-
1
-
-
84875354777
-
2013 Alzheimers disease facts and figures. Alzheimers Association Report
-
Thies, W.; Bleiler, L. 2013 Alzheimers disease facts and figures. Alzheimers Association Report Alzheimers Dementia 2013, 9, 208-245
-
(2013)
Alzheimers Dementia
, vol.9
, pp. 208-245
-
-
Thies, W.1
Bleiler, L.2
-
2
-
-
84929587593
-
-
http://investor.frx.com/press-release/product-news/fda-approves-namendatm-memantine-hcl-treatment-moderate-severe-alzheimers.
-
-
-
-
3
-
-
84903947419
-
Alzheimers disease drug-development pipeline: Few candidates, frequent failure
-
Cummings, J. L.; Travis, M.; Zhong, K. Alzheimers disease drug-development pipeline: Few candidates, frequent failure Alzheimers Res. Ther. 2014, 6, 37-43
-
(2014)
Alzheimers Res. Ther.
, vol.6
, pp. 37-43
-
-
Cummings, J.L.1
Travis, M.2
Zhong, K.3
-
4
-
-
84925564551
-
Why are drug trials in Alzheimers disease failing?
-
The Lancet
-
The Lancet Why are drug trials in Alzheimers disease failing? Lancet 2010, 376, 658-658
-
(2010)
Lancet
, vol.376
, pp. 658-658
-
-
-
5
-
-
77953518555
-
Alzheimers disease: Clinical trials and drug development
-
Mangialasche, F.; Solomon, A.; Winblad, B.; Mecocci, P.; Kivipelto, M. Alzheimers disease: Clinical trials and drug development Lancet Neurol. 2010, 9, 702-716
-
(2010)
Lancet Neurol.
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
6
-
-
84884852756
-
Metallostasis in Alzheimers disease
-
Ayton, S.; Lei, P.; Bush, A. I. Metallostasis in Alzheimers disease Free Radical Biol. Med. 2013, 62, 76-89
-
(2013)
Free Radical Biol. Med.
, vol.62
, pp. 76-89
-
-
Ayton, S.1
Lei, P.2
Bush, A.I.3
-
7
-
-
77950617631
-
A mouse model of amyloid β oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo
-
Tomiyama, T.; Matsuyama, S.; Iso, H.; Umeda, T.; Takuma, H.; Ohnishi, K.; Ishibashi, K.; Teraoka, R.; Sakama, N.; Yamashita, T.; Nishitsuji, K.; Ito, K.; Shimada, H.; Lambert, M. P.; Klein, W. L.; Mori, H. A mouse model of amyloid β oligomers: Their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo J. Neurosci. 2010, 30, 4845-4856
-
(2010)
J. Neurosci.
, vol.30
, pp. 4845-4856
-
-
Tomiyama, T.1
Matsuyama, S.2
Iso, H.3
Umeda, T.4
Takuma, H.5
Ohnishi, K.6
Ishibashi, K.7
Teraoka, R.8
Sakama, N.9
Yamashita, T.10
Nishitsuji, K.11
Ito, K.12
Shimada, H.13
Lambert, M.P.14
Klein, W.L.15
Mori, H.16
-
8
-
-
84871747365
-
Alzheimers disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats
-
Zussy, C.; Brureau, A.; Keller, E.; Marchal, S.; Blayo, C.; Delair, B.; Ixart, G.; Maurice, T.; Givalois, L. Alzheimers disease related markers, cellular toxicity and behavioral deficits induced six weeks after oligomeric amyloid-β peptide injection in rats PLoS One 2013, 8 e53117
-
(2013)
PLoS One
, vol.8
, pp. 53117
-
-
Zussy, C.1
Brureau, A.2
Keller, E.3
Marchal, S.4
Blayo, C.5
Delair, B.6
Ixart, G.7
Maurice, T.8
Givalois, L.9
-
9
-
-
0346106076
-
Metal binding and oxidation of amyloid-β within isolated senile plaques cores: Raman microscopic evidence
-
Dong, J.; Atwood, C. S.; Anderson, V. E.; Siedlak, S. L.; Smith, M. A.; Perry, G.; Carey, P. R. Metal binding and oxidation of amyloid-β within isolated senile plaques cores: Raman microscopic evidence Biochemistry 2003, 42, 2768-2773
-
(2003)
Biochemistry
, vol.42
, pp. 2768-2773
-
-
Dong, J.1
Atwood, C.S.2
Anderson, V.E.3
Siedlak, S.L.4
Smith, M.A.5
Perry, G.6
Carey, P.R.7
-
10
-
-
34547414064
-
Redox chemistry of copper-amyloid-β: The generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state
-
Guilloreau, L.; Combalbert, S.; Sournia-Saquet, A.; Mazarguil, H.; Faller, P. Redox chemistry of copper-amyloid-β: The generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state ChemBioChem 2007, 8, 1317-1325
-
(2007)
ChemBioChem
, vol.8
, pp. 1317-1325
-
-
Guilloreau, L.1
Combalbert, S.2
Sournia-Saquet, A.3
Mazarguil, H.4
Faller, P.5
-
11
-
-
34547914869
-
Redox reaction of copper complexes formed with different β-amyloid peptides and their neuropathological relevance
-
Jiang, D.; Men, L.; Wang, J.; Zhang, Y.; Chickenyen, S.; Wang, Y.; Zhou, F. Redox reaction of copper complexes formed with different β-amyloid peptides and their neuropathological relevance Biochemistry 2007, 46, 9270-9282
-
(2007)
Biochemistry
, vol.46
, pp. 9270-9282
-
-
Jiang, D.1
Men, L.2
Wang, J.3
Zhang, Y.4
Chickenyen, S.5
Wang, Y.6
Zhou, F.7
-
12
-
-
12144257164
-
NMDA receptor activation mediates copper homeostasis in hippocampal neurons
-
Schlief, M. L.; Craig, A. M.; Gitlin, J. D. NMDA receptor activation mediates copper homeostasis in hippocampal neurons J. Neurosci. 2005, 25, 239-246
-
(2005)
J. Neurosci.
, vol.25
, pp. 239-246
-
-
Schlief, M.L.1
Craig, A.M.2
Gitlin, J.D.3
-
13
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces Aβ production in APP23 transgenic mice
-
Bayer, T. A.; Schäfer, S.; Simons, A.; Kemmling, A.; Kamer, T.; Tepest, R.; Eckert, A.; Schüssel, K.; Eikenberg, O.; Sturchler-Pierrat, C.; Abramowski, D.; Staufenbiel, M.; Multhaup, G. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces Aβ production in APP23 transgenic mice Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14187-14192
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schäfer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schüssel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
14
-
-
80051658907
-
Brain iron metabolism and its perturbation in neurological diseases
-
Crichton, R. R.; Dexter, D. T.; Ward, R. J. Brain iron metabolism and its perturbation in neurological diseases J. Neural Transm. 2011, 118, 301-314
-
(2011)
J. Neural Transm.
, vol.118
, pp. 301-314
-
-
Crichton, R.R.1
Dexter, D.T.2
Ward, R.J.3
-
15
-
-
80052758497
-
Iron(II) binding to amyloid-β, the Alzheimers peptide
-
Bousejra-ElGarah, F.; Bijani, C.; Coppel, Y.; Faller, P.; Hureau, C. Iron(II) binding to amyloid-β, the Alzheimers peptide Inorg. Chem. 2011, 50, 9024-9030
-
(2011)
Inorg. Chem.
, vol.50
, pp. 9024-9030
-
-
Bousejra-Elgarah, F.1
Bijani, C.2
Coppel, Y.3
Faller, P.4
Hureau, C.5
-
16
-
-
84872288882
-
Zn impact Cu coordination to amyloid-β, the Alzheimers peptide, but not the ROS production and the associated cell toxicity
-
Aliès, B.; Sasaki, I.; Proux, O.; Sayen, S.; Guillon, E.; Faller, P.; Hureau, C. Zn impact Cu coordination to amyloid-β, the Alzheimers peptide, but not the ROS production and the associated cell toxicity Chem. Commun. 2013, 49, 1214-1216
-
(2013)
Chem. Commun.
, vol.49
, pp. 1214-1216
-
-
Aliès, B.1
Sasaki, I.2
Proux, O.3
Sayen, S.4
Guillon, E.5
Faller, P.6
Hureau, C.7
-
17
-
-
59449101792
-
Restored degradation of the Alzheimers amyloid-β peptide by targeting amyloid formation
-
Crouch, P. J.; Tew, D. J.; Du, T.; Nguyen, D. N.; Caragounis, A.; Filiz, G.; Blake, R. E.; Trounce, I. A.; Soon, C. P. W.; Laughton, K.; Perez, K. A.; Li, Q.-X.; Cherny, R. A.; Masters, C. L.; Barnham, K. J.; White, A. R. Restored degradation of the Alzheimers amyloid-β peptide by targeting amyloid formation J. Neurochem. 2009, 108, 1198-1207
-
(2009)
J. Neurochem.
, vol.108
, pp. 1198-1207
-
-
Crouch, P.J.1
Tew, D.J.2
Du, T.3
Nguyen, D.N.4
Caragounis, A.5
Filiz, G.6
Blake, R.E.7
Trounce, I.A.8
Soon, C.P.W.9
Laughton, K.10
Perez, K.A.11
Li, Q.-X.12
Cherny, R.A.13
Masters, C.L.14
Barnham, K.J.15
White, A.R.16
-
18
-
-
77956647381
-
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimers disease
-
Duce, J. A.; Tsatsanis, A.; Cater, M. A.; James, S. A.; Robb, E.; Wikhe, K.; Leong, S. L.; Perez, K.; Johanssen, T.; Greenough, M. A.; Cho, H. H.; Galatis, D.; Moir, R. D.; Masters, C. L.; McLean, C.; Tanzi, R. E.; Cappai, R.; Barnham, K. J.; Ciccotosto, G. D.; Rogers, J. T.; Bush, A. I. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimers disease Cell 2010, 142, 857-867
-
(2010)
Cell
, vol.142
, pp. 857-867
-
-
Duce, J.A.1
Tsatsanis, A.2
Cater, M.A.3
James, S.A.4
Robb, E.5
Wikhe, K.6
Leong, S.L.7
Perez, K.8
Johanssen, T.9
Greenough, M.A.10
Cho, H.H.11
Galatis, D.12
Moir, R.D.13
Masters, C.L.14
McLean, C.15
Tanzi, R.E.16
Cappai, R.17
Barnham, K.J.18
Ciccotosto, G.D.19
Rogers, J.T.20
Bush, A.I.21
more..
-
19
-
-
84870481575
-
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
-
Xiong, Y.; Jing, X.-P.; Zhou, X.-W.; Wang, X.-L.; Yang, Y.; Sun, X. Y.; Qiu, M.; Cao, F. Y.; Lu, Y.-M.; Liu, R.; Wang, J.-Z. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation Neurobiol. Aging 2013, 34, 745-756
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 745-756
-
-
Xiong, Y.1
Jing, X.-P.2
Zhou, X.-W.3
Wang, X.-L.4
Yang, Y.5
Sun, X.Y.6
Qiu, M.7
Cao, F.Y.8
Lu, Y.-M.9
Liu, R.10
Wang, J.-Z.11
-
20
-
-
84907195362
-
Biological metals and metal-targeting compounds in major neurodegenerative diseases
-
Barnham, K. J.; Bush, A. I. Biological metals and metal-targeting compounds in major neurodegenerative diseases Chem. Soc. Rev. 2014, 43, 6727-6749
-
(2014)
Chem. Soc. Rev.
, vol.43
, pp. 6727-6749
-
-
Barnham, K.J.1
Bush, A.I.2
-
21
-
-
84872962290
-
Werner coordination chemistry and neurodegeneration
-
Telpoukhovskaia, M. A.; Orvig, C. Werner coordination chemistry and neurodegeneration Chem. Soc. Rev. 2013, 42, 1836-1846
-
(2013)
Chem. Soc. Rev.
, vol.42
, pp. 1836-1846
-
-
Telpoukhovskaia, M.A.1
Orvig, C.2
-
22
-
-
84870625593
-
A bioinorganic view of Alzheimers disease: When misplaced metal ions (re)direct the electrons to the wrong target
-
Faller, P.; Hureau, C. A bioinorganic view of Alzheimers disease: When misplaced metal ions (re)direct the electrons to the wrong target Chem.-Eur. J. 2012, 18, 15910-15920
-
(2012)
Chem.-Eur. J.
, vol.18
, pp. 15910-15920
-
-
Faller, P.1
Hureau, C.2
-
23
-
-
77149144132
-
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease
-
Perez, L. R.; Franz, K. J. Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease Dalton Trans. 2010, 39, 2177-2187
-
(2010)
Dalton Trans.
, vol.39
, pp. 2177-2187
-
-
Perez, L.R.1
Franz, K.J.2
-
24
-
-
84907999177
-
The role of iron in brain ageing and neurodegenerative disorders
-
Ward, R. J.; Zucca, F. A.; Duyn, J. H.; Crichton, R. R.; Zecca, L. The role of iron in brain ageing and neurodegenerative disorders Lancet Neurol. 2014, 13, 1045-1060
-
(2014)
Lancet Neurol.
, vol.13
, pp. 1045-1060
-
-
Ward, R.J.1
Zucca, F.A.2
Duyn, J.H.3
Crichton, R.R.4
Zecca, L.5
-
25
-
-
79551713201
-
Brain microbleeds and Alzheimers disease: Innocent observation or key player?
-
Cordonnier, C.; Van der Flier, W. M. Brain microbleeds and Alzheimers disease: Innocent observation or key player? Brain 2011, 134, 335-344
-
(2011)
Brain
, vol.134
, pp. 335-344
-
-
Cordonnier, C.1
Van Der Flier, W.M.2
-
26
-
-
84886872345
-
The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: Its time for reconciliation
-
Barone, E.; Di Domenico, F.; Mancuso, C.; Butterfield, D. A. The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: Its time for reconciliation Neurobiol. Dis. 2014, 62, 144-159
-
(2014)
Neurobiol. Dis.
, vol.62
, pp. 144-159
-
-
Barone, E.1
Di Domenico, F.2
Mancuso, C.3
Butterfield, D.A.4
-
27
-
-
84869080922
-
Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimers disease
-
Guo, C.; Wang, T.; Zheng, W.; Shan, Z.-Y.; Teng, W.-P.; Wang, Z.-Y. Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimers disease Neurobiol. Aging 2013, 34, 562-575
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 562-575
-
-
Guo, C.1
Wang, T.2
Zheng, W.3
Shan, Z.-Y.4
Teng, W.-P.5
Wang, Z.-Y.6
-
28
-
-
0037203975
-
Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: Structure-activity investigation of metalloenzyme inhibition by iron chelators
-
references therein
-
Liu, Z. D.; Kayyali, R.; Hidder, R. C.; Porter, J. B.; Theobald, A. E. Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: Structure-activity investigation of metalloenzyme inhibition by iron chelators J. Med. Chem. 2002, 45, 631-639 and references therein.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 631-639
-
-
Liu, Z.D.1
Kayyali, R.2
Hidder, R.C.3
Porter, J.B.4
Theobald, A.E.5
-
29
-
-
0000805076
-
Comparative iron binding studies of bis- and tris(3-hydroxy-2methylpyridin-4-ones) and deferrioxamine
-
Sheppard, L. N.; Kontoghiorghes, G. J. Comparative iron binding studies of bis- and tris(3-hydroxy-2methylpyridin-4-ones) and deferrioxamine Inorg. Chim. Acta 1991, 188, 177-183
-
(1991)
Inorg. Chim. Acta
, vol.188
, pp. 177-183
-
-
Sheppard, L.N.1
Kontoghiorghes, G.J.2
-
30
-
-
55849086189
-
Altering pyridone N -substituents to optimize activity as potential prodrugs for Alzheimers disease
-
Scott, L. E.; Page, B. D. G.; Patrick, B. O.; Orvig, C. Altering pyridone N -substituents to optimize activity as potential prodrugs for Alzheimers disease Dalton Trans. 2008, 6364-6367
-
(2008)
Dalton Trans.
, pp. 6364-6367
-
-
Scott, L.E.1
Page, B.D.G.2
Patrick, B.O.3
Orvig, C.4
-
31
-
-
76749124448
-
In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimers disease
-
Green, D. E.; Bowen, M. L.; Scott; Storr, T.; Merkel, M.; Böhlmerle, K.; Thompson, K. E.; Patrick, B. O.; Schugar, H. J.; Orvig, C. In vitro studies of 3-hydroxy-4-pyridinones and their glycosylated derivatives as potential agents for Alzheimers disease Dalton Trans. 2010, 39, 1604-1615
-
(2010)
Dalton Trans.
, vol.39
, pp. 1604-1615
-
-
Green, D.E.1
Bowen, M.L.2
Scott3
Storr, T.4
Merkel, M.5
Böhlmerle, K.6
Thompson, K.E.7
Patrick, B.O.8
Schugar, H.J.9
Orvig, C.10
-
32
-
-
0028266895
-
Copper complexation by 3-hydroxypyridin-4-one iron chelators: Structural and iron competition studies
-
El-Jammal, A.; Howell, P. L.; Turner, M. A.; Li, N.; Templeton, D. M. Copper complexation by 3-hydroxypyridin-4-one iron chelators: Structural and iron competition studies J. Med. Chem. 1994, 37, 461-466
-
(1994)
J. Med. Chem.
, vol.37
, pp. 461-466
-
-
El-Jammal, A.1
Howell, P.L.2
Turner, M.A.3
Li, N.4
Templeton, D.M.5
-
33
-
-
8844282620
-
Iron(III)-selective dendritic chelators
-
Zhou, T.; Hider, R. C.; Liu, Z. D.; Neubert, H. Iron(III)-selective dendritic chelators Tetrahedron Lett. 2004, 45, 9393-9396
-
(2004)
Tetrahedron Lett.
, vol.45
, pp. 9393-9396
-
-
Zhou, T.1
Hider, R.C.2
Liu, Z.D.3
Neubert, H.4
-
34
-
-
33748202940
-
Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance
-
Liu, G.; Men, P.; Harris, P. L. R.; Rolson, R. K.; Perry, G.; Smith, M. A. Nanoparticle iron chelators: A new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance Neurosci. Lett. 2006, 406, 189-193
-
(2006)
Neurosci. Lett.
, vol.406
, pp. 189-193
-
-
Liu, G.1
Men, P.2
Harris, P.L.R.3
Rolson, R.K.4
Perry, G.5
Smith, M.A.6
-
35
-
-
84889237760
-
Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: In vitro and in vivo studies
-
Kamalinia, G.; Khodagholi, F.; Atyabi, F.; Amini, M.; Shaerzadeh, F.; Sharifzadeh, M.; Dinarvand, R. Enhanced brain delivery of deferasirox-lactoferrin conjugates for iron chelation therapy in neurodegenerative disorders: In vitro and in vivo studies Mol. Pharmaceutics 2013, 10, 4418-4431
-
(2013)
Mol. Pharmaceutics
, vol.10
, pp. 4418-4431
-
-
Kamalinia, G.1
Khodagholi, F.2
Atyabi, F.3
Amini, M.4
Shaerzadeh, F.5
Sharifzadeh, M.6
Dinarvand, R.7
-
36
-
-
34147157711
-
Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting β-amyloid burden
-
Malm, T. M.; Iivonen, H.; Goldsteins, G.; Keksa-Goldsteine, V.; Ahtoniemi, T.; Kanninen, K.; Salminen, A.; Auriola, S.; VanGroen, T.; Tanila, H.; Koistinaho, J. Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting β-amyloid burden J. Neurosci. 2007, 27, 3712-3721
-
(2007)
J. Neurosci.
, vol.27
, pp. 3712-3721
-
-
Malm, T.M.1
Iivonen, H.2
Goldsteins, G.3
Keksa-Goldsteine, V.4
Ahtoniemi, T.5
Kanninen, K.6
Salminen, A.7
Auriola, S.8
Vangroen, T.9
Tanila, H.10
Koistinaho, J.11
-
37
-
-
78650669293
-
Design of small molecules that target metal-Aβ species and regulate metal induced Aβ-aggregation and neurotoxicity
-
Choi, J.-S.; Braymer, J. J.; Nanga, R. P. R.; Ramamoorthy, A.; Lim, M. H. Design of small molecules that target metal-Aβ species and regulate metal induced Aβ-aggregation and neurotoxicity Proc. Natl. Acad. Sci. U.S.A. 2011, 107, 21990-21995
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 21990-21995
-
-
Choi, J.-S.1
Braymer, J.J.2
Nanga, R.P.R.3
Ramamoorthy, A.4
Lim, M.H.5
-
38
-
-
84923167087
-
A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimers disease
-
Beck, M. W.; Oh, S. B.; Kerr, R. A.; Lee, H. J.; Kim, S. H.; Kim, S.; Jang, M.; Ruotolo, B. T.; Lee, J.-Y.; Lim, M. H. A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimers disease Chem. Sci. 2015, 6, 1879-1886
-
(2015)
Chem. Sci.
, vol.6
, pp. 1879-1886
-
-
Beck, M.W.1
Oh, S.B.2
Kerr, R.A.3
Lee, H.J.4
Kim, S.H.5
Kim, S.6
Jang, M.7
Ruotolo, B.T.8
Lee, J.-Y.9
Lim, M.H.10
-
39
-
-
76749107569
-
Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimers disease
-
Lakatos, A.; Zsigó, é.; Hollender, D.; Nagy, N. V.; Fülöp, L.; Simon, D.; Bozsó, L.; Kiss, T. Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimers disease Dalton Trans. 2010, 39, 1302-1315
-
(2010)
Dalton Trans.
, vol.39
, pp. 1302-1315
-
-
Lakatos, A.1
Zsigó, E.2
Hollender, D.3
Nagy, N.V.4
Fülöp, L.5
Simon, D.6
Bozsó, L.7
Kiss, T.8
-
40
-
-
34347237264
-
Synthesis, characterization, and metal coordination ability of multifunctional carbohydrate-containing compounds for Alzheimers therapy
-
Storr, T.; Merkel, M.; Song-Zhao, G. X.; Scott, L. E.; Green, D. E.; Bowen, M. L.; Thompson, K. H.; Patrick, B. O.; Schugar, H. J.; Orvig, C. Synthesis, characterization, and metal coordination ability of multifunctional carbohydrate-containing compounds for Alzheimers therapy J. Am. Chem. Soc. 2007, 129, 7453-7463
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 7453-7463
-
-
Storr, T.1
Merkel, M.2
Song-Zhao, G.X.3
Scott, L.E.4
Green, D.E.5
Bowen, M.L.6
Thompson, K.H.7
Patrick, B.O.8
Schugar, H.J.9
Orvig, C.10
-
41
-
-
84869088045
-
A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)-induced Aβ aggregation
-
Noël, S.; Perez, F.; Pedersen, J. T.; Aliès, B.; Ladeira, S.; Sayen, S.; Guillon, E.; Gras, E.; Hureau, C. A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)-induced Aβ aggregation J. Inorg. Biochem. 2012, 117, 322-325
-
(2012)
J. Inorg. Biochem.
, vol.117
, pp. 322-325
-
-
Noël, S.1
Perez, F.2
Pedersen, J.T.3
Aliès, B.4
Ladeira, S.5
Sayen, S.6
Guillon, E.7
Gras, E.8
Hureau, C.9
-
42
-
-
84903602563
-
Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants
-
Noël, S.; Bustos Rodriguez, S.; Sayen, S.; Guillon, E.; Faller, P.; Hureau, C. Use of a new water-soluble Zn sensor to determine Zn affinity for the amyloid-β peptide and relevant mutants Metallomics 2014, 6, 1220-1222
-
(2014)
Metallomics
, vol.6
, pp. 1220-1222
-
-
Noël, S.1
Bustos Rodriguez, S.2
Sayen, S.3
Guillon, E.4
Faller, P.5
Hureau, C.6
-
43
-
-
84885461983
-
Neuroprotective role of a novel copper chelator against Aβ42 induced neurotoxicity
-
Singh, S. K.; Sinha, P.; Mishra, L.; Srikrishna, S. Neuroprotective role of a novel copper chelator against Aβ42 induced neurotoxicity Int. J. Alzheimers Dis. 2013, 567128
-
(2013)
Int. J. Alzheimers Dis.
, pp. 567128
-
-
Singh, S.K.1
Sinha, P.2
Mishra, L.3
Srikrishna, S.4
-
44
-
-
41949115990
-
Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide
-
Donnelly, P. S.; Caragounis, A.; Du, T.; Laughton, K. M.; Volitakis, I.; Cherny, R. A.; Sharples, R. A.; Hill, A. F.; Li, Q.-X.; Masters, C. L.; Barnham, K. J.; White, A. R. Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptide J. Biol. Chem. 2008, 283, 4568-4577
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 4568-4577
-
-
Donnelly, P.S.1
Caragounis, A.2
Du, T.3
Laughton, K.M.4
Volitakis, I.5
Cherny, R.A.6
Sharples, R.A.7
Hill, A.F.8
Li, Q.-X.9
Masters, C.L.10
Barnham, K.J.11
White, A.R.12
-
45
-
-
77950817555
-
A prochelator activated by β-secretase inhibits Aβ aggregation and suppresses copper-induced reactive oxygen species formation
-
Folk, D. S.; Franz, K. J. A prochelator activated by β-secretase inhibits Aβ aggregation and suppresses copper-induced reactive oxygen species formation J. Am. Chem. Soc. 2010, 132, 4994-4995
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 4994-4995
-
-
Folk, D.S.1
Franz, K.J.2
-
46
-
-
84867757387
-
The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation
-
references therein
-
Amijee, H.; Bate, C.; Williams, A.; Virdee, J.; Jeggo, R.; Spanswick, D.; Scopes, D. I. C.; Treherne, J. M.; Mazzitelli, S.; Chawner, R.; Eyers, C. E.; Doig, A. J. The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation Biochemistry 2012, 51, 8338-8352 and references therein.
-
(2012)
Biochemistry
, vol.51
, pp. 8338-8352
-
-
Amijee, H.1
Bate, C.2
Williams, A.3
Virdee, J.4
Jeggo, R.5
Spanswick, D.6
Scopes, D.I.C.7
Treherne, J.M.8
Mazzitelli, S.9
Chawner, R.10
Eyers, C.E.11
Doig, A.J.12
-
47
-
-
84868542498
-
Liberation of copper from amyloid plaques: Making a risk factor useful for Alzheimers disease treatment
-
Geng, J.; Li, M.; Wu, L.; Ren, J.; Qu, X. Liberation of copper from amyloid plaques: Making a risk factor useful for Alzheimers disease treatment J. Med. Chem. 2012, 55, 9146-9155
-
(2012)
J. Med. Chem.
, vol.55
, pp. 9146-9155
-
-
Geng, J.1
Li, M.2
Wu, L.3
Ren, J.4
Qu, X.5
-
48
-
-
84867386502
-
Multitarget-directed benzylideneindanone derivatives: Anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO B) inhibition properties against Alzheimers disease
-
Huang, L.; Lu, C.; Sun, Y.; Mao, F.; Luo, Z.; Su, T.; Jiang, H.; Shan, W.; Li, X. Multitarget-directed benzylideneindanone derivatives: Anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO B) inhibition properties against Alzheimers disease J. Med. Chem. 2012, 55, 8483-8492
-
(2012)
J. Med. Chem.
, vol.55
, pp. 8483-8492
-
-
Huang, L.1
Lu, C.2
Sun, Y.3
Mao, F.4
Luo, Z.5
Su, T.6
Jiang, H.7
Shan, W.8
Li, X.9
-
49
-
-
84885962163
-
Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs Ladostigil and M30 derived from Rasigiline
-
Youdim, B. H. M. Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs Ladostigil and M30 derived from Rasigiline Exp. Neurobiol. 2013, 22, 1-10
-
(2013)
Exp. Neurobiol.
, vol.22
, pp. 1-10
-
-
Youdim, B.H.M.1
-
50
-
-
78649453067
-
Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities
-
Zheng, H.; Youdim, M. B. H.; Fridkin, M. Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities ACS Chem. Neurosci. 2010, 1, 737-746
-
(2010)
ACS Chem. Neurosci.
, vol.1
, pp. 737-746
-
-
Zheng, H.1
Youdim, M.B.H.2
Fridkin, M.3
-
51
-
-
84891877160
-
Design, synthesis and evaluation of novel tacrine-rhein hybrids as functional agents for the treatment of Alzheimers disease
-
Li, S.-Y.; Jiang, N.; Xie, S.-S.; Wang, K. D. G.; Wang, X.-B.; Kong, L.-Y. Design, synthesis and evaluation of novel tacrine-rhein hybrids as functional agents for the treatment of Alzheimers disease Org. Biomol. Chem. 2014, 12, 801-814p
-
(2014)
Org. Biomol. Chem.
, vol.12
, pp. 801-814p
-
-
Li, S.-Y.1
Jiang, N.2
Xie, S.-S.3
Wang, K.D.G.4
Wang, X.-B.5
Kong, L.-Y.6
-
52
-
-
77955423401
-
Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimers disease
-
Huang, W.; Lv, D.; Yu, H.; Shen, R.; Kim, S. C.; Wu, P.; Luo, K.; Li, J.; Hu, Y. Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimers disease Bioorg. Med. Chem. 2010, 18, 5610-5615
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 5610-5615
-
-
Huang, W.1
Lv, D.2
Yu, H.3
Shen, R.4
Kim, S.C.5
Wu, P.6
Luo, K.7
Li, J.8
Hu, Y.9
-
53
-
-
84908015055
-
Design, synthesis, and evaluation of multitarget directed selenium-containing clioquinol derivatives for the treatment of Alzheimers disease
-
Wang, Z.; Wang, Y.; Li, W.; Mao, F.; Sun, Y.; Huang, L.; Li, X. Design, synthesis, and evaluation of multitarget directed selenium-containing clioquinol derivatives for the treatment of Alzheimers disease ACS Chem. Neurosci. 2014, 5, 952-962
-
(2014)
ACS Chem. Neurosci.
, vol.5
, pp. 952-962
-
-
Wang, Z.1
Wang, Y.2
Li, W.3
Mao, F.4
Sun, Y.5
Huang, L.6
Li, X.7
-
54
-
-
0021360660
-
Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptans
-
Chaudiere, J.; Wilhelmsen, E. C.; Tappel, A. L. Mechanism of selenium-glutathione peroxidase and its inhibition by mercaptocarboxylic acids and other mercaptans J. Biol. Chem. 1984, 259, 1043-1050
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 1043-1050
-
-
Chaudiere, J.1
Wilhelmsen, E.C.2
Tappel, A.L.3
-
55
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimers disease transgenic mice
-
Cherny, R. A.; Atwood, C. S.; Xilinas, M. E.; Gray, D. N.; Jones, W. D.; McLean, C. A.; Barnham, K. J.; Volitakis, I.; Fraser, F. W.; Kim, Y.-S.; Huang, X.; Goldstein, L. E.; Moir, R. D.; Lim, J. T.; Beyreuther, K.; Zheng, H.; Tanzi, R. E.; Masters, C. L.; Bush, A. I. Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimers disease transgenic mice Neuron 2001, 30, 665-676
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.-S.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
56
-
-
78149282621
-
Impairment of recognition memory and hippocampal long term potentiation after acute exposure to chloroquinol
-
Takeda, A.; Takada, S.; Ando, M.; Itagaki, K.; Tamano, H.; Suzuki, M.; Iwaki, H.; Oku, N. Impairment of recognition memory and hippocampal long term potentiation after acute exposure to chloroquinol Neuroscience 2010, 171, 443-450
-
(2010)
Neuroscience
, vol.171
, pp. 443-450
-
-
Takeda, A.1
Takada, S.2
Ando, M.3
Itagaki, K.4
Tamano, H.5
Suzuki, M.6
Iwaki, H.7
Oku, N.8
-
57
-
-
84929587594
-
-
http://www.drugbank.ca/drugs/db04815.
-
-
-
-
58
-
-
0031761894
-
Clioquinol-zinc chelate: A candidate causative agent of subacute myelo-optic neuropathy
-
Arbiser, J. L.; Kraeft, S.-K.; van Leeuwen, R.; Hurwitz, S. J.; Selig, M.; Dickersin, G. R.; Flint, A.; Byers, H. R.; Chen, L. B. Clioquinol-zinc chelate: A candidate causative agent of subacute myelo-optic neuropathy Mol. Med. 1998, 4, 665-670
-
(1998)
Mol. Med.
, vol.4
, pp. 665-670
-
-
Arbiser, J.L.1
Kraeft, S.-K.2
Van Leeuwen, R.3
Hurwitz, S.J.4
Selig, M.5
Dickersin, G.R.6
Flint, A.7
Byers, H.R.8
Chen, L.B.9
-
59
-
-
66249101637
-
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+
-
Andersson, D. A.; Gentry, C.; Moss, S.; Bevan, S. Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+ Proc. Natl. Acad. Sci. U.S.A. 2009, 109, 8374-8379
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 8374-8379
-
-
Andersson, D.A.1
Gentry, C.2
Moss, S.3
Bevan, S.4
-
60
-
-
33947465547
-
The reactions of 8-quinolinol
-
Phillips, J. P. The reactions of 8-quinolinol Chem. Rev. 1956, 56, 271-297
-
(1956)
Chem. Rev.
, vol.56
, pp. 271-297
-
-
Phillips, J.P.1
-
61
-
-
34249786569
-
Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; Implications for Alzheimers and Huntingtons disease therapy
-
Ferrada, E.; Arancibia, V.; Loeb, B.; Norambuena, E.; Olea-Azar, C.; Huidobro-Toro, J. P. Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimers and Huntingtons disease therapy Neurotoxicology 2007, 28, 445-449
-
(2007)
Neurotoxicology
, vol.28
, pp. 445-449
-
-
Ferrada, E.1
Arancibia, V.2
Loeb, B.3
Norambuena, E.4
Olea-Azar, C.5
Huidobro-Toro, J.P.6
-
62
-
-
77954344206
-
PBT2 rapidly improves cognition in Alzheimers disease: Additional phase II analyses
-
Faux, N. G.; Ritchie, C. W.; Gunn, A.; Rembach, A.; Tsatsanis, A.; Bedo, J.; Harrison, J.; Lannfelt, L.; Blennow, K.; Zetterberg, H.; Ingelsson, M.; Masters, C. L.; Tanzi, R. E.; Cummings, J. L.; Herd, C. M.; Bush, A. I. PBT2 rapidly improves cognition in Alzheimers disease: additional phase II analyses J. Alzheimers Dis. 2010, 20, 509-516
-
(2010)
J. Alzheimers Dis.
, vol.20
, pp. 509-516
-
-
Faux, N.G.1
Ritchie, C.W.2
Gunn, A.3
Rembach, A.4
Tsatsanis, A.5
Bedo, J.6
Harrison, J.7
Lannfelt, L.8
Blennow, K.9
Zetterberg, H.10
Ingelsson, M.11
Masters, C.L.12
Tanzi, R.E.13
Cummings, J.L.14
Herd, C.M.15
Bush, A.I.16
-
63
-
-
84929587595
-
-
http://www.prnewswire.com/news-releases/prana-biotechnology-announces-preliminary-results-of-phase-2-imagine-trial-of-pbt2-in-alzheimers-disease-253173581.html.
-
-
-
-
64
-
-
84918785958
-
Safety, tolerability, and efficacy of PBT2 in Huntingtons disease: A phase 2, randomised, double-blind, placebo-controlled trial
-
Huntington Study Group Reach2HD Investigators
-
Huntington Study Group Reach2HD Investigators Safety, tolerability, and efficacy of PBT2 in Huntingtons disease: A phase 2, randomised, double-blind, placebo-controlled trial Lancet Neurol. 2015, 14, 39-47
-
(2015)
Lancet Neurol.
, vol.14
, pp. 39-47
-
-
-
65
-
-
84877779844
-
Cerium oxide caged metal chelator: Anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimers disease treatment
-
Li, M.; Shi, P.; Xu, C.; Ren, J.; Qu, X. Cerium oxide caged metal chelator: Anti-aggregation and anti-oxidation integrated H2O2-responsive controlled drug release for potential Alzheimers disease treatment Chem. Sci. 2013, 4, 2536-2542
-
(2013)
Chem. Sci.
, vol.4
, pp. 2536-2542
-
-
Li, M.1
Shi, P.2
Xu, C.3
Ren, J.4
Qu, X.5
-
66
-
-
39249084071
-
Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells
-
Park, E.-J.; Choi, J.; Park, Y.-K.; Park, K. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells Toxicology 2008, 245, 90-100
-
(2008)
Toxicology
, vol.245
, pp. 90-100
-
-
Park, E.-J.1
Choi, J.2
Park, Y.-K.3
Park, K.4
-
67
-
-
84887846339
-
Gold nanocage-based dual responsive "caged metal chelator" release system: Noninvasive remote control with near infrared for potential treatment of Alzheimers disease
-
Shi, P.; Li, M.; Ren, J.; Qu, X. Gold nanocage-based dual responsive "caged metal chelator" release system: Noninvasive remote control with near infrared for potential treatment of Alzheimers disease Adv. Funct. Mater. 2013, 23, 5412-5419
-
(2013)
Adv. Funct. Mater.
, vol.23
, pp. 5412-5419
-
-
Shi, P.1
Li, M.2
Ren, J.3
Qu, X.4
-
68
-
-
84904015628
-
Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation
-
Oliveri, V.; Attanasio, F.; Puglisi, A.; Spencer, J.; Sgarlata, C.; Vecchio, G. Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation Chem.-Eur. J. 2014, 20, 8954-8964
-
(2014)
Chem.-Eur. J.
, vol.20
, pp. 8954-8964
-
-
Oliveri, V.1
Attanasio, F.2
Puglisi, A.3
Spencer, J.4
Sgarlata, C.5
Vecchio, G.6
-
69
-
-
2942750367
-
Clioquinol, a drug for Alzheimers disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes
-
Di Vaira, M.; Bazzicalupi, C.; Orioli, P.; Messori, L.; Bruni, B.; Zatta, P. Clioquinol, a drug for Alzheimers disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes Inorg. Chem. 2004, 43, 3795-3797
-
(2004)
Inorg. Chem.
, vol.43
, pp. 3795-3797
-
-
Di Vaira, M.1
Bazzicalupi, C.2
Orioli, P.3
Messori, L.4
Bruni, B.5
Zatta, P.6
-
70
-
-
84896508103
-
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity
-
Matlack, K. E. S.; Tardiff, D. F.; Narayan, P.; Hamamichi, S.; Caldwell, K. A.; Caldwell, G. A.; Lindquist, S. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 4013-4018
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 4013-4018
-
-
Matlack, K.E.S.1
Tardiff, D.F.2
Narayan, P.3
Hamamichi, S.4
Caldwell, K.A.5
Caldwell, G.A.6
Lindquist, S.7
-
71
-
-
10644280708
-
Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimers disease
-
Treiber, C.; Simons, A.; Strauss, M.; Hafner, M.; Cappai, R.; Bayer, T. A.; Multhaup, G. Clioquinol mediates copper uptake and counteracts copper efflux activities of the amyloid precursor protein of Alzheimers disease J. Biol. Chem. 2004, 50, 51958-51964
-
(2004)
J. Biol. Chem.
, vol.50
, pp. 51958-51964
-
-
Treiber, C.1
Simons, A.2
Strauss, M.3
Hafner, M.4
Cappai, R.5
Bayer, T.A.6
Multhaup, G.7
-
72
-
-
46149107512
-
Rapid restoration of cognition in Alzheimers transgenic mice with 8-hydroxyquinoline analogs is associated with decreased interstitial Abeta
-
Adlard, P. A.; Cherny, R. A.; Finkelstein, D. I.; Gautier, E.; Robb, E.; Cortes, M.; Volitakis, I.; Liu, X.; Smith, J. P.; Perez, K.; Laughton, K.; Li, Q. X.; Charman, S. A.; Nicolazzo, J. A.; Wilkins, S.; Delava, K.; Lynch, T.; Kok, G.; Richtie, C. W.; Tanzi, R. E.; Cappai, R.; Masters, C. L.; Barnham, K. J.; Bush, A. I. Rapid restoration of cognition in Alzheimers transgenic mice with 8-hydroxyquinoline analogs is associated with decreased interstitial Abeta Neuron 2008, 59, 43-55
-
(2008)
Neuron
, vol.59
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
Gautier, E.4
Robb, E.5
Cortes, M.6
Volitakis, I.7
Liu, X.8
Smith, J.P.9
Perez, K.10
Laughton, K.11
Li, Q.X.12
Charman, S.A.13
Nicolazzo, J.A.14
Wilkins, S.15
Delava, K.16
Lynch, T.17
Kok, G.18
Richtie, C.W.19
Tanzi, R.E.20
Cappai, R.21
Masters, C.L.22
Barnham, K.J.23
Bush, A.I.24
more..
-
73
-
-
84923293193
-
The necessity of having a tetradentate ligand to extract copper(II) ion from amyloid
-
Nguyen, M.; Rechignat, L.; Robert, A.; Meunier, B. The necessity of having a tetradentate ligand to extract copper(II) ion from amyloid ChemistryOpen 2015, 4, 27-31
-
(2015)
ChemistryOpen
, vol.4
, pp. 27-31
-
-
Nguyen, M.1
Rechignat, L.2
Robert, A.3
Meunier, B.4
-
74
-
-
84876179956
-
Mixed ligands Cu2+ complexes of a model therapeutic with Alzheimers amyloid-β peptide and monoamine neurotransmitters
-
Kenche, V. B.; Zawisza, I.; Masters, C. L.; Bal, W.; Barnham, K. J.; Drew, S. C. Mixed ligands Cu2+ complexes of a model therapeutic with Alzheimers amyloid-β peptide and monoamine neurotransmitters Inorg. Chem. 2012, 52, 4303-4318
-
(2012)
Inorg. Chem.
, vol.52
, pp. 4303-4318
-
-
Kenche, V.B.1
Zawisza, I.2
Masters, C.L.3
Bal, W.4
Barnham, K.J.5
Drew, S.C.6
-
75
-
-
38149012085
-
Preparation and study of new poly-8-hydroxyquinoline chelators for an anti-Alzheimer strategy
-
Deraeve, C.; Boldron, C.; Maraval, A.; Mazarguil, H.; Gornitzka, H.; Vendier, L.; Pitié, M.; Meunier, B. Preparation and study of new poly-8-hydroxyquinoline chelators for an anti-Alzheimer strategy Chem.-Eur. J. 2008, 14, 682-696
-
(2008)
Chem.-Eur. J.
, vol.14
, pp. 682-696
-
-
Deraeve, C.1
Boldron, C.2
Maraval, A.3
Mazarguil, H.4
Gornitzka, H.5
Vendier, L.6
Pitié, M.7
Meunier, B.8
-
76
-
-
33846871883
-
Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents
-
Deraeve, C.; Pitié, M.; Mazarguil, H.; Meunier, B. Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents New J. Chem. 2007, 31, 193-195
-
(2007)
New J. Chem.
, vol.31
, pp. 193-195
-
-
Deraeve, C.1
Pitié, M.2
Mazarguil, H.3
Meunier, B.4
-
77
-
-
57749094109
-
Preparation of new bis(8-aminoquinoline) ligands and comparison with bis(8-hydroxyquinoline) ligands on their ability to chelate CuII and ZnII
-
Deraeve, C.; Maraval, A.; Vendier, L.; Faugeroux, V.; Pitié, M.; Meunier, B. Preparation of new bis(8-aminoquinoline) ligands and comparison with bis(8-hydroxyquinoline) ligands on their ability to chelate CuII and ZnII Eur. J. Inorg. Chem. 2008, 5622-5631
-
(2008)
Eur. J. Inorg. Chem.
, pp. 5622-5631
-
-
Deraeve, C.1
Maraval, A.2
Vendier, L.3
Faugeroux, V.4
Pitié, M.5
Meunier, B.6
-
78
-
-
84901380993
-
Characterization of new specific copper chelators as potential drugs for Alzheimers disease treatment
-
Nguyen, M.; Robert, A.; Sournia-Saquet, A.; Vendier, L.; Meunier, B. Characterization of new specific copper chelators as potential drugs for Alzheimers disease treatment Chem.-Eur. J. 2014, 20, 6771-6785
-
(2014)
Chem.-Eur. J.
, vol.20
, pp. 6771-6785
-
-
Nguyen, M.1
Robert, A.2
Sournia-Saquet, A.3
Vendier, L.4
Meunier, B.5
-
79
-
-
84865189086
-
Copper chelator induced efficient episodic memory recovery in a non-transgenic alzheimers mouse model
-
Ceccom, J.; Coslédan, F.; Halley, H.; Francès, B.; Lassalle, J.-M.; Meunier, B. Copper chelator induced efficient episodic memory recovery in a non-transgenic alzheimers mouse model PLosOne 2012, 7 e43105
-
(2012)
PLosOne
, vol.7
, pp. 43105
-
-
Ceccom, J.1
Coslédan, F.2
Halley, H.3
Francès, B.4
Lassalle, J.-M.5
Meunier, B.6
|