Multitarget-directed benzylideneindanone derivatives: Anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8483-8492

  Huang, Ling ^a   Lu, Chuanjun ^a   Sun, Yang ^a   Mao, Fei ^a   Luo, Zonghua ^a   Su, Tao ^a   Jiang, Huailei ^a   Shan, Wenjun ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4 DIMETHOXYBENZYLIDENE) 5,6 DIMETHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 2 (3,4 DIMETHOXYBENZYLIDENE) 6 HYDROXY 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 2 [4 (DIMETHYLAMINO)BENZYLIDENE) 6 HYDROXY 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 2 [4 (DIMETHYLAMINO)BENZYLIDENE] 5,6 DIMETHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 5,6 DIHYDROXY 2 [4 [METHYL(PROPYL)AMINO]BENZYLIDENE] 2,3 DIHYDRO 1H INDEN 1 ONE 4 METHYLBENZENESULFONATE; 6 HYDROXY 2 (3 HYDROXY 4 METHOXYBENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 HYDROXY 2 (4 HYDROXY 3 METHOXYBENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 ONE; 6 HYDROXY 2 (4 HYDROXYBENZYLIDENE) 5 METHOXY 2,3 DIHYDRO 1H INDEN 1 OND; 6 HYDROXY 5 METHOXY 2 (4 METHOXYBENZYLIDENE) 2,3 DIHYDRO 1H INDEN 1 ONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; BENZYLIDENEINDANONE DERIVATIVE; CHELATING AGENT; CLORGYLINE; CURCUMIN; INDANONE DERIVATIVE; LADOSTIGIL; MONOAMINE OXIDASE B INHIBITOR; RASAGILINE; SELEGILINE; TROLOX C; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CHELATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IN VITRO STUDY; METAL BINDING; MOLECULAR DOCKING; PROTEIN AGGREGATION; STOICHIOMETRY; TRANSMISSION ELECTRON MICROSCOPY;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; BENZYLIDENE COMPOUNDS; CATIONS, DIVALENT; CHELATING AGENTS; COPPER; HUMANS; INDANS; IRON; ISOENZYMES; MOLECULAR DOCKING SIMULATION; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC;

EID: 84867386502     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300978h     Document Type: Article

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