The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation

Biochemistry

Volumn 51, Issue 42, 2012, Pages 8338-8352

  Amijee, Hozefa ^a,b   Bate, Clive ^c   Williams, Alun ^c   Virdee, Jasmeet ^d   Jeggo, Ross ^d   Spanswick, David ^d   Scopes, David I C ^a   Treherne, J Mark ^a   Mazzitelli, Sonia ^b   Chawner, Ross ^b   Eyers, Claire E ^b   Doig, Andrew J ^b  

^a Senexis Limited   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c ROYAL VETERINARY COLLEGE   (United Kingdom)

^d NEUROSOLUTIONS LTD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; BRAIN SLICES; DOSE-RESPONSE CURVES; ION MOBILITY-MASS SPECTROMETRY; LACTATE DEHYDROGENASE; LONG-TERM POTENTIATIONS; NEURONAL CELL; OPTIMISATIONS; PEPTIDE INHIBITORS; SDS-PAGE; SHEET FORMATION; SYNAPTOPHYSIN; THIOFLAVIN; THIOFLAVIN T; TOXICITY ASSAYS; TRAVELING WAVE;

CELL CULTURE; CELL DEATH; ELECTRON MICROSCOPY; GLYCOPROTEINS; LEAD COMPOUNDS; OLIGOMERS; PEPTIDES; STRUCTURAL OPTIMIZATION;

TOXICITY;

AMYLOID BETA PROTEIN[1-42]; LACTATE DEHYDROGENASE; NOOTROPIC AGENT; OLIGOMER; PEPTIDE; SEN 304; SYNAPTOPHYSIN; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA SHEET; BRAIN SLICE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG PROTEIN BINDING; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; HIPPOCAMPUS; HUMAN; HUMAN CELL; LONG TERM POTENTIATION; MALE; MASS SPECTROMETRY; MOUSE; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN METHYLATION; RAT; SURFACE PLASMON RESONANCE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; CIRCULAR DICHROISM; HUMANS; LONG-TERM POTENTIATION; MALE; MICE; NEURONS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; RATS; SURFACE PLASMON RESONANCE; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 84867757387     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300415v     Document Type: Article

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