A new water-soluble Cu(II) chelator that retrieves Cu from Cu(amyloid-β) species, stops associated ROS production and prevents Cu(II)-induced Aβ aggregation

Journal of Inorganic Biochemistry

Volumn 117, Issue , 2012, Pages 322-325

  Noël, Sabrina ^a,b   Perez, Fabien ^a,b   Pedersen, Jeppe T ^c   Alies, Bruno ^a,b   Ladeira, Sonia ^a,b   Sayen, Stéphanie ^d   Guillon, Emmanuel ^d   Gras, Emmanuel ^a,b   Hureau, Christelle ^a,b  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

Aggregation; Alzheimer; Chelator; Copper; Peptide; ROS

Indexed keywords

AMYLOID BETA PROTEIN; CHELATING AGENT; COPPER; COPPER COMPLEX; CUPRIC ION; DIAMINE DERIVATIVE; IRON; LIGAND; METAL ION; N,N' BIS[( 5 SULFONATO 2 HYDROXY)BENZYL] N,N' DIMETHYLETHANE 1,2 DIAMINE; REACTIVE OXYGEN METABOLITE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; WATER;

BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG SOLUBILITY; ELECTRON SPIN RESONANCE; IN VITRO STUDY; OXIDATION REDUCTION STATE; PH; PHYSICAL CHEMISTRY; POTENTIOMETRY; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN SYNTHESIS; ULTRAVIOLET SPECTROSCOPY; ULTRAVIOLET VISIBLE SPECTROMETRY; X RAY DIFFRACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BENZENESULFONATES; CHELATING AGENTS; COPPER; ETHYLENEDIAMINES; HYDROGEN-ION CONCENTRATION; OXIDATIVE STRESS; OXYGEN; REACTIVE OXYGEN SPECIES; SOLUBILITY; WATER;

EID: 84869088045     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2012.05.016     Document Type: Conference Paper

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