Colonic transit time and IBS symptoms: What's the link?

American Journal of Gastroenterology

Volumn 107, Issue 5, 2012, Pages 754-760

  Törnblom, Hans ^a,b,c   Van Oudenhove, Lukas ^d   Sadik, Riadh ^a   Abrahamsson, Hasse ^a   Tack, Jan ^d   Simrén, Magnus ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOATING; BRISTOL STOOL FORM SCALE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FECES ANALYSIS; FEMALE; FLATULENCE; GASTROINTESTINAL SYMPTOM; HUMAN; INTESTINE TRANSIT TIME; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; ROME II MODULAR QUESTIONNAIRE; ROME III QUESTIONNAIRE; SEX DIFFERENCE; ADOLESCENT; COLON; DEFECATION; GASTROINTESTINAL TRANSIT; MIDDLE AGED; PATHOPHYSIOLOGY;

ADOLESCENT; ADULT; AGED; COLON; DEFECATION; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; QUESTIONNAIRES; YOUNG ADULT;

EID: 84862333026     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2012.5     Document Type: Article

References (38)

1. Agreus L, Svardsudd K, Nyren O et al. Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology 1995;109:671-80.
2. Drossman DA, Li Z, Andruzzi E et al. US householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci 1993;38:1569-80. (Pubitemid 23271409)
3. Gwee KA. Irritable bowel syndrome in developing countries - a disorder of civilization or colonization? Neurogastroenterol Motil 2005;17:317-24.
4. Hungin AP, Chang L, Locke GR et al. Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment Pharmacol Ther 2005;21:1365-75. (Pubitemid 40813683)
5. Lau EM, Chan FK, Ziea ET et al. Epidemiology of irritable bowel syndrome in Chinese. Dig Dis Sci 2002;47:2621-4. (Pubitemid 35305476)
6. Longstreth GF, Bolus R, Naliboff B et al. Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trials. Eur J Gastroenterol Hepatol 2005;17:411-20. (Pubitemid 40477510)
7. Dhaliwal SK, Hunt RH. Doctor-patient interaction for irritable bowel syndrome in primary care: a systematic perspective. Eur J Gastroenterol Hepatol 2004;16:1161-6. (Pubitemid 39488788)
8. Inadomi JM, Fennerty MB, Bjorkman D. Systematic review: the economic impact of irritable bowel syndrome. Aliment Pharmacol Ther 2003;18:671-82. (Pubitemid 37271832)
9. Spiller R, Aziz Q, Creed F et al. Guidelines on the irritable bowel syndrome: mechanisms and practical management. Gut 2007;56:1770-98. (Pubitemid 350206308)
10. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130:1377-90.
11. Longstreth GF, Th ompson WG, Chey WD et al. Functional bowel disorders. Gastroenterology 2006;130:1480-91.
12. O'Donnell LJ, Virjee J, Heaton KW. Detection of pseudodiarrhoea by simple clinical assessment of intestinal transit rate. BMJ 1990;300:439-40. (Pubitemid 20069266)
13. Degen LP, Phillips SF. How well does stool form reflect colonic transit? Gut 1996;39:109-13. (Pubitemid 26239116)
14. Saad RJ, Rao SS, Koch KL et al. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol 2010;105:403-11.
15. Chaussade S, Khyari A, Roche H et al. Determination of total and segmental colonic transit time in constipated patients. Results in 91 patients with a new simplified method. Dig Dis Sci 1989;34:1168-72. (Pubitemid 19202109)
16. Glia A, Lindberg G, Nilsson LH et al. Clinical value of symptom assessment in patients with constipation. Dis Colon Rectum 1999;42:1401-8; discussion 1408-10.
17. Sadik R, Bjornsson E, Simren M. The relationship between symptoms, body mass index, gastrointestinal transit and stool frequency in patients with irritable bowel syndrome. Eur J Gastroenterol Hepatol 2010;22:102-8.
18. Manabe N, Wong BS, Camilleri M et al. Lower functional gastrointestinal disorders: evidence of abnormal colonic transit in a 287 patient cohort. Neurogastroenterol Motil 2010;22:293-e82.
19. Rao SS, Camilleri M, Hasler WL et al. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil 2011;23:8-23.
20. Graff J, Brinch K, Madsen JL. Simplified scintigraphic methods for measuring gastrointestinal transit times. Clin Physiol 2000;20:262-6. (Pubitemid 30456123)
21. Th ompson WG, Longstreth GF, Drossman DA et al. Functional bowel disorders and functional abdominal pain. Gut 1999;45 (Suppl 2):II43-7.
22. Sadik R, Abrahamsson H, Stotzer PO. Gender diff erences in gut transit shown with a newly developed radiological procedure. Scand J Gastroenterol 2003;38:36-42. (Pubitemid 36152862)
23. Sadik R, Abrahamsson H, Ung KA et al. Accelerated regional bowel transit and overweight shown in idiopathic bile acid malabsorption. Am J Gastroenterol 2004;99:711-8. (Pubitemid 38607976)
24. Sadik R, Stotzer PO, Simren M et al. Gastrointestinal transit abnormalities are frequently detected in patients with unexplained GI symptoms at a tertiary centre. Neurogastroenterol Motil 2008;20:197-205. (Pubitemid 351197397)
25. Abrahamsson H, Antov S, Bosaeus I. Gastrointestinal and colonic segmental transit time evaluated by a single abdominal X-ray in healthy subjects and constipated patients. Scand J Gastroenterol Suppl 1988;152:72-80. (Pubitemid 19050865)
26. Drossman DA, Talley NJ, Th ompson WG (ed). Research Diagnostic Questions for Functional Gastrointestinal Disorders: Rome II Modular Questionnaire: Investigations and Respondent Forms, 2nd ed McLean, VA: Degnon Associates, 2000.
27. Abrahamsson H, Antov S. Accuracy in assessment of colonic transit time with particles: how many markers should be used? Neurogastroenterol Motil 2010;22:1164-9.
28. Sarnelli G, Caenepeel P, Geypens B et al. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003;98:783-8. (Pubitemid 36576302)
29. Tack J, Caenepeel P, Fischler B et al. Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 2001;121:526-35. (Pubitemid 32822566)
30. Tack J, Piessevaux H, Coulie B et al. Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 1998;115:1346-52. (Pubitemid 28545984)
31. Guilera M, Balboa A, Mearin F. Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. Am J Gastroenterol 2005;100:1174-84. (Pubitemid 40769059)
32. Bouchoucha M, Devroede G, Dorval E et al. Diff erent segmental transit times in patients with irritable bowel syndrome and 'normal' colonic transit time: is there a correlation with symptoms? Tech Coloproctol 2006;10:287-96.
33. Cann PA, Read NW, Brown C et al. Irritable bowel syndrome: relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 1983;24:405-11. (Pubitemid 13089484)
34. Posserud I, Syrous A, Lindstrom L et al. Altered rectal perception in irritable bowel syndrome is associated with symptom severity. Gastroentero logy 2007;133:1113-23. (Pubitemid 47494459)
35. Mayer EA, Tillisch K. The brain-gut axis in abdominal pain syndromes. Annu Rev Med 2011;62:381-96.
36. Ragnarsson G, Bodemar G. Pain is temporally related to eating but not to defaecation in the irritable bowel syndrome (IBS). Patients' description of diarrhea, constipation and symptom variation during a prospective 6-week study. Eur J Gastroenterol Hepatol 1998;10:415-21. (Pubitemid 28241429)
37. Evans BW, Clark WK, Moore DJ et al. Tegaserod for the treatment of irritable bowel syndrome and chronic constipation. Cochrane Database Syst Rev 2007;CD003960.
38. Drossman DA, Morris CB, Hu Y et al. A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology 2005;128:580-9. (Pubitemid 40585359)