Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: Structure-activity investigation of metalloenzyme inhibition by iron chelators

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 631-639

  Liu, Zu D ^a   Kayyali, Reem ^a   Hider, Robert C ^a   Porter, John B ^b   Theobald, Anthony E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 PYRIDONE DERIVATIVE; DEFERIPRONE; DEFEROXAMINE; IRON CHELATING AGENT;

ARTICLE; BETA THALASSEMIA; BIOAVAILABILITY; BLOOD TRANSFUSION; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROPHOBICITY; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ENZYME INHIBITORS; IRON; IRON CHELATING AGENTS; MALE; PYRIDINES; PYRIDONES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037203975     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010817i     Document Type: Article

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