-
1
-
-
58849158450
-
Pharmacotherapeutic targets in Alzheimer's disease
-
Biran, Y., Masters, C. L., Barnham, K. J., Bush, A. I., and Adlard, P. A. (2009) Pharmacotherapeutic targets in Alzheimer's disease J. Cell. Mol. Med. 13, 61-86
-
(2009)
J. Cell. Mol. Med.
, vol.13
, pp. 61-86
-
-
Biran, Y.1
Masters, C.L.2
Barnham, K.J.3
Bush, A.I.4
Adlard, P.A.5
-
2
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., and Markesbery, W. R. (1998) Copper, iron and zinc in Alzheimer's disease senile plaques J. Neurol. Sci. 158, 47-52
-
(1998)
J. Neurol. Sci.
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
3
-
-
0030885482
-
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
-
Smith, M. A., Harris, P. L., Sayre, L. M., and Perry, G. (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals Proc. Natl. Acad. Sci. U.S.A. 94, 9866-9868
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 9866-9868
-
-
Smith, M.A.1
Harris, P.L.2
Sayre, L.M.3
Perry, G.4
-
4
-
-
75149152568
-
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment
-
Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Jr., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., Nakamura, M., Nunomura, A., and Perry, G. (2010) Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment J. Alzheimers Dis. 19, 363-372
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 363-372
-
-
Smith, M.A.1
Zhu, X.2
Tabaton, M.3
Liu, G.4
Mckeel Jr., D.W.5
Cohen, M.L.6
Wang, X.7
Siedlak, S.L.8
Dwyer, B.E.9
Hayashi, T.10
Nakamura, M.11
Nunomura, A.12
Perry, G.13
-
5
-
-
34248577510
-
Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5′untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator
-
Bandyopadhyay, S., Huang, X., Cho, H., Greig, N. H., Youdim, M. B., and Rogers, J. T. (2006) Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5′untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator J. Neural Transm. Suppl. 237-247
-
(2006)
J. Neural Transm. Suppl.
, pp. 237-247
-
-
Bandyopadhyay, S.1
Huang, X.2
Cho, H.3
Greig, N.H.4
Youdim, M.B.5
Rogers, J.T.6
-
6
-
-
0347928847
-
An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript
-
Rogers, J. T., Randall, J. D., Cahill, C. M., Eder, P. S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S. S., Utsuki, T., Greig, N. H., Lahiri, D. K., Tanzi, R. E., Bush, A. I., Giordano, T., and Gullans, S. R. (2002) An iron-responsive element type II in the 5′-untranslated region of the Alzheimer's amyloid precursor protein transcript J. Biol. Chem. 277, 45518-45528
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45518-45528
-
-
Rogers, J.T.1
Randall, J.D.2
Cahill, C.M.3
Eder, P.S.4
Huang, X.5
Gunshin, H.6
Leiter, L.7
McPhee, J.8
Sarang, S.S.9
Utsuki, T.10
Greig, N.H.11
Lahiri, D.K.12
Tanzi, R.E.13
Bush, A.I.14
Giordano, T.15
Gullans, S.R.16
-
7
-
-
43049150678
-
Metals in Alzheimer's and Parkinson's diseases
-
Barnham, K. J. and Bush, A. I. (2008) Metals in Alzheimer's and Parkinson's diseases Curr. Opin. Chem. Biol. 12, 222-228
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 222-228
-
-
Barnham, K.J.1
Bush, A.I.2
-
8
-
-
38949167692
-
Oxidative stress and neurotoxicity
-
Sayre, L. M., Perry, G., and Smith, M. A. (2008) Oxidative stress and neurotoxicity Chem. Res. Toxicol. 21, 172-188
-
(2008)
Chem. Res. Toxicol.
, vol.21
, pp. 172-188
-
-
Sayre, L.M.1
Perry, G.2
Smith, M.A.3
-
9
-
-
36749095848
-
Therapeutic treatment of Alzheimer's disease using metal complexing agents
-
Price, K. A., Crouch, P. J., and White, A. R. (2007) Therapeutic treatment of Alzheimer's disease using metal complexing agents Recent Pat. CNS Drug Discovery 2, 180-187
-
(2007)
Recent Pat. CNS Drug Discovery
, vol.2
, pp. 180-187
-
-
Price, K.A.1
Crouch, P.J.2
White, A.R.3
-
10
-
-
70350686620
-
Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease
-
Scott, L. E. and Orvig, C. (2009) Medicinal inorganic chemistry approaches to passivation and removal of aberrant metal ions in disease Chem. Rev. 109, 4885-4910
-
(2009)
Chem. Rev.
, vol.109
, pp. 4885-4910
-
-
Scott, L.E.1
Orvig, C.2
-
11
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., MacGregor, L., Kiers, L., Cherny, R., Li, Q. X., Tammer, A., Carrington, D., Mavros, C., Volitakis, I., Xilinas, M., Ames, D., Davis, S., Beyreuther, K., Tanzi, R. E., and Masters, C. L. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Arch. Neurol. 60, 1685-1691
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
MacKinnon, A.3
MacFarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
12
-
-
0026361443
-
Clinically useful chelators of tripositive elements
-
Hider, R. C. and Hall, A. D. (1991) Clinically useful chelators of tripositive elements Prog. Med. Chem. 28, 41-173
-
(1991)
Prog. Med. Chem.
, vol.28
, pp. 41-173
-
-
Hider, R.C.1
Hall, A.D.2
-
13
-
-
0035865905
-
Redox-active iron mediates amyloid-beta toxicity
-
Rottkamp, C. A., Raina, A. K., Zhu, X., Gaier, E., Bush, A. I., Atwood, C. S., Chevion, M., Perry, G., and Smith, M. A. (2001) Redox-active iron mediates amyloid-beta toxicity Free Radical Biol. Med. 30, 447-450
-
(2001)
Free Radical Biol. Med.
, vol.30
, pp. 447-450
-
-
Rottkamp, C.A.1
Raina, A.K.2
Zhu, X.3
Gaier, E.4
Bush, A.I.5
Atwood, C.S.6
Chevion, M.7
Perry, G.8
Smith, M.A.9
-
14
-
-
0033964859
-
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: A central role for bound transition metals
-
Sayre, L. M., Perry, G., Harris, P. L., Liu, Y., Schubert, K. A., and Smith, M. A. (2000) In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals J. Neurochem. 74, 270-279
-
(2000)
J. Neurochem.
, vol.74
, pp. 270-279
-
-
Sayre, L.M.1
Perry, G.2
Harris, P.L.3
Liu, Y.4
Schubert, K.A.5
Smith, M.A.6
-
15
-
-
0037462303
-
A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease
-
Shin, R. W., Kruck, T. P., Murayama, H., and Kitamoto, T. (2003) A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer's disease Brain Res. 961, 139-146
-
(2003)
Brain Res.
, vol.961
, pp. 139-146
-
-
Shin, R.W.1
Kruck, T.P.2
Murayama, H.3
Kitamoto, T.4
-
16
-
-
3342879300
-
Molecular shuttle chelation: The use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum
-
Kruck, T. P., Cui, J. G., Percy, M. E., and Lukiw, W. J. (2004) Molecular shuttle chelation: the use of ascorbate, desferrioxamine and Feralex-G in combination to remove nuclear bound aluminum Cell. Mol. Neurobiol. 24, 443-459
-
(2004)
Cell. Mol. Neurobiol.
, vol.24
, pp. 443-459
-
-
Kruck, T.P.1
Cui, J.G.2
Percy, M.E.3
Lukiw, W.J.4
-
17
-
-
0025726462
-
Intramuscular desferrioxamine in patients with Alzheimer's disease
-
Crapper McLachlan, D. R., Dalton, A. J., Kruck, T. P., Bell, M. Y., Smith, W. L., Kalow, W., and Andrews, D. F. (1991) Intramuscular desferrioxamine in patients with Alzheimer's disease Lancet 337, 1304-1308
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crapper McLachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.3
Bell, M.Y.4
Smith, W.L.5
Kalow, W.6
Andrews, D.F.7
-
18
-
-
2942750367
-
Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes
-
Di Vaira, M., Bazzicalupi, C., Orioli, P., Messori, L., Bruni, B., and Zatta, P. (2004) Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes Inorg. Chem. 43, 3795-3797
-
(2004)
Inorg. Chem.
, vol.43
, pp. 3795-3797
-
-
Di Vaira, M.1
Bazzicalupi, C.2
Orioli, P.3
Messori, L.4
Bruni, B.5
Zatta, P.6
-
19
-
-
70350597464
-
Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited
-
Mancino, A. M., Hindo, S. S., Kochi, A., and Lim, M. H. (2009) Effects of clioquinol on metal-triggered amyloid-beta aggregation revisited Inorg. Chem. 48, 9596-9598
-
(2009)
Inorg. Chem.
, vol.48
, pp. 9596-9598
-
-
Mancino, A.M.1
Hindo, S.S.2
Kochi, A.3
Lim, M.H.4
-
20
-
-
18344414746
-
The Aβ peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
-
DOI 10.1021/bi990438f
-
Huang, X., Atwood, C. S., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J., Moir, R. D., Tanzi, R. E., and Bush, A. I. (1999) The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction Biochemistry 38, 7609-7616 (Pubitemid 29289332)
-
(1999)
Biochemistry
, vol.38
, Issue.24
, pp. 7609-7616
-
-
Huang, X.1
Atwood, C.S.2
Hartshorn, M.A.3
Multhaup, G.4
Goldstein, L.E.5
Scarpa, R.C.6
Cuajungco, M.P.7
Gray, D.N.8
Lim, J.9
Moir, R.D.10
Tanzi, R.E.11
Bush, A.I.12
-
21
-
-
24644475272
-
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase
-
Puglielli, L., Friedlich, A. L., Setchell, K. D., Nagano, S., Opazo, C., Cherny, R. A., Barnham, K. J., Wade, J. D., Melov, S., Kovacs, D. M., and Bush, A. I. (2005) Alzheimer disease beta-amyloid activity mimics cholesterol oxidase J. Clin. Invest. 115, 2556-2563
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2556-2563
-
-
Puglielli, L.1
Friedlich, A.L.2
Setchell, K.D.3
Nagano, S.4
Opazo, C.5
Cherny, R.A.6
Barnham, K.J.7
Wade, J.D.8
Melov, S.9
Kovacs, D.M.10
Bush, A.I.11
-
22
-
-
35748959686
-
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands
-
Caragounis, A., Du, T., Filiz, G., Laughton, K. M., Volitakis, I., Sharples, R. A., Cherny, R. A., Masters, C. L., Drew, S. C., Hill, A. F., Li, Q. X., Crouch, P. J., Barnham, K. J., and White, A. R. (2007) Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands Biochem. J. 407, 435-450
-
(2007)
Biochem. J.
, vol.407
, pp. 435-450
-
-
Caragounis, A.1
Du, T.2
Filiz, G.3
Laughton, K.M.4
Volitakis, I.5
Sharples, R.A.6
Cherny, R.A.7
Masters, C.L.8
Drew, S.C.9
Hill, A.F.10
Li, Q.X.11
Crouch, P.J.12
Barnham, K.J.13
White, A.R.14
-
23
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice
-
Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y., Huang, X., Goldstein, L. E., Moir, R. D., Lim, J. T., Beyreuther, K., Zheng, H., Tanzi, R. E., Masters, C. L., and Bush, A. I. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice Neuron 30, 665-676
-
(2001)
Neuron
, vol.30
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
Barnham, K.J.7
Volitakis, I.8
Fraser, F.W.9
Kim, Y.10
Huang, X.11
Goldstein, L.E.12
Moir, R.D.13
Lim, J.T.14
Beyreuther, K.15
Zheng, H.16
Tanzi, R.E.17
Masters, C.L.18
Bush, A.I.19
-
24
-
-
10744224267
-
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial
-
Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., MacGregor, L., Kiers, L., Cherny, R., Li, Q. X., Tammer, A., Carrington, D., Mavros, C., Volitakis, I., Xilinas, M., Ames, D., Davis, S., Beyreuther, K., Tanzi, R. E., and Masters, C. L. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: A pilot phase 2 clinical trial Arch. Neurol. 60, 1685-1691
-
(2003)
Arch. Neurol.
, vol.60
, pp. 1685-1691
-
-
Ritchie, C.W.1
Bush, A.I.2
MacKinnon, A.3
MacFarlane, S.4
Mastwyk, M.5
MacGregor, L.6
Kiers, L.7
Cherny, R.8
Li, Q.X.9
Tammer, A.10
Carrington, D.11
Mavros, C.12
Volitakis, I.13
Xilinas, M.14
Ames, D.15
Davis, S.16
Beyreuther, K.17
Tanzi, R.E.18
Masters, C.L.19
-
25
-
-
0024320494
-
Selective neurotoxicity of clioquinol on the function of the posterior column nuclei
-
Arasaki, K. and Nakanishi, T. (1989) Selective neurotoxicity of clioquinol on the function of the posterior column nuclei Neurosci. Lett. 107, 85-88
-
(1989)
Neurosci. Lett.
, vol.107
, pp. 85-88
-
-
Arasaki, K.1
Nakanishi, T.2
-
26
-
-
67650759968
-
Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy
-
Zheng, H., Youdim, M. B., and Fridkin, M. (2009) Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective- neurorestorative moieties for Alzheimer's therapy J. Med. Chem. 52, 4095-4098
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4095-4098
-
-
Zheng, H.1
Youdim, M.B.2
Fridkin, M.3
-
27
-
-
34248208975
-
Combating Alzheimer's disease with multifunctional molecules designed for metal passivation
-
Schugar, H., Green, D. E., Bowen, M. L., Scott, L. E., Storr, T., Bohmerle, K., Thomas, F., Allen, D. D., Lockman, P. R., Merkel, M., Thompson, K. H., and Orvig, C. (2007) Combating Alzheimer's disease with multifunctional molecules designed for metal passivation Angew. Chem., Int. Ed. 46, 1716-1718
-
(2007)
Angew. Chem., Int. Ed.
, vol.46
, pp. 1716-1718
-
-
Schugar, H.1
Green, D.E.2
Bowen, M.L.3
Scott, L.E.4
Storr, T.5
Bohmerle, K.6
Thomas, F.7
Allen, D.D.8
Lockman, P.R.9
Merkel, M.10
Thompson, K.H.11
Orvig, C.12
-
28
-
-
33749186347
-
A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation
-
Charkoudian, L. K., Pham, D. M., and Franz, K. J. (2006) A pro-chelator triggered by hydrogen peroxide inhibits iron-promoted hydroxyl radical formation J. Am. Chem. Soc. 128, 12424-12425
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 12424-12425
-
-
Charkoudian, L.K.1
Pham, D.M.2
Franz, K.J.3
-
29
-
-
27544471828
-
Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons
-
Zheng, H., Youdim, M. B., Weiner, L. M., and Fridkin, M. (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons Biochem. Pharmacol. 70, 1642-1652
-
(2005)
Biochem. Pharmacol.
, vol.70
, pp. 1642-1652
-
-
Zheng, H.1
Youdim, M.B.2
Weiner, L.M.3
Fridkin, M.4
-
30
-
-
63149091152
-
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease
-
Rodriguez-Rodriguez, C., Sanchez de Groot, N., Rimola, A., Alvarez-Larena, A., Lloveras, V., Vidal-Gancedo, J., Ventura, S., Vendrell, J., Sodupe, M., and Gonzalez-Duarte, P. (2009) Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease J. Am. Chem. Soc. 131, 1436-1451
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 1436-1451
-
-
Rodriguez-Rodriguez, C.1
Sanchez De Groot, N.2
Rimola, A.3
Alvarez-Larena, A.4
Lloveras, V.5
Vidal-Gancedo, J.6
Ventura, S.7
Vendrell, J.8
Sodupe, M.9
Gonzalez-Duarte, P.10
-
31
-
-
64049102869
-
Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease
-
Liu, G., Men, P., Perry, G., and Smith, M. A. (2009) Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease J. Nanoneurosci. 1, 42-55
-
(2009)
J. Nanoneurosci.
, vol.1
, pp. 42-55
-
-
Liu, G.1
Men, P.2
Perry, G.3
Smith, M.A.4
-
32
-
-
77953864734
-
Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy
-
Zheng, H., Youdim, M. B., and Fridkin, M. (2010) Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy ACS Chem. Biol. 5, 603-610
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 603-610
-
-
Zheng, H.1
Youdim, M.B.2
Fridkin, M.3
-
33
-
-
11844255676
-
Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases
-
Zheng, H., Weiner, L. M., Bar-Am, O., Epsztejn, S., Cabantchik, Z. I., Warshawsky, A., Youdim, M. B., and Fridkin, M. (2005) Design, synthesis, and evaluation of novel bifunctional iron-chelators as potential agents for neuroprotection in Alzheimer's, Parkinson's, and other neurodegenerative diseases Bioorg. Med. Chem. 13, 773-783
-
(2005)
Bioorg. Med. Chem.
, vol.13
, pp. 773-783
-
-
Zheng, H.1
Weiner, L.M.2
Bar-Am, O.3
Epsztejn, S.4
Cabantchik, Z.I.5
Warshawsky, A.6
Youdim, M.B.7
Fridkin, M.8
-
34
-
-
25644461154
-
Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: In vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition
-
DOI 10.1111/j.1471-4159.2005.03340.x
-
Zheng, H., Gal, S., Weiner, L. M., Bar-Am, O., Warshawsky, A., Fridkin, M., and Youdim, M. B. (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition J. Neurochem. 95, 68-78 (Pubitemid 41384426)
-
(2005)
Journal of Neurochemistry
, vol.95
, Issue.1
, pp. 68-78
-
-
Zheng, H.1
Gal, S.2
Weiner, L.M.3
Bar-Am, O.4
Warshawsky, A.5
Fridkin, M.6
Youdim, M.B.H.7
-
35
-
-
43249100611
-
Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
-
Amit, T., Avramovich-Tirosh, Y., Youdim, M. B., and Mandel, S. (2008) Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators FASEB J. 22, 1296-1305
-
(2008)
FASEB J.
, vol.22
, pp. 1296-1305
-
-
Amit, T.1
Avramovich-Tirosh, Y.2
Youdim, M.B.3
Mandel, S.4
-
36
-
-
33845879870
-
Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease
-
Avramovich-Tirosh, Y., Amit, T., Bar-Am, O., Zheng, H., Fridkin, M., and Youdim, M. B. (2007) Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease J. Neurochem. 100, 490-502
-
(2007)
J. Neurochem.
, vol.100
, pp. 490-502
-
-
Avramovich-Tirosh, Y.1
Amit, T.2
Bar-Am, O.3
Zheng, H.4
Fridkin, M.5
Youdim, M.B.6
-
37
-
-
34347328257
-
The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates
-
Groner, E., Ashani, Y., Schorer-Apelbaum, D., Sterling, J., Herzig, Y., and Weinstock, M. (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates Mol. Pharmacol. 71, 1610-1617
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 1610-1617
-
-
Groner, E.1
Ashani, Y.2
Schorer-Apelbaum, D.3
Sterling, J.4
Herzig, Y.5
Weinstock, M.6
-
38
-
-
33947235192
-
Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: Application to nitric oxide synthase
-
Maurer, T. and Fung, H. L. (2000) Comparison of methods for analyzing kinetic data from mechanism-based enzyme inactivation: application to nitric oxide synthase AAPS PharmSci 2 E8
-
(2000)
AAPS PharmSci
, vol.2
-
-
Maurer, T.1
Fung, H.L.2
-
39
-
-
73649151319
-
Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase
-
Kitz, R. and Wilson, I. B. (1962) Esters of methanesulfonic acid as irreversible inhibitors of acetylcholinesterase J. Biol. Chem. 237, 3245-3249
-
(1962)
J. Biol. Chem.
, vol.237
, pp. 3245-3249
-
-
Kitz, R.1
Wilson, I.B.2
-
40
-
-
4244058697
-
Simplified experimental route for obtaining Job's curves
-
MacCarthy, P. (1978) Simplified experimental route for obtaining Job's curves Anal. Chem. 50, 2165
-
(1978)
Anal. Chem.
, vol.50
, pp. 2165
-
-
MacCarthy, P.1
-
41
-
-
0015040637
-
Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)
-
Carter, P. (1971) Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine) Anal. Biochem. 40, 450-458
-
(1971)
Anal. Biochem.
, vol.40
, pp. 450-458
-
-
Carter, P.1
-
42
-
-
0015765566
-
Facilitation of Fe(II) autoxidation by Fe(3) complexing agents
-
Harris, D. C. and Aisen, P. (1973) Facilitation of Fe(II) autoxidation by Fe(3) complexing agents Biochim. Biophys. Acta 329, 156-158
-
(1973)
Biochim. Biophys. Acta
, vol.329
, pp. 156-158
-
-
Harris, D.C.1
Aisen, P.2
-
43
-
-
84984088084
-
Hydroxamate Complexes. III. Iron(III) Exchange between Sideramines and Complexones. A Discussion of the Formation Constants of the Hydroxamate Complexes
-
Anderegg, G., L'Eplattenier, F., and Schwarzenbach, G. (1963) Hydroxamate Complexes. III. Iron(III) Exchange between Sideramines and Complexones. A Discussion of the Formation Constants of the Hydroxamate Complexes Helv. Chim. Acta 46, 1409-1422
-
(1963)
Helv. Chim. Acta
, vol.46
, pp. 1409-1422
-
-
Anderegg, G.1
L'Eplattenier, F.2
Schwarzenbach, G.3
-
45
-
-
84881231454
-
-
The ALOGPS 2.1 program
-
The ALOGPS 2.1 program. http://www.vcclab.org/lab/alogps/start.html.
-
-
-
-
46
-
-
0033985927
-
Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease
-
Jann, M. W. (2000) Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease Pharmacotherapy 20, 1-12
-
(2000)
Pharmacotherapy
, vol.20
, pp. 1-12
-
-
Jann, M.W.1
-
47
-
-
34547634202
-
IDEAL: A 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease
-
Winblad, B., Grossberg, G., Froölich, L., Farlow, M., Zechner, S., Nagel, J., and Lane, R. (2007) IDEAL: A 6-month, double-blind, placebo-controlled study of the first skin patch for Alzheimer disease Neurology 69, S14-22
-
(2007)
Neurology
, vol.69
, pp. 14-22
-
-
Winblad, B.1
Grossberg, G.2
Froölich, L.3
Farlow, M.4
Zechner, S.5
Nagel, J.6
Lane, R.7
-
48
-
-
51249118269
-
Monoamine oxidase inactivation: From pathophysiology to therapeutics
-
Bortolato, M., Chen, K., and Shih, J. C. (2008) Monoamine oxidase inactivation: From pathophysiology to therapeutics Adv. Drug Delivery Rev. 60, 1527-1533
-
(2008)
Adv. Drug Delivery Rev.
, vol.60
, pp. 1527-1533
-
-
Bortolato, M.1
Chen, K.2
Shih, J.C.3
-
49
-
-
0029603541
-
Failure of ketoconazole in oriental sore in India
-
Singh, S., Singh, R., and Sundar, S. (1995) Failure of ketoconazole in oriental sore in India J. Chemother. 7 (Suppl 4) 202-203
-
(1995)
J. Chemother.
, vol.7
, Issue.SUPPL. 4
, pp. 202-203
-
-
Singh, S.1
Singh, R.2
Sundar, S.3
-
50
-
-
10344249883
-
Metal-protein attenuating compounds and Alzheimer's disease
-
Ritchie, C. W., Bush, A. I., and Masters, C. L. (2004) Metal-protein attenuating compounds and Alzheimer's disease Expert Opin. Invest. Drugs 13, 1585-1592
-
(2004)
Expert Opin. Invest. Drugs
, vol.13
, pp. 1585-1592
-
-
Ritchie, C.W.1
Bush, A.I.2
Masters, C.L.3
-
51
-
-
33750603844
-
Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Abeta amyloid pathway
-
Masters, C. L. and Beyreuther, K. (2006) Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway Brain 129, 2823-2839
-
(2006)
Brain
, vol.129
, pp. 2823-2839
-
-
Masters, C.L.1
Beyreuther, K.2
-
52
-
-
33745860362
-
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
-
White, A. R., Du, T., Laughton, K. M., Volitakis, I., Sharples, R. A., Xilinas, M. E., Hoke, D. E., Holsinger, R. M., Evin, G., Cherny, R. A., Hill, A. F., Barnham, K. J., Li, Q. X., Bush, A. I., and Masters, C. L. (2006) Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity J. Biol. Chem. 281, 17670-17680
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 17670-17680
-
-
White, A.R.1
Du, T.2
Laughton, K.M.3
Volitakis, I.4
Sharples, R.A.5
Xilinas, M.E.6
Hoke, D.E.7
Holsinger, R.M.8
Evin, G.9
Cherny, R.A.10
Hill, A.F.11
Barnham, K.J.12
Li, Q.X.13
Bush, A.I.14
Masters, C.L.15
-
53
-
-
0021337104
-
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site
-
Graf, E., Mahoney, J. R., Bryant, R. G., and Eaton, J. W. (1984) Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site J. Biol. Chem. 259, 3620-3624
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 3620-3624
-
-
Graf, E.1
Mahoney, J.R.2
Bryant, R.G.3
Eaton, J.W.4
-
54
-
-
33747889345
-
The effect of metal chelators on the production of hydroxyl radicals in thylakoids
-
Snyrychova, I., Pospisil, P., and Naus, J. (2006) The effect of metal chelators on the production of hydroxyl radicals in thylakoids Photosynth. Res. 88, 323-329
-
(2006)
Photosynth. Res.
, vol.88
, pp. 323-329
-
-
Snyrychova, I.1
Pospisil, P.2
Naus, J.3
-
55
-
-
0036710931
-
Lipid peroxidation in aging brain and Alzheimer's disease
-
Montine, T. J., Neely, M. D., Quinn, J. F., Beal, M. F., Markesbery, W. R., Roberts, L. J., and Morrow, J. D. (2002) Lipid peroxidation in aging brain and Alzheimer's disease Free Radical Biol. Med. 33, 620-626
-
(2002)
Free Radical Biol. Med.
, vol.33
, pp. 620-626
-
-
Montine, T.J.1
Neely, M.D.2
Quinn, J.F.3
Beal, M.F.4
Markesbery, W.R.5
Roberts, L.J.6
Morrow, J.D.7
-
56
-
-
0034721135
-
3,5-Disubstituted-4-hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1 H)-pyridinone: Potent inhibitors of lipid peroxidation and cell toxicity
-
Bebbington, D., Monck, N. J., Gaur, S., Palmer, A. M., Benwell, K., Harvey, V., Malcolm, C. S., and Porter, R. H. (2000) 3,5-Disubstituted-4- hydroxyphenyls linked to 3-hydroxy-2-methyl-4(1 H)-pyridinone: Potent inhibitors of lipid peroxidation and cell toxicity J. Med. Chem. 43, 2779-2782
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2779-2782
-
-
Bebbington, D.1
Monck, N.J.2
Gaur, S.3
Palmer, A.M.4
Benwell, K.5
Harvey, V.6
Malcolm, C.S.7
Porter, R.H.8
-
57
-
-
77951607880
-
Antioxidant activities of curcumin and combinations of this curcuminoid with other phytochemicals
-
Aftab, N. and Vieira, A. (2010) Antioxidant activities of curcumin and combinations of this curcuminoid with other phytochemicals Phytother Res. 24, 500-502
-
(2010)
Phytother Res.
, vol.24
, pp. 500-502
-
-
Aftab, N.1
Vieira, A.2
-
58
-
-
0029449149
-
Therapeutic iron chelators and their potential side-effects
-
Singh, S., Khodr, H., Taylor, M. I., and Hider, R. C. (1995) Therapeutic iron chelators and their potential side-effects Biochem. Soc. Symp. 61, 127-137
-
(1995)
Biochem. Soc. Symp.
, vol.61
, pp. 127-137
-
-
Singh, S.1
Khodr, H.2
Taylor, M.I.3
Hider, R.C.4
-
59
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
Lipinski, C. A., Lombardo, F., Dominy, B. W., and Feeney, P. J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Delivery Rev. 46, 3-26 (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
60
-
-
0346849912
-
Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats
-
Shachar, D. B., Kahana, N., Kampel, V., Warshawsky, A., and Youdim, M. B. (2004) Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats Neuropharmacology 46, 254-263
-
(2004)
Neuropharmacology
, vol.46
, pp. 254-263
-
-
Shachar, D.B.1
Kahana, N.2
Kampel, V.3
Warshawsky, A.4
Youdim, M.B.5
-
61
-
-
0015040637
-
Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)
-
Carter, P. (1971) Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine) Anal. Biochem. 40, 450-458
-
(1971)
Anal. Biochem.
, vol.40
, pp. 450-458
-
-
Carter, P.1
|