Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 7, 2012, Pages 2266-2273

  Carta, Fabrizio ^a   Maresca, Alfonso ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Carbonic anhydrase; Coumarin; Selective inhibition; Transmembrane isoform; Tumor associated enzyme

Indexed keywords

1 (3',5' DIMETHYLPHENYL) 3 (4 METHYL 2 OXO 2H CHROMEN 7 YL)UREA; 2 THIOXO COUMARIN DERIVATIVE; 2' (2 OXO 2H CHROMEN 7 YLOXY)ETHYL 4'' METHYLBENZENESULFONATE; 4 (ALLYLOXY) 2H CHROMEN 2 ONE; 4 (ALLYLOXY) 2H CHROMENE 2 THIONE; 6 (ALLYLOXY) 2H CHROMEN 2 ONE; 6 (ALLYLOXY) 2H CHROMENE 2 THIONE; 6 (TERT BUTYLDIMETHYLSILYLOXY) 2H CHROMEN 2 ONE; 6 (TERT BUTYLDIMETHYLSILYLOXY) 2H CHROMENE 2 THIONE; 6 HYDROXY 2H CHROMENE 2 THIONE; 7 (2' FLUOROETHOXY) 2H CHROMEN 2 ONE; 7 (2' HYDROXYETHOXY) 2H CHROMEN 2 ONE; 7 (ALLYLOXY) 2H CHROMEN 2 ONE; 7 (ALLYLOXY) 2H CHROMENE 2 THIONE; 7 (TERT BUTYLDIMETHYLSILYLOXY) 2H CHROMEN 2 ONE; 7 (TERT BUTYLDIMETHYLSILYLOXY) 2H CHROMENE 2 THIONE; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; COUMARIN DERIVATIVE; MEMBRANE PROTEIN; N (4 METHYL 2 OXO 2H CHROMEN 7 YL)ACETAMIDE; TERT BUTYL 4 METHYL 2 OXO 2H CHROMEN 7 YLCARBAMATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR;

ANTIGENS, NEOPLASM; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; COUMARINS; HUMANS; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858288806     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.02.014     Document Type: Article

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