Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways

Immunological Reviews

Volumn 265, Issue 1, 2015, Pages 181-193

  Monie, Tom P ^a   Bryant, Clare E ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Apoptosis; Caspase; Death receptor; Inflammasome; Interleukin 1 ; Signal transduction

Indexed keywords

CASPASE 8; INFLAMMASOME; INTERLEUKIN 1BETA; REGULATOR PROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, HUMAN;

APOPTOSIS; CELL DEATH; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; INFLAMMATION; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; VIRUS; VIRUS VIRULENCE; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM;

ANIMALS; CASPASE 8; CELL DEATH; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84927729737     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12284     Document Type: Review

References (90)

1. Rodrigue-Gervais IG, Saleh M. Caspases and immunity in a deadly grip. Trends Immunol 2013;34:41-49.
2. Varfolomeev EE, et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 1998;9:267-276.
3. Kaiser WJ, et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 2011;471:368-372.
4. Oberst A, et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011;471:363-367.
5. Zhao Y, Sui X, Ren H. From procaspase-8 to caspase-8: revisiting structural functions of caspase-8. J Cell Physiol 2010;225:316-320.
6. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013;38:209-223.
7. Morizot A, Saleh M. Non-apoptotic functions of cell death effectors in inflammation and innate immunity. Microbes Infect 2012;14:1241-1253.
8. Khan N, Lawlor KE, Murphy JM, Vince JE. More to life than death: molecular determinants of necroptotic and non-necroptotic RIP3 kinase signaling. Curr Opin Immunol 2014;26:76-89.
9. Vandenabeele P, Galluzzi L, Berghe T, Vanden Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010;11:700-714.
10. Dickens LS, Powley IR, Hughes MA, Macfarlane M. The "complexities" of life and death: death receptor signalling platforms. Exp Cell Res 2012;318:1269-1277.
11. Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M. Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival. Mol Cell 2009;35:265-279.
12. Oberst A, et al. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem 2010;285:16632-16642.
13. Peter ME. The flip side of FLIP. Biochem J 2004;382:e1-e3.
14. Varfolomeev E, et al. Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. J Biol Chem 2005;280:40599-40608.
15. Lavrik IN, Mock T, Golks A, Hoffmann JC, Baumann S, Krammer PH. CD95 stimulation results in the formation of a novel death effector domain protein-containing complex. J Biol Chem 2008;283:26401-26408.
16. Kallenberger SM, et al. Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal 2014;7:ra23.
17. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003;114:181-190.
18. Vince JE, et al. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 2012;36:215-227.
19. Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012;148:213-227.
20. Wang Z, Jiang H, Chen S, Du F, Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012;148:228-243.
21. Wang H, et al. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Mol Cell 2014;54:133-146.
22. Davis BK, Wen H, Ting JP-Y. The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 2011;29:707-735.
23. Lamkanfi M, Dixit VM. Mechanisms and functions of inflammasomes. Cell 2014;157:1013-1022.
24. Sutterwala FS, Haasken S, Cassel SL. Mechanism of NLRP3 inflammasome activation. Ann N Y Acad Sci 2014;1319:82-95.
25. Schroder K, Tschopp J. The inflammasomes. Cell 2010;140:821-832.
26. Franchi L, Muñoz-Planillo R, Núñez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol 2012;13:325-332.
27. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-426.
28. Srinivasula SM, Poyet J-L, Razmara M, Datta P, Zhang Z, Alnemri ES. The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem 2002;277:21119-21122.
29. Fink SL, Cookson BT. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Micro 2006;8:1812.
30. Fernandes-Alnemri T, et al. The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation. Cell Death Differ 2007;14:1590-1604.
31. Masumoto J, et al. ASC, a Novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem 1999;274:33835-33838.
32. Masumoto J, et al. ASC is an activating adaptor for NF-B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun 2003;303:69-73.
33. Motshwene PG, et al. An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J Biol Chem 2009;284:25404-25411.
34. Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010;465:885-890.
35. Park HH, et al. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 2007;128:533-546.
36. Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell 2002;9:423-432.
37. Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y. Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1. Nature 1999;399:549-557.
38. Jang T, et al. Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment. Biochemistry 2014;53:5424-5431.
39. Tenev T, et al. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011;43:432-448.
40. Wang L, et al. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol 2010;17:1324-1329.
41. Scott FL, et al. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 2009;457:1019-1022.
42. Motani K, Kawase K, Imamura R, Kinoshita T, Kushiyama H, Suda T. Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer Sci 2010;101:1822-1827.
43. Hasegawa M, et al. Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells. Oncogene 2007;26:1748-1756.
44. Motani K, Kushiyama H, Imamura R, Kinoshita T, Nishiuchi T, Suda T. Caspase-1 induces apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC)-mediated necrosis independently of its catalytic activity. J Biol Chem 2011;286:33963-33972.
45. Kumar Y, Radha V, Swarup G. Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death. Biochem J 2010;427:91-104.
46. Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti T-D, Lamkanfi M. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun 2014;5:3209.
47. Mariathasan S, et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004;430:213-218.
48. Broz P, von Moltke J, Jones JW, Vance RE, Monack DM. Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 2010;8:471-483.
49. Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009;27:519-550.
50. Dinarello CA, van der Meer JWM. Treating inflammation by blocking interleukin-1 in humans. Semin Immunol 2013;25:469-484.
51. Miwa K, Asano M, Horai R, Iwakura Y, Nagata S, Suda T. Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand. Nat Med 1998;4:1287-1292.
52. Shimada K, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012;36:401-414.
53. Maelfait J, et al. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med 2008;205:1967-1973.
54. Bossaller L, et al. Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. J Immunol 2012;189:5508-5512.
55. England H, Summersgill HR, Edye ME, Rothwell NJ, Brough D. Release of interleukin-1α or interleukin-1β depends on mechanism of cell death. J Biol Chem 2014;289:15942-15950.
56. Antonopoulos C, El Sanadi C, Kaiser WJ, Mocarski ES, Dubyak GR. Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells. J Immunol 2013;191:4789-4803.
57. Hazuda DJ, Strickler J, Kueppers F, Simon PL, Young PR. Processing of precursor interleukin 1 beta and inflammatory disease. J Biol Chem 1990;265:6318-6322.
58. Gringhuis SI, et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat Immunol 2012;13:246-254.
59. Ganesan S, et al. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans. J Immunol 2014;193:2519-2530.
60. Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol 2013;191:5239-5246.
61. Philip NH, et al. Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling. Proc Natl Acad Sci USA 2014;111:7385-7390.
62. Weng D, et al. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci USA 2014;111:7391-7396.
63. Gurung P, et al. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol 2014;192:1835-1846.
64. Wu Y-H, et al. Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation. Cell Death Differ 2014;21:451-461.
65. Pierini R, et al. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death Differ 2012;19:1709-1721.
66. Sagulenko V, et al. AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death Differ 2013;20:1149-1160.
67. Kang T, Yang S, Toth B, Kovalenko A, Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 2013;38:27-40.
68. Man SM, et al. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc Natl Acad Sci USA 2014;111:7403-7408.
69. Dickens LS, et al. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol Cell 2012;95:1-15.
70. Siegel RM, et al. Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis. J Cell Biol 1998;141:1243-1253.
71. Lu A, et al. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 2014;156:1193-1206.
72. Kovalenko A, et al. Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease. J Exp Med 2009;206:2161-2177.
73. Ben Moshe T, et al. Role of caspase-8 in hepatocyte response to infection and injury in mice. Hepatology 2007;45:1014-1024.
74. Günther C, et al. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature 2011;477:335-339.
75. Kim Y, et al. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci USA 2014;111:16082-16087.
76. Chi W, et al. Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1β production in acute glaucoma. Proc Natl Acad Sci USA 2014;111:11181-11186.
77. Burguillos MA, et al. Caspase signalling controls microglia activation and neurotoxicity. Nature 2011;472:319-324.
78. Muzio M, Salvesen GS, Dixit VM. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J Biol Chem 1997;272:2952-2956.
79. Mocarski ES, Upton JW, Kaiser WJ. Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol 2012;12:79-88.
80. Taylor JM, Barry M. Near death experiences: poxvirus regulation of apoptotic death. Virology 2006;344:139-150.
81. Chen P, Tian J, Kovesdi I, Bruder JT. Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis. J Biol Chem 1998;273:5815-5820.
82. Clem RJ, Fechheimer M, Miller LK. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 1991;254:1388-1390.
83. McCormick AL. Control of apoptosis by human cytomegalovirus. Curr Top Microbiol Immunol 2008;325:281-295.
84. Lagunoff M, Carroll PA. Inhibition of apoptosis by the gamma-herpesviruses. Int Rev Immunol 2013;22:373-399.
85. Callus BA, Vaux DL. Caspase inhibitors: viral, cellular and chemical. Cell Death Differ 2007;14:73-78.
86. Upton JW, Kaiser WJ, Mocarski ES. Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe 2010;7:302-313.
87. Rajput A, et al. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 2011;34:340-351.
88. Michallet M-C, et al. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 2008;28:651-661.
89. Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol 2006;176:4520-4524.
90. de Alba E. Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC). J Biol Chem 2009;284:32932-32941.