Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans

Journal of Immunology

Volumn 193, Issue 5, 2014, Pages 2519-2530

  Ganesan, Sandhya ^a   Rathinam, Vijay A K ^a,h   Bossaller, Lukas ^a,b   Army, Kelly ^a   Kaiser, William J ^c   Mocarski, Edward S ^c   Dillon, Christopher P ^d   Green, Douglas R ^d   Mayadas, Tanya N ^e   Levitz, Stuart M ^a   Hise, Amy G ^f,g   Silverman, Neal ^a   Fitzgerald, Katherine A ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^h UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCAN; CASPASE 8; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR 3; CRYOPYRIN; DECTIN 1; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG; CARRIER PROTEIN; CASP8 PROTEIN, MOUSE; CD11B ANTIGEN; CIAS1 PROTEIN, MOUSE; FUNGAL POLYSACCHARIDE; IL1B PROTEIN, MOUSE; LECTIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVITY; ENZYME REGULATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; ANIMAL; CANDIDIASIS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY;

ANIMALS; BETA-GLUCANS; CANDIDA ALBICANS; CANDIDIASIS; CARRIER PROTEINS; CASPASE 8; CELL DEATH; DENDRITIC CELLS; FUNGAL POLYSACCHARIDES; HUMANS; INTERLEUKIN-1BETA; LECTINS, C-TYPE; MACROPHAGE-1 ANTIGEN; MICE; MICE, KNOCKOUT;

EID: 84907033643     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400276     Document Type: Article

References (78)

1. Brown, G. D., D. W. Denning, N. A. R. Gow, S. M. Levitz, M. G. Netea, and T. C. White. 2012. Hidden killers: human fungal infections. Sci. Transl. Med. 4: 165rv13.
2. Hise, A. G., J. Tomalka, S. Ganesan, K. Patel, B. A. Hall, G. D. Brown, and K. A. Fitzgerald. 2009. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 5: 487-497.
3. Stuyt, R. J., M. G. Netea, I. Verschueren, G. Fantuzzi, C. A. Dinarello, J. W. Van Der Meer, and B. J. Kullberg. 2002. Role of interleukin-18 in host defense against disseminated Candida albicans infection. Infect. Immun. 70: 3284-3286.
4. Stuyt, R. J., M. G. Netea, J. H. van Krieken, J. W. van der Meer, and B. J. Kullberg. 2004. Recombinant interleukin-18 protects against disseminated Candida albicans infection in mice. J. Infect. Dis. 189: 1524-1527.
5. Vonk, A. G., M. G. Netea, J. H. van Krieken, Y. Iwakura, J. W. M. van der Meer, and B. J. Kullberg. 2006. Endogenous interleukin (IL)-1α and IL-1β are crucial for host defense against disseminated candidiasis. J. Infect. Dis. 193: 1419-1426.
6. Chung, Y., S. H. Chang, G. J. Martinez, X. O. Yang, R. Nurieva, H. S. Kang, L. Ma, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30: 576-587.
7. Lasigliè, D., E. Traggiai, S. Federici, M. Alessio, A. Buoncompagni, A. Accogli, S. Chiesa, F. Penco, A. Martini, and M. Gattorno. 2011. Role of IL-1β in the development of human T(H)17 cells: lesson from NLPR3 mutated patients. PLoS One 6: e20014-e20014.
8. Conti, H. R., F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, J. H. Hai, J. J. Yu, J. W. Jung, et al. 2009. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J. Exp. Med. 206: 299-311.
9. Netea, M. G., R. J. L. Stuyt, S.-H. Kim, J. W. M. Van der Meer, B. J. Kullberg, and C. A. Dinarello. 2002. The role of endogenous interleukin (IL)-18, IL-12, IL-1beta;, and tumor necrosis factor-α in the production of interferon-g induced by Candida albicans in human whole-blood cultures. J. Infect. Dis. 185: 963-970.
10. Rathinam, V. A. K., S. K. Vanaja, and K. A. Fitzgerald. 2012. Regulation of inflammasome signaling. Nat. Immunol. 13: 333-342.
11. Gross, O., H. Poeck, M. Bscheider, C. Dostert, N. Hannesschläger, S. Endres, G. Hartmann, A. Tardivel, E. Schweighoffer, V. Tybulewicz, et al. 2009. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459: 433-436.
12. Tomalka, J., S. Ganesan, E. Azodi, K. Patel, P. Majmudar, B. A. Hall, K. A. Fitzgerald, and A. G. Hise. 2011. A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans. PLoS Pathog. 7: e1002379.
13. Joly, S., S. C. Eisenbarth, A. K. Olivier, A. Williams, D. H. Kaplan, S. L. Cassel, R. A. Flavell, and F. S. Sutterwala. 2012. Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans. J. Immunol. 189: 4713-4717.
14. Levitz, S. M. 2010. Innate recognition of fungal cell walls. PLoS Pathog. 6: e1000758.
15. Gow, N. A., and B. Hube. 2012. Importance of the Candida albicans cell wall during commensalism and infection. Curr. Opin. Microbiol. 15: 406-412.
16. Mori, T., H. Ikemoto, M. Matsumura, M. Yoshida, K. Inada, S. Endo, A. Ito, S. Watanabe, H. Yamaguchi, M. Mitsuya, et al. 1997. Evaluation of plasma (1→3)-β-D-glucan measurement by the kinetic turbidimetric Limulus test, for the clinical diagnosis of mycotic infections. Eur. J. Clin. Chem. Clin. Biochem. 35: 553-560.
17. Miyazaki, T., S. Kohno, K. Mitsutake, S. Maesaki, K. Tanaka, N. Ishikawa, and K. Hara. 1995. Plasma (1→3)-β-D-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis. J. Clin. Microbiol. 33: 3115-3118.
18. Karageorgopoulos, D. E., E. K. Vouloumanou, F. Ntziora, A. Michalopoulos, P. I. Rafailidis, and M. E. Falagas. 2011. β-D-Glucan assay for the diagnosis of invasive fungal infections: a meta-analysis. Clin. Infect. Dis. 52: 750-770.
19. Gringhuis, S. I., T. M. Kaptein, B. A. Wevers, B. Theelen, M. van der Vlist, T. Boekhout, and T. B. H. Geijtenbeek. 2012. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat. Immunol. 13: 246-254.
20. Kankkunen, P., L. Teirilä, J. Rintahaka, H. Alenius, H. Wolff, and S. Matikainen. 2010. (1,3)-β-Glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages. J. Immunol. 184: 6335-6342.
21. Kumar, H., Y. Kumagai, T. Tsuchida, P. A. Koenig, T. Satoh, Z. Guo, M. H. Jang, T. Saitoh, S. Akira, and T. Kawai. 2009. Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal β-glucan. J. Immunol. 183: 8061-8067.
22. Bossaller, L., P. I. Chiang, C. Schmidt-Lauber, S. Ganesan, W. J. Kaiser, V. A. Rathinam, E. S. Mocarski, D. Subramanian, D. R. Green, N. Silverman, et al. 2012. Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner. J. Immunol. 189: 5508-5512.
23. Maelfait, J., E. Vercammen, S. Janssens, P. Schotte, M. Haegman, S. Magez, and R. Beyaert. 2008. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8. J. Exp. Med. 205: 1967-1973.
24. Kayagaki, N., S. Warming, M. Lamkanfi, L. Vande Walle, S. Louie, J. Dong, K. Newton, Y. Qu, J. Liu, S. Heldens, et al. 2011. Non-canonical inflammasome activation targets caspase-11. Nature 479: 117-121.
25. Rathinam, V. A. K., S. K. Vanaja, L. Waggoner, A. Sokolovska, C. Becker, L. M. Stuart, J. M. Leong, and K. A. Fitzgerald. 2012. TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell 150: 606-619.
26. Man, S. M., P. Tourlomousis, L. Hopkins, T. P. Monie, K. A. Fitzgerald, and C. E. Bryant. 2013. Salmonella infection induces recruitment of caspase-8 to the inflammasome to modulate IL-1β production. J. Immunol. 191: 5239-5246.
27. Antonopoulos, C., C. El Sanadi, W. J. Kaiser, E. S. Mocarski, and G. R. Dubyak. 2013. Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells. J. Immunol. 191: 4789-4803.
28. Varfolomeev, E. E., M. Schuchmann, V. Luria, N. Chiannilkulchai, J. S. Beckmann, I. L. Mett, D. Rebrikov, V. M. Brodianski, O. C. Kemper, O. Kollet, et al. 1998. Targeted disruption of the mouse caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9: 267-276.
29. Kaiser, W. J., J. W. Upton, A. B. Long, D. Livingston-Rosanoff, L. P. Daley-Bauer, R. Hakem, T. Caspary, and E. S. Mocarski. 2011. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471: 368-372.
30. Oberst, A., C. P. Dillon, R. Weinlich, L. L. McCormick, P. Fitzgerald, C. Pop, R. Hakem, G. S. Salvesen, and D. R. Green. 2011. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471: 363-367.
31. Hara, H., C. Ishihara, A. Takeuchi, T. Imanishi, L. Xue, S. W. Morris, M. Inui, T. Takai, A. Shibuya, S. Saijo, et al. 2007. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat. Immunol. 8: 619-629.
32. Coxon, A., P. Rieu, F. J. Barkalow, S. Askari, A. H. Sharpe, U. H. von Andrian, M. A. Arnaout, and T. N. Mayadas. 1996. A novel role for the b2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5: 653-666.
33. Taylor, P. R., S. V. Tsoni, J. A. Willment, K. M. Dennehy, M. Rosas, H. Findon, K. Haynes, C. Steele,M.Botto, S.Gordon, andG.D.Brown. 2007. Dectin-1 is required for β-glucan recognition and control of fungal infection. Nat. Immunol. 8: 31-38.
34. Cheng, S. C., F. L. van de Veerdonk, M. Lenardon, M. Stoffels, T. Plantinga, S. Smeekens, L. Rizzetto, L. Mukaremera, K. Preechasuth, D. Cavalieri, et al. 2011. The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans. J. Leukoc. Biol. 90: 357-366.
35. Rathinam, V. A. K., K. A. Hoag, and L. S. Mansfield. 2008. Dendritic cells from C57BL/6 mice undergo activation and induce Th1-effector cell responses against Campylobacter jejuni. Microbes Infect. 10: 1316-1324.
36. Gow, N. A. R., M. G. Netea, C. A. Munro, G. Ferwerda, S. Bates, H. M. Mora-Montes, L. Walker, T. Jansen, L. Jacobs, V. Tsoni, et al. 2007. Immune recognition of Candida albicans β-glucan by dectin-1. J. Infect. Dis. 196: 1565-1571.
37. Klis, F. M., P. de Groot, and K. Hellingwerf. 2001. Molecular organization of the cell wall of Candida albicans. Med. Mycol. 39(Suppl. 1): 1-8.
38. Klis, F. M., P. Mol, K. Hellingwerf, and S. Brul. 2002. Dynamics of cell wall structure in Saccharomyces cerevisiae. FEMS Microbiol. Rev. 26: 239-256.
39. Gopal, P. K., M. G. Shepherd, and P. A. Sullivan. 1984. Analysis of wall glucans from yeast, hyphal and germ-tube forming cells of Candida albicans. J. Gen. Microbiol. 130: 3295-3301.
40. Manners, D. J., A. J. Masson, and J. C Patterson. 1973. The structure of a beta-(1-.3)-D-glucan from yeast cell walls. Biochem. J. 135: 19-30.
41. Kuida, K., J. A. Lippke, G. Ku, M.W. Harding, D. J. Livingston, M. S. S. Su, and R. A. Flavell. 1995. Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267: 2000-2003.
42. Li, P., H. Allen, S. Banerjee, S. Franklin, L. Herzog, C. Johnston, J. McDowell, M. Paskind, L. Rodman, J. Salfeld, et al. 1995. Mice deficient in IL-1 betaconverting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80: 401-411.
43. 2010. CM-curdlan activity 2. 1-7.
44. Bueter, C. L., C. K. Lee, V. A. Rathinam, G. J. Healy, C. H. Taron, C. A. Specht, and S. M. Levitz. 2011. Chitosan but not chitin activates the inflammasome by a mechanism dependent upon phagocytosis. J. Biol. Chem. 286: 35447-35455.
45. Kim, M.-J., S.-Y. Hong, S.-K. Kim, C. Cheong, H.-J. Park, H.-K. Chun, K.-H. Jang, B.-D. Yoon, C.-H. Kim, and S. A. Kang. 2009. β-Glucan enhanced apoptosis in human colon cancer cells SNU-C4. Nutr. Res. Pract. 3: 180-184.
46. Jouault, T., M. El Abed-El Behi, M. Martínez-Esparza, L. Breuilh, P.-A. Trinel, M. Chamaillard, F. Trottein, and D. Poulain. 2006. Specific recognition of Candida albicans by macrophages requires galectin-3 to discriminate Saccharomyces cerevisiae and needs association with TLR2 for signaling. J. Immunol. 177: 4679-4687.
47. Esteban, A., M. W. Popp, V. K. Vyas, K. Strijbis, H. L. Ploegh, and G. R. Fink. 2011. Fungal Recognition Is Mediated by the Association Of Dectin-1 and Galectin-3 in Macrophages, Vol. 108. National Academy Press, Washington, DC, p. 14270-14275.
48. Wells, C. A., J. A. Salvage-Jones, X. Li, K. Hitchens, S. Butcher, R. Z. Murray, A. G. Beckhouse, Y. L. S. Lo, S. Manzanero, C. Cobbold, et al. 2008. The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J. Immunol. 180: 7404-7413.
49. Wileman, T. E., M. R. Lennartz, and P. D. Stahl. 1986. Identification of the macrophage mannose receptor as a 175-kDa membrane protein. Proc. Natl. Acad. Sci. USA 83: 2501-2505.
50. Stephenson, J. D., and V. L. Shepherd. 1987. Purification of the human alveolar macrophage mannose receptor. Biochem. Biophys. Res. Commun. 148: 883-889.
51. Stahl, P. D., J. S. Rodman, M. J. Miller, and P. H. Schlesinger. 1978. Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages. Proc. Natl. Acad. Sci. USA 75: 1399-1403.
52. Li, X., A. Utomo, X. Cullere, M. M. Choi, D. A. Milner, Jr., D. Venkatesh, S.-H. Yun, and T. N. Mayadas. 2011. The β-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe 10: 603-615.
53. Lemmers, B., L. Salmena, N. Bidère, H. Su, E. Matysiak-Zablocki, K. Murakami, P. S. Ohashi, A. Jurisicova, M. Lenardo, R. Hakem, and A. Hakem. 2007. Essential role for caspase-8 in Toll-like receptors and NFκB signaling. J. Biol. Chem. 282: 7416-7423.
54. Takahashi, K., T. Kawai, H. Kumar, S. Sato, S. Yonehara, and S. Akira. 2006. Roles of caspase-8 and caspase-10 in innate immune responses to doublestranded RNA. J. Immunol. 176: 4520-4524.
55. Chun, H. J., L. Zheng, M. Ahmad, J. Wang, C. K. Speirs, R. M. Siegel, J. K. Dale, J. Puck, J. Davis, C. G. Hall, et al, 2002. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419: 395-399.
56. Ch'en, I. L., D. R. Beisner, A. Degterev, C. Lynch, J. Yuan, A. Hoffmann, and S. M. Hedrick. 2008. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proc. Natl. Acad. Sci. USA 105: 17463-17468.
57. Beisner, D. R., I. L. Ch'en, R. V. Kolla, A. Hoffmann, and S. M. Hedrick. 2005. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J. Immunol. 175: 3469-3473.
58. Ferwerda, G., F. Meyer-Wentrup, B. J. Kullberg, M. G. Netea, and G. J. Adema. 2008. Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages. Cell. Microbiol. 10: 2058-2066.
59. Weng, D., R. Marty-Roix, S. Ganesan, M. K. Proulx, G. I. Vladimer, W. J. Kaiser, E. S. Mocarski, K. Pouliot, F. K. M. Chan, M. A. Kelliher, et al. 2014. Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc. Natl. Acad. Sci. USA 111: 7391-7396.
60. Gurung, P., P. K. Anand, R. K. S. Malireddi, L. Vande Walle, N. Van Opdenbosch, C. P. Dillon, R. Weinlich, D. R. Green, M. Lamkanfi, and T. D. Kanneganti. 2014. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J. Immunol. 192: 1835-1846.
61. Shenderov, K., N. Riteau, R. Yip, K. D. Mayer-Barber, S. Oland, S. Hieny, P. Fitzgerald, A. Oberst, C. P. Dillon, D. R. Green, et al. 2014. Cutting edge: endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8-and TRIF-dependent pathway. J. Immunol. 192: 2029-2033.
62. Rajput, A., A. Kovalenko, K. Bogdanov, S.-H. Yang, T.-B. Kang, J.-C. Kim, J. Du, and D. Wallach. 2011. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 34: 340-351.
63. Guarda, G., M. Braun, F. Staehli, A. Tardivel, C. Mattmann, I. Förster, M. Farlik, T. Decker, R. A. Du Pasquier, P. Romero, and J. Tschopp. 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34: 213-223.
64. Wheeler, R. T., D. Kombe, S. D. Agarwala, and G. R. Fink. 2008. Dynamic, morphotype-specific Candida albicans β-glucan exposure during infection and drug treatment. PLoS Pathog. 4: e1000227.
65. Zhang, B., J. Hirahashi, X. Cullere, and T. N. Mayadas. 2003. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: crosstalk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J. Biol. Chem. 278: 28443-28454.
66. Labbé, K., C. R. McIntire, K. Doiron, P. M. Leblanc, and M. Saleh. 2011. Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity 35: 897-907.
67. Paquette, N., M. Broemer, K. Aggarwal, L. Chen, M. Husson, D. Ertüurk-Hasdemir, J.-M. Reichhart, P. Meier, and N. Silverman. 2010. Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-κB signaling. Mol. Cell 37: 172-182.
68. Feoktistova, M., P. Geserick, B. Kellert, D. P. Dimitrova, C. Langlais, M. Hupe, K. Cain, M. MacFarlane, G. Häcker, and M. Leverkus. 2011. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43: 449-463.
69. Tenev, T., K. Bianchi, M. Darding, M. Broemer, C. Langlais, F. Wallberg, A. Zachariou, J. Lopez, M. MacFarlane, K. Cain, and P. Meier. 2011. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 43: 432-448.
70. Vince, J. E., W. W.-L. Wong, I. Gentle, K. E. Lawlor, R. Allam, L. O'Reilly, K. Mason, O. Gross, S. Ma, G. Guarda, et al. 2012. Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Immunity 36: 215-227.
71. Kang, T.-B., S.-H. Yang, B. Toth, A. Kovalenko, and D. Wallach. 2012. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 38: 27-40.
72. Wu, Y.-H., W.-C. Kuo, Y.-J. Wu, K.-T. Yang, S.-T. Chen, S.-T. Jiang, C. Gordy, Y.-W. He, and M.-Z. Lai. 2013. Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation. Cell Death Differ. 21: 451-461.
73. Bromuro, C., M. Romano, P. Chiani, F. Berti, M. Tontini, D. Proietti, E. Mori, A. Torosantucci, P. Costantino, R. Rappuoli, and A. Cassone. 2010. β-glucan-CRM197 conjugates as candidates antifungal vaccines. Vaccine 28: 2615-2623.
74. Torosantucci, A., C. Bromuro, P. Chiani, F. De Bernardis, F. Berti, C. Galli, F. Norelli, C. Bellucci, L. Polonelli, P. Costantino, et al. 2005. A novel glycoconjugate vaccine against fungal pathogens. J. Exp. Med. 202: 597-606.
75. Aleem, E. 2013. β-Glucans and their applications in cancer therapy: focus on human studies. Anticancer. Agents Med. Chem. 13: 709-719.
76. Chan, G. C., W. K. Chan, and D. M. Sze. 2009. The effects of β-glucan on human immune and cancer cells. J Hematol Oncol 2: 25.
77. Soto, E. R., A. C. Caras, L. C. Kut, M. K. Castle, and G. R. Ostroff. 2012. Glucan particles for macrophage targeted delivery of nanoparticles. J. Drug Deliv. 2012: 143524.
78. LeibundGut-Landmann, S., O. Gross, M. J. Robinson, F. Osorio, E. C. Slack, S. V. Tsoni, E. Schweighoffer, V. Tybulewicz, G. D. Brown, J. Ruland, and C. Reis e Sousa. 2007. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8: 630-638.