Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo

Journal of Medicinal Chemistry

Volumn 56, Issue 11, 2013, Pages 4691-4700

  Carta, Fabrizio ^a   Akdemir, Atilla ^b   Scozzafava, Andrea ^a   Masini, Emanuela ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b BEZMIALEM VAKIF UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 DIMETHYLAMINO ETHOXY) ETHANOL; 2 (PYRIDIN 2 YL)ETHAN 1 OL; 2 DIMETHYLAMINOETHAN 1 OL; 2,2 DIPHENYL ETHANOL 1; 3 METHYL BUTAN 1 OL; ADAMANTANE ETHYL 1 OL; ADAMANTANE METHYL 1 OL; ALCOHOL; ANTIGLAUCOMA AGENT; BENZYL ALCOHOL; BENZYLMERCAPTAN; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; CYANAMIDE; CYCLOHEXAN 1 OL; CYCLOPENTAN 1 OL; DITHIOCARBAMIC ACID; METHANOL; OCTANOL; PENTANOL; TERT BUTYL 4 HYDROXYBUTYLCARBAMATE; TERT BUTYL 6 HYDROXYHEXYLCARBAMATE; UNCLASSIFIED DRUG; XANTHIC ACID DERIVATIVE; ZINC ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE TARGETING; GLAUCOMA; HUMAN; IN VIVO STUDY; MALE; NONHUMAN;

ANIMALS; ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE I; CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CATALYTIC DOMAIN; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; ISOENZYMES; MALE; MODELS, MOLECULAR; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOCARBAMATES;

EID: 84879051423     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400414j     Document Type: Article

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