Biochemistry , vol.51 , pp. 1009-1019
    • Terragni, J.1    Bitinaite, J.2    Zheng, Y.3
  • 27
    • 79952749156 scopus 로고    scopus 로고
    • DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
    • Shock LS, Thakkar PV, Peterson EJ, et al. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. ProcNatlAcad Sci USA 2011;108:3630-5.
    • (2011) ProcNatlAcad Sci USA , vol.108 , pp. 3630-3635
    • Shock, L.S.1    Thakkar, P.V.2    Peterson, E.J.3
  • 28
    • 84864463125 scopus 로고    scopus 로고
    • Effect of valproic acid on mitochondrial epigenetics
    • Chen H, Dzitoyeva S, Manev H. Effect of valproic acid on mitochondrial epigenetics. EurJ Pharmacol 2012;690:51-9.
    • (2012) EurJ Pharmacol , vol.690 , pp. 51-59
    • Chen, H.1    Dzitoyeva, S.2    Manev, H.3
  • 29
    • 84866755324 scopus 로고    scopus 로고
    • Effect of aging on 5-hydroxymethylcytosine in brain mitochondria
    • Dzitoyeva S, Chen H, Manev H. Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol Aging 2012;33:2881-91.
    • (2012) Neurobiol Aging , vol.33 , pp. 2881-2891
    • Dzitoyeva, S.1    Chen, H.2    Manev, H.3
  • 30
    • 84872770694 scopus 로고    scopus 로고
    • Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
    • Hackett JA, Sengupta R, Zylicz JJ, et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 2012;339:448-52.
    • (2012) Science , vol.339 , pp. 448-452
    • Hackett, J.A.1    Sengupta, R.2    Zylicz, J.J.3
  • 31
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 2007;447:425-32.
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 32
    • 79952763586 scopus 로고    scopus 로고
    • Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine
    • Iqbal K, Jin SG, Pfeifer GP, et al. Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A 2011;108:3642-7.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 3642-3647
    • Iqbal, K.1    Jin, S.G.2    Pfeifer, G.P.3
  • 33
    • 79952713567 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming
    • Wossidlo M, Nakamura T, Lepikhov K, et al. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun 2011; 2:241.
    • (2011) Nat Commun , vol.2 , pp. 241
    • Wossidlo, M.1    Nakamura, T.2    Lepikhov, K.3
  • 34
    • 80053348585 scopus 로고    scopus 로고
    • The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
    • Gu TP, Guo F, Yang H, et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 2011;477:606-10.
    • (2011) Nature , vol.477 , pp. 606-610
    • Gu, T.P.1    Guo, F.2    Yang, H.3
  • 35
    • 82655187105 scopus 로고    scopus 로고
    • Generation and replicationdependent dilution of 5fC and 5caC during mouse preimplantation development
    • Inoue A, Shen L, Dai Q, et al. Generation and replicationdependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res 2011;21:1670-6.
    • (2011) Cell Res , vol.21 , pp. 1670-1676
    • Inoue, A.1    Shen, L.2    Dai, Q.3
  • 36
    • 80054097425 scopus 로고    scopus 로고
    • Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos
    • Inoue A, Zhang Y. Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science 2011;334:194.
    • (2011) Science , vol.334 , pp. 194
    • Inoue, A.1    Zhang, Y.2
  • 37
    • 84862551364 scopus 로고    scopus 로고
    • PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos
    • Nakamura T, Liu YJ, Nakashima H, et al. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature 2012;486:415-9.
    • (2012) Nature , vol.486 , pp. 415-419
    • Nakamura, T.1    Liu, Y.J.2    Nakashima, H.3
  • 38
    • 0033580326 scopus 로고    scopus 로고
    • A mammalian protein with specific demethylase activity for mCpG DNA
    • Bhattacharya SK, Ramchandani S, Cervoni N, et al. A mammalian protein with specific demethylase activity for mCpG DNA. Nature 1999;397:579-83.
    • (1999) Nature , vol.397 , pp. 579-583
    • Bhattacharya, S.K.1    Ramchandani, S.2    Cervoni, N.3
  • 39
    • 58549092574 scopus 로고    scopus 로고
    • DNA repair deficiency and neurological disease
    • McKinnon PJ. DNA repair deficiency and neurological disease. Nat Rev Neurosci 2009;10:100-12.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 100-112
    • Mckinnon, P.J.1
  • 40
    • 33846933274 scopus 로고    scopus 로고
    • Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    • Barreto G, Schafer A, Marhold J, et al. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation. Nature 2007;445:671-5.
    • (2007) Nature , vol.445 , pp. 671-675
    • Barreto, G.1    Schafer, A.2    Marhold, J.3
  • 41
    • 77950443318 scopus 로고    scopus 로고
    • NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack
    • Le May N, Mota-Fernandes D, Velez-Cruz R, et al. NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol Cell 2010;38:54-66.
    • (2010) Mol Cell , vol.38 , pp. 54-66
    • Le May, N.1    Mota-Fernandes, D.2    Velez-Cruz, R.3
  • 42
    • 59849090498 scopus 로고    scopus 로고
    • TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation
    • Schmitz KM, Schmitt N, Hoffmann-Rohrer U, et al. TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. Mol Cell 2009;33: 344-53.
    • (2009) Mol Cell , vol.33 , pp. 344-53
    • Schmitz, K.M.1    Schmitt, N.2    Hoffmann-Rohrer, U.3
  • 43
    • 79959937861 scopus 로고    scopus 로고
    • Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
    • Cortellino S, Xu J, Sannai M, et al. Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 2011;146:67-79.
    • (2011) Cell , vol.146 , pp. 67-79
    • Cortellino, S.1    Xu, J.2    Sannai, M.3
  • 44
    • 57649196594 scopus 로고    scopus 로고
    • DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45
    • Rai K, Huggins IJ, James SR, et al. DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell 2008;135:1201-12.
    • (2008) Cell , vol.135 , pp. 1201-1012
    • Rai, K.1    Huggins, I.J.2    James, S.R.3
  • 45
    • 84860378636 scopus 로고    scopus 로고
    • Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity
    • Freudenberg JM, Ghosh S, Lackford BL, et al. Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity. Nucleic Acids Res 2012;40: 3364-77.
    • (2012) Nucleic Acids Res , vol.40 , pp. 3364-3377
    • Freudenberg, J.M.1    Ghosh, S.2    Lackford, B.L.3
  • 46
    • 79956292024 scopus 로고    scopus 로고
    • Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
    • Wu H, D'Alessio AC, Ito S, et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 2011;473:389-93.
    • (2011) Nature , vol.473 , pp. 389-393
    • Wu, H.1    D'Alessio, A.C.2    Ito, S.3
  • 47
    • 79961139741 scopus 로고    scopus 로고
    • Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
    • Dawlaty MM, Ganz K, Powell BE, et al. Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell StemCell 2011; 9:166-75.
    • (2011) Cell StemCell , vol.9 , pp. 166-175
    • Dawlaty, M.M.1    Ganz, K.2    Powell, B.E.3
  • 48
    • 84865486793 scopus 로고    scopus 로고
    • Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2
    • Doege CA, Inoue K, Yamashita T, etal. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 2012;488:652-5.
    • (2012) Nature , vol.488 , pp. 652-655
    • Doege, C.A.1    Inoue, K.2    Yamashita, T.3
  • 49
    • 79956323623 scopus 로고    scopus 로고
    • Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
    • Ficz G, Branco MR, Seisenberger S, et al. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature 2011;473:398-402.
    • (2011) Nature , vol.473 , pp. 398-402
    • Ficz, G.1    Branco, M.R.2    Seisenberger, S.3
  • 50
    • 79551587102 scopus 로고    scopus 로고
    • Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
    • Koh KP, Yabuuchi A, Rao S, et al. Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 2011;8:200-13.
    • (2011) Cell Stem Cell , vol.8 , pp. 200-213
    • Koh, K.P.1    Yabuuchi, A.2    Rao, S.3
  • 51
    • 79956302047 scopus 로고    scopus 로고
    • TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
    • Williams K, Christensen J, Pedersen MT, et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 2011;473:343-8.
    • (2011) Nature , vol.473 , pp. 343-348
    • Williams, K.1    Christensen, J.2    Pedersen, M.T.3
  • 52
    • 79955948324 scopus 로고    scopus 로고
    • Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
    • Xu Y, Wu F, Tan L, et al. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell 2011;42:451-64.
    • (2011) Mol Cell , vol.42 , pp. 451-464
    • Xu, Y.1    Wu, F.2    Tan, L.3
  • 53
    • 84866847877 scopus 로고    scopus 로고
    • Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome
    • Thomson JP, Lempiainen H, Hackett JA, et al. Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome. Genome Biol 2012;13: R93.
    • (2012) Genome Biol , vol.13
    • Thomson, J.P.1    Lempiainen, H.2    Hackett, J.A.3
  • 54
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo JU, Su Y, Zhong C, et al. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 2011;145:423-34.
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3
  • 55
    • 84876718688 scopus 로고    scopus 로고
    • The role of activation-induced deaminase in antibody diversification and genomic instability
    • Wang JH. The role of activation-induced deaminase in antibody diversification and genomic instability. Immunol Res 2013;55:287-97.
    • (2013) Immunol Res , vol.55 , pp. 287-297
    • Wang, J.H.1
  • 56
    • 0021054081 scopus 로고
    • Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation
    • Storb U, Arp B. Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation. Proc Natl Acad Sci USA 1983;80:6642-6.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6642-6646
    • Storb, U.1    Arp, B.2
  • 57
    • 0033511194 scopus 로고    scopus 로고
    • Molecular aspects of somatic hypermutation of immunoglobulin genes
    • Storb U, Peters A, Kim N, et al. Molecular aspects of somatic hypermutation of immunoglobulin genes. Cold SpringHarb Symp Quant Biol 1999;64:227-34.
    • (1999) Cold SpringHarb Symp Quant Biol , vol.64 , pp. 227-234
    • Storb, U.1    Peters, A.2    Kim, N.3
  • 58
    • 77749277177 scopus 로고    scopus 로고
    • The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
    • Huang Y, Pastor WA, Shen Y, et al. The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One 2010;5:e8888.
    • (2010) PLoS One , vol.5
    • Huang, Y.1    Pastor, W.A.2    Shen, Y.3
  • 59
    • 84869392308 scopus 로고    scopus 로고
    • Mapping recently identified nucleotide variants in the genome and transcriptome
    • Song CX, Yi C, He C. Mapping recently identified nucleotide variants in the genome and transcriptome. NatBiotechnol 2012;30:1107-16.
    • (2012) NatBiotechnol , vol.30 , pp. 1107-1116
    • Song, C.X.1    Yi, C.2    He, C.3
  • 60
    • 79959209733 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
    • Stroud H, Feng S, Morey Kinney S, et al. 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol 2011;12:R54.
    • (2011) Genome Biol , vol.12
    • Stroud, H.1    Feng, S.2    Morey Kinney, S.3
  • 61
    • 79956308473 scopus 로고    scopus 로고
    • Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
    • Pastor WA, Pape UJ, Huang Y, et al. Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 2011;473:394-7.
    • (2011) Nature , vol.473 , pp. 394-397
    • Pastor, W.A.1    Pape, U.J.2    Huang, Y.3
  • 62
    • 84861990517 scopus 로고    scopus 로고
    • Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome
    • Yu M, Hon GC, Szulwach KE, et al. Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell 2012;149:1368-80.
    • (2012) Cell , vol.149 , pp. 1368-1380
    • Yu, M.1    Hon, G.C.2    Szulwach, K.E.3
  • 63
    • 70450217879 scopus 로고    scopus 로고
    • Human DNA methylomes at base resolution show widespread epigenomic differences
    • Lister R, Pelizzola M, Dowen RH, et al. Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 2009;462:315-22.
    • (2009) Nature , vol.462 , pp. 315-322
    • Lister, R.1    Pelizzola, M.2    Dowen, R.H.3
  • 64
    • 84865061978 scopus 로고    scopus 로고
    • Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
    • Raiber EA, Beraldi D, Ficz G, et al. Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase. Genome Biol 2012;13:R69.
    • (2012) Genome Biol , vol.13
    • Raiber, E.A.1    Beraldi, D.2    Ficz, G.3
  • 65
    • 80455176999 scopus 로고    scopus 로고
    • CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
    • Shukla S, Kavak E, Gregory M, et al. CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature 2011;479:74-9.
    • (2011) Nature , vol.479 , pp. 74-79
    • Shukla, S.1    Kavak, E.2    Gregory, M.3
  • 66
    • 84864553255 scopus 로고    scopus 로고
    • Pre-mRNA splicing: role of epigenetics and implications in disease
    • Khan DH, Jahan S, Davie JR. Pre-mRNA splicing: role of epigenetics and implications in disease. Adv BiolRegul 2012; 52:377-88.
    • (2012) Adv BiolRegul , vol.52 , pp. 377-388
    • Khan, D.H.1    Jahan, S.2    Davie, J.R.3
  • 67
    • 84869016883 scopus 로고    scopus 로고
    • New functions for DNA modifications by TET-JBP
    • Huang Y, Rao A. New functions for DNA modifications by TET-JBP. Nat StructMol Biol 2012;19:1061-4.
    • (2012) Nat StructMol Biol , vol.19 , pp. 1061-1064
    • Huang, Y.1    Rao, A.2
  • 68
    • 84867230056 scopus 로고    scopus 로고
    • 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
    • Khare T, Pai S, Koncevicius K, et al. 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nat Struct Mol Biol 2012;19: 1037-43.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 1037-1043
    • Khare, T.1    Pai, S.2    Koncevicius, K.3
  • 69
    • 84864722177 scopus 로고    scopus 로고
    • 5-Formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription
    • Kellinger MW, Song CX, Chong J, et al. 5-Formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription. Nat Struct Mol Biol 2012;19:831-3.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 831-833
    • Kellinger, M.W.1    Song, C.X.2    Chong, J.3
  • 70
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan Q, Shai O, Lee LJ, et al. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008;40:1413-5.
    • (2008) Nat Genet , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3
  • 71
    • 84863481799 scopus 로고    scopus 로고
    • Defects in spliceosomal machinery: a new pathway of leukaemogenesis
    • Maciejewski JP, Padgett RA. Defects in spliceosomal machinery: a new pathway of leukaemogenesis. Br J Haematol 2012;158:165-73.
    • (2012) Br J Haematol , vol.158 , pp. 165-173
    • Maciejewski, J.P.1    Padgett, R.A.2
  • 72
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song CX, Szulwach KE, Fu Y, et al. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 2011;29:68-72.
    • (2011) Nat Biotechnol , vol.29 , pp. 68-72
    • Song, C.X.1    Szulwach, K.E.2    Fu, Y.3
  • 73
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    • Szulwach KE, Li X, Li Y, et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. NatNeurosci 2011;14:1607-16.
    • (2011) NatNeurosci , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1    Li, X.2    Li, Y.3
  • 74
    • 84858976475 scopus 로고    scopus 로고
    • Epigenetic features are significantly associated with alternative splicing
    • Zhou Y, Lu Y, Tian W. Epigenetic features are significantly associated with alternative splicing. BMCGenomics 2012;13: 123.
    • (2012) BMCGenomics , vol.13 , pp. 123
    • Zhou, Y.1    Lu, Y.2    Tian, W.3
  • 75
    • 84875218124 scopus 로고    scopus 로고
    • TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
    • Epub ahead of print.
    • Deplus R, Delatte B, Schwinn MK, et al. TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. EMBO J 2013; Epub ahead of print.
    • (2013) EMBO J
    • Deplus, R.1    Delatte, B.2    Schwinn, M.K.3
  • 76
    • 84860184939 scopus 로고    scopus 로고
    • Bittersweet memories linking metabolism to epigenetics through O-GlcNAcylation
    • Hanover JA, Krause MW, Love DC. Bittersweet memories linking metabolism to epigenetics through O-GlcNAcylation.Nat RevMol Cell Biol 2012;13:312-21.
    • (2012) Nat RevMol Cell Biol , vol.13 , pp. 312-321
    • Hanover, J.A.1    Krause, M.W.2    Love, D.C.3
  • 77
    • 84872953223 scopus 로고    scopus 로고
    • TET2 promotes histone O-GlcNAcylation during gene transcription
    • Chen Q, Chen Y, Bian C, et al. TET2 promotes histone O-GlcNAcylation during gene transcription. Nature 2013; 493:561-4.
    • (2013) Nature , vol.493 , pp. 561-564
    • Chen, Q.1    Chen, Y.2    Bian, C.3
  • 78
    • 84355161950 scopus 로고    scopus 로고
    • GlcNAcylation of histone H2B facilitates its monoubiquitination
    • Fujiki R, Hashiba W, Sekine H, et al. GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature 2011;480:557-60.
    • (2011) Nature , vol.480 , pp. 557-560
    • Fujiki, R.1    Hashiba, W.2    Sekine, H.3
  • 79
    • 57349124451 scopus 로고    scopus 로고
    • Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS
    • Wu M, Wang PF, Lee JS, et al. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol 2008;28:7337-44.
    • (2008) Mol Cell Biol , vol.28 , pp. 7337-7344
    • Wu, M.1    Wang, P.F.2    Lee, J.S.3
  • 80
    • 79959431845 scopus 로고    scopus 로고
    • Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain
    • Frauer C, Hoffmann T, Bultmann S, et al. Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain. PLoS One 2011;6:e21306.
    • (2011) PLoS One , vol.6
    • Frauer, C.1    Hoffmann, T.2    Bultmann, S.3
  • 81
    • 84455167621 scopus 로고    scopus 로고
    • Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
    • Yildirim O, Li R, Hung JH, et al. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 2011;147: 1498-510.
    • (2011) Cell , vol.147 , pp. 1498-510
    • Yildirim, O.1    Li, R.2    Hung, J.H.3
  • 82
    • 84871563384 scopus 로고    scopus 로고
    • MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system
    • Mellén M, Ayata P, Dewell S, et al. MeCP2 binds to 5hmC enriched within active genes and accessible chromatin in the nervous system. Cell 2012;151:1417-1430.
    • (2012) Cell , vol.151 , pp. 1417-1430
    • Mellén, M.1    Ayata, P.2    Dewell, S.3
  • 83
    • 84855303734 scopus 로고    scopus 로고
    • Epigenetics in disease and cancer
    • Choo KB. Epigenetics in disease and cancer. MalaysJ Pathol 2011;33:61-70.
    • (2011) MalaysJ Pathol , vol.33 , pp. 61-70
    • Choo, K.B.1
  • 85
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian CG, Xu Y, Ceol C, et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 2012;150:1135-46.
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1    Xu, Y.2    Ceol, C.3
  • 86
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • Shih AH, Abdel-Wahab O, Patel JP, et al. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer 2012;12:599-612.
    • (2012) Nat Rev Cancer , vol.12 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3
  • 87
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • Tefferi A, Pardanani A, Lim KH, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009;23: 905-11.
    • (2009) Leukemia , vol.23 , pp. 905-11
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 88
    • 79959794787 scopus 로고    scopus 로고
    • Clinical effect of point mutations in myelodysplastic syndromes
    • Bejar R, Stevenson K, Abdel-Wahab O, etal. Clinical effect of point mutations in myelodysplastic syndromes. N EnglJ Med 2011;364:2496-506.
    • (2011) N EnglJ Med , vol.364 , pp. 2496-2506
    • Bejar, R.1    Stevenson, K.2    Abdel-Wahab, O.3
  • 89
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, etal. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. NEnglJMed 2012;366:1079-89.
    • (2012) NEnglJMed , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 90
    • 80052285127 scopus 로고    scopus 로고
    • Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
    • Li Z, Cai X, Cai CL, et al. Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies. Blood 2011;118: 4509-18.
    • (2011) Blood , vol.118 , pp. 4509-4518
    • Li, Z.1    Cai, X.2    Cai, C.L.3
  • 91
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio K, Reavie L, Shih A, et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell 2011;20:11-24.
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1    Reavie, L.2    Shih, A.3
  • 92
    • 79960062301 scopus 로고    scopus 로고
    • TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    • Quivoron C, Couronne L, Della Valle V, et al. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell 2011;20:25-38.
    • (2011) Cancer Cell , vol.20 , pp. 25-38
    • Quivoron, C.1    Couronne, L.2    Della Valle, V.3
  • 93
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 2010;18:553-67.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 94
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • Ko M, Huang Y, Jankowska AM, et al. Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 2010;468:839-43.
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.M.3
  • 95
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009;462: 739-44.
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 96
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 2010;17:225-34.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 97
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alphaketoglutarate- dependent dioxygenases
    • Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alphaketoglutarate- dependent dioxygenases. Cancer Cell 2011; 19:17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3
  • 98
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, etal. Recurring mutations found by sequencing an acute myeloid leukemia genome. NEnglJMed 2009;361:1058-66.
    • (2009) NEnglJMed , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 99
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study
    • Marcucci G, Maharry K, Wu YZ, et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2010;28: 2348-55.
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 100
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • Tefferi A, Lasho TL, Abdel-Wahab O, et al. IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis. Leukemia 2010;24: 1302-1309.
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3
  • 101
    • 84857997263 scopus 로고    scopus 로고
    • IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F
    • Tefferi A, Jimma T, Sulai NH, et al. IDH mutations in primary myelofibrosis predict leukemic transformation and shortened survival: clinical evidence for leukemogenic collaboration with JAK2V617F. Leukemia 2012;26: 475-80.
    • (2012) Leukemia , vol.26 , pp. 475-480
    • Tefferi, A.1    Jimma, T.2    Sulai, N.H.3
  • 102
    • 33847055935 scopus 로고    scopus 로고
    • Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1
    • Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 2007; 67:946-50.
    • (2007) Cancer Res , vol.67 , pp. 946-950
    • Valinluck, V.1    Sowers, L.C.2
  • 103
    • 84862681459 scopus 로고    scopus 로고
    • Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing
    • Schiesser S, Hackner B, Pfaffeneder T, et al. Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing. Angew Chem Int Ed Engl 2012;51:6516-20.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 6516-6520
    • Schiesser, S.1    Hackner, B.2    Pfaffeneder, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.