6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 5, 2014, Pages 1256-1260

  Grandane, Aiga ^a   Tanc, Muhammet ^b   Zalubovskis, Raivis ^a   Supuran, Claudiu T ^b  

^a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS   (Latvia)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

1,4 Substituted 1,2,3 triazole; 1,5 Substituted 1,2,3 triazole; Carbonic anhydrase; Click chemistry; Isoform selective inhibitor; Sulfocoumarin; Tumor associated carbonic anhydrase

Indexed keywords

1,4-SUBSTITUTED 1,2,3-TRIAZOLE; 1,5-SUBSTITUTED 1,2,3-TRIAZOLE; CARBONIC ANHYDRASE; CLICK CHEMISTRY; ISOFORM-SELECTIVE INHIBITOR; SULFOCOUMARIN; TUMOR-ASSOCIATED CARBONIC ANHYDRASE;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COUMARINS; ENZYME ACTIVATION; HUMANS; NEOPLASMS; PROTEIN BINDING; TRIAZOLES;

EID: 84894567311     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.076     Document Type: Article

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