Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 14-18

  Davis, Rohan A ^a   Innocenti, Alessio ^b   Poulsen, Sally Ann ^a   Supuran, Claudiu T ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Mitochondrial isoforms; Natural product; Phenols; Selective enzyme inhibitors

Indexed keywords

4 HYDROXY 3 CHLOROPHENYLACETAMIDE; AMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE VA; CARBONATE DEHYDRATASE VB; DIHYDROGUAIARETIC ACID; ENDIANDRIN A; ENDIANDRIN B; PHENOL DERIVATIVE; POLYANDROCARPAMINE A; POLYANDROCARPAMINE B; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; XYLARIAMIDE A;

ARTICLE; CYTOSOL; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GLUCONEOGENESIS; LIPOGENESIS; MITOCHONDRION; UREA CYCLE;

CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CYTOSOL; HUMANS; ISOENZYMES; MITOCHONDRIA; MOLECULAR STRUCTURE; PHENOLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049112279     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.021     Document Type: Article

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