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Volumn 24, Issue 12, 2012, Pages

Colonic mucosal mediators from patients with irritable bowel syndrome excite enteric cholinergic motor neurons

Author keywords

Enteric nervous system; Inflammatory mucosal mediators; Irritable bowel syndrome; Mast cells; Twitch contractions

Indexed keywords

3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; CAPSAZEPINE; HISTAMINE H1 RECEPTOR; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SERINE PROTEINASE; SEROTONIN 1 RECEPTOR; SEROTONIN 4 RECEPTOR;

EID: 84870300639     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.12000     Document Type: Article
Times cited : (60)

References (50)
  • 3
    • 0036177386 scopus 로고    scopus 로고
    • Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors
    • Simren M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J, Bjornsson ES. Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors. Am J Gastroenterol 2002; 97: 389-96.
    • (2002) Am J Gastroenterol , vol.97 , pp. 389-396
    • Simren, M.1    Axelsson, J.2    Gillberg, R.3    Abrahamsson, H.4    Svedlund, J.5    Bjornsson, E.S.6
  • 4
    • 65449165950 scopus 로고    scopus 로고
    • Postinfectious irritable bowel syndrome
    • Spiller R, Garsed K. Postinfectious irritable bowel syndrome. Gastroenterology 2009; 136: 1979-88.
    • (2009) Gastroenterology , vol.136 , pp. 1979-1988
    • Spiller, R.1    Garsed, K.2
  • 5
    • 10744225624 scopus 로고    scopus 로고
    • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    • Barbara G, Stanghellini V, De Giorgio R et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702.
    • (2004) Gastroenterology , vol.126 , pp. 693-702
    • Barbara, G.1    Stanghellini, V.2    De Giorgio, R.3
  • 7
    • 33846989359 scopus 로고    scopus 로고
    • Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    • Guilarte M, Santos J, de Torres I et al. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 2007; 56: 203-9.
    • (2007) Gut , vol.56 , pp. 203-209
    • Guilarte, M.1    Santos, J.2    de Torres, I.3
  • 9
    • 33847342529 scopus 로고    scopus 로고
    • Role for protease activity in visceral pain in irritable bowel syndrome
    • Cenac N, Andrews CN, Holzhausen M et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007; 117: 636-47.
    • (2007) J Clin Invest , vol.117 , pp. 636-647
    • Cenac, N.1    Andrews, C.N.2    Holzhausen, M.3
  • 10
    • 33846193703 scopus 로고    scopus 로고
    • Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    • Barbara G, Wang B, Stanghellini V et al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007; 132: 26-37.
    • (2007) Gastroenterology , vol.132 , pp. 26-37
    • Barbara, G.1    Wang, B.2    Stanghellini, V.3
  • 11
    • 70349423402 scopus 로고    scopus 로고
    • Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    • Buhner S, Li Q, Vignali S et al. Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 2009; 137: 1425-34.
    • (2009) Gastroenterology , vol.137 , pp. 1425-1434
    • Buhner, S.1    Li, Q.2    Vignali, S.3
  • 12
    • 77956102855 scopus 로고    scopus 로고
    • The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
    • Klooker TK, Braak B, Koopman KE et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 2010; 59: 1213-21.
    • (2010) Gut , vol.59 , pp. 1213-1221
    • Klooker, T.K.1    Braak, B.2    Koopman, K.E.3
  • 13
    • 84856720903 scopus 로고    scopus 로고
    • Serum and colonic mucosal immune markers in irritable bowel syndrome
    • Chang L, Adeyemo M, Karagiannides I et al. Serum and colonic mucosal immune markers in irritable bowel syndrome. Am J Gastroenterol 2012; 107: 262-72.
    • (2012) Am J Gastroenterol , vol.107 , pp. 262-272
    • Chang, L.1    Adeyemo, M.2    Karagiannides, I.3
  • 14
    • 79958134222 scopus 로고    scopus 로고
    • Colonic mast cells in controls and slow transit constipation patients
    • Bassotti G, Villanacci V, Nascimbeni R et al. Colonic mast cells in controls and slow transit constipation patients. Aliment Pharmacol Ther 2011; 34: 92-9.
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 92-99
    • Bassotti, G.1    Villanacci, V.2    Nascimbeni, R.3
  • 15
    • 68849099107 scopus 로고    scopus 로고
    • Neuroimmune mechanisms in postoperative ileus
    • Boeckxstaens GE, de Jonge WJ. Neuroimmune mechanisms in postoperative ileus. Gut 2009; 58: 1300-11.
    • (2009) Gut , vol.58 , pp. 1300-1311
    • Boeckxstaens, G.E.1    de Jonge, W.J.2
  • 18
    • 0014243523 scopus 로고
    • The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips
    • Paton WD, Zar MA. The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips. J Physiol 1968; 194: 13-33.
    • (1968) J Physiol , vol.194 , pp. 13-33
    • Paton, W.D.1    Zar, M.A.2
  • 19
    • 0034012172 scopus 로고    scopus 로고
    • Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids
    • Sharif NA, Crider JY, Xu SX, Williams GW. Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids. J Pharmacol Exp Ther 2000; 293: 321-8.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 321-328
    • Sharif, N.A.1    Crider, J.Y.2    Xu, S.X.3    Williams, G.W.4
  • 20
    • 0029941771 scopus 로고    scopus 로고
    • Effects of BW A868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations
    • Liu YJ, Jackson DM, Blackham A. Effects of BW A868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations. Eur J Pharmacol 1996; 303: 187-92.
    • (1996) Eur J Pharmacol , vol.303 , pp. 187-192
    • Liu, Y.J.1    Jackson, D.M.2    Blackham, A.3
  • 22
    • 19544392708 scopus 로고    scopus 로고
    • Clinical relevance of proteinase activated receptors (pars) in the gut
    • Vergnolle N. Clinical relevance of proteinase activated receptors (pars) in the gut. Gut 2005; 54: 867-74.
    • (2005) Gut , vol.54 , pp. 867-874
    • Vergnolle, N.1
  • 23
    • 84867026762 scopus 로고    scopus 로고
    • Bacterial proteases in IBD and IBS
    • doi: 10.1136/gutjnl-2011-300775.
    • Steck N, Mueller K, Schemann M, Haller D. Bacterial proteases in IBD and IBS. Gut 2011; doi: 10.1136/gutjnl-2011-300775.
    • (2011) Gut
    • Steck, N.1    Mueller, K.2    Schemann, M.3    Haller, D.4
  • 24
    • 34248576759 scopus 로고    scopus 로고
    • Physiology and pathophysiology of purinergic neurotransmission
    • Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev 2007; 87: 659-797.
    • (2007) Physiol Rev , vol.87 , pp. 659-797
    • Burnstock, G.1
  • 26
    • 0035253835 scopus 로고    scopus 로고
    • Nucleotide receptors: an emerging family of regulatory molecules in blood cells
    • Di Virgilio F, Chiozzi P, Ferrari D et al. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood 2001; 97: 587-600.
    • (2001) Blood , vol.97 , pp. 587-600
    • Di Virgilio, F.1    Chiozzi, P.2    Ferrari, D.3
  • 27
    • 70350347701 scopus 로고    scopus 로고
    • Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells
    • Wareham K, Vial C, Wykes RC, Bradding P, Seward EP. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. Br J Pharmacol 2009; 157: 1215-24.
    • (2009) Br J Pharmacol , vol.157 , pp. 1215-1224
    • Wareham, K.1    Vial, C.2    Wykes, R.C.3    Bradding, P.4    Seward, E.P.5
  • 28
    • 0036904032 scopus 로고    scopus 로고
    • Neuroimmune and epithelial interactions in intestinal inflammation
    • Sharkey KA, Mawe GM. Neuroimmune and epithelial interactions in intestinal inflammation. Curr Opin Pharmacol 2002; 2: 669-77.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 669-677
    • Sharkey, K.A.1    Mawe, G.M.2
  • 29
    • 67650590969 scopus 로고    scopus 로고
    • Purinergic receptors and pain
    • Burnstock G. Purinergic receptors and pain. Curr Pharm Des 2009; 15: 1717-35.
    • (2009) Curr Pharm Des , vol.15 , pp. 1717-1735
    • Burnstock, G.1
  • 30
    • 65949110375 scopus 로고    scopus 로고
    • Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease
    • Rong W, Keating C, Sun B, Dong L, Grundy D. Purinergic contribution to small intestinal afferent hypersensitivity in a murine model of postinfectious bowel disease. Neurogastroenterol Motil 2009; 21: 665-71.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 665-671
    • Rong, W.1    Keating, C.2    Sun, B.3    Dong, L.4    Grundy, D.5
  • 31
    • 2342563746 scopus 로고    scopus 로고
    • ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum
    • Monro RL, Bertrand PP, Bornstein JC. ATP participates in three excitatory postsynaptic potentials in the submucous plexus of the guinea pig ileum. J Physiol 2004; 556: 571-84.
    • (2004) J Physiol , vol.556 , pp. 571-584
    • Monro, R.L.1    Bertrand, P.P.2    Bornstein, J.C.3
  • 32
    • 0037096301 scopus 로고    scopus 로고
    • ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors
    • Bertrand PP, Bornstein JC. ATP as a putative sensory mediator: activation of intrinsic sensory neurons of the myenteric plexus via P2X receptors. J Neurosci 2002; 22: 4767-75.
    • (2002) J Neurosci , vol.22 , pp. 4767-4775
    • Bertrand, P.P.1    Bornstein, J.C.2
  • 33
    • 2442608827 scopus 로고    scopus 로고
    • Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function
    • Geppetti P, Trevisani M. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol 2004; 141: 1313-20.
    • (2004) Br J Pharmacol , vol.141 , pp. 1313-1320
    • Geppetti, P.1    Trevisani, M.2
  • 34
    • 46349106355 scopus 로고    scopus 로고
    • Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
    • Akbar A, Yiangou Y, Facer P, Walters JR, Anand P, Ghosh S. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 2008; 57: 923-9.
    • (2008) Gut , vol.57 , pp. 923-929
    • Akbar, A.1    Yiangou, Y.2    Facer, P.3    Walters, J.R.4    Anand, P.5    Ghosh, S.6
  • 35
    • 0041691167 scopus 로고    scopus 로고
    • Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
    • Ward SM, Bayguinov J, Won KJ, Grundy D, Berthoud HR. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol 2003; 465: 121-35.
    • (2003) J Comp Neurol , vol.465 , pp. 121-135
    • Ward, S.M.1    Bayguinov, J.2    Won, K.J.3    Grundy, D.4    Berthoud, H.R.5
  • 36
    • 20844446302 scopus 로고    scopus 로고
    • Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification
    • Bartho L, Benko R, Patacchini R et al. Effects of capsaicin on visceral smooth muscle: a valuable tool for sensory neurotransmitter identification. Eur J Pharmacol 2004; 500: 143-57.
    • (2004) Eur J Pharmacol , vol.500 , pp. 143-157
    • Bartho, L.1    Benko, R.2    Patacchini, R.3
  • 37
    • 31044456535 scopus 로고    scopus 로고
    • Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine
    • Geber C, Mang CF, Kilbinger H. Facilitation and inhibition by capsaicin of cholinergic neurotransmission in the guinea-pig small intestine. Naunyn Schmiedebergs Arch Pharmacol 2006; 372: 277-83.
    • (2006) Naunyn Schmiedebergs Arch Pharmacol , vol.372 , pp. 277-283
    • Geber, C.1    Mang, C.F.2    Kilbinger, H.3
  • 38
    • 0020335145 scopus 로고
    • Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P
    • Bartho L, Holzer P, Lembeck F, Szolcsanyi J. Evidence that the contractile response of the guinea-pig ileum to capsaicin is due to release of substance P. J Physiol 1982; 332: 157-67.
    • (1982) J Physiol , vol.332 , pp. 157-167
    • Bartho, L.1    Holzer, P.2    Lembeck, F.3    Szolcsanyi, J.4
  • 39
    • 4143069154 scopus 로고    scopus 로고
    • Enteric neuroimmunophysiology and pathophysiology
    • Wood JD. Enteric neuroimmunophysiology and pathophysiology. Gastroenterology 2004; 127: 635-57.
    • (2004) Gastroenterology , vol.127 , pp. 635-657
    • Wood, J.D.1
  • 40
    • 0030795009 scopus 로고    scopus 로고
    • Effects of the inflammatory mediator prostaglandin E2 on myenteric neurons in guinea pig ileum
    • Dekkers JA, Akkermans LM, Kroese AB. Effects of the inflammatory mediator prostaglandin E2 on myenteric neurons in guinea pig ileum. Am J Physiol 1997; 272: G1451-6.
    • (1997) Am J Physiol , vol.272
    • Dekkers, J.A.1    Akkermans, L.M.2    Kroese, A.B.3
  • 41
    • 0028011924 scopus 로고
    • Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon
    • Frieling T, Rupprecht C, Kroese AB, Schemann M. Effects of the inflammatory mediator prostaglandin D2 on submucosal neurons and secretion in guinea pig colon. Am J Physiol 1994; 266: G132-9.
    • (1994) Am J Physiol , vol.266
    • Frieling, T.1    Rupprecht, C.2    Kroese, A.B.3    Schemann, M.4
  • 42
    • 47649118832 scopus 로고    scopus 로고
    • Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients
    • Kerckhoffs AP, Ter Linde JJ, Akkermans LM, Samsom M. Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients. Neurogastroenterol Motil 2008; 20: 900-7.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 900-907
    • Kerckhoffs, A.P.1    Ter Linde, J.J.2    Akkermans, L.M.3    Samsom, M.4
  • 43
    • 84871491452 scopus 로고    scopus 로고
    • Submucous rather than myenteric neurons are activated by supernatants of mucosal biopsies from IBS patients
    • Buhner S, Li Q, Berger T et al. Submucous rather than myenteric neurons are activated by supernatants of mucosal biopsies from IBS patients. Neurogastroenterol Motil 2010; 22: 1.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 1
    • Buhner, S.1    Li, Q.2    Berger, T.3
  • 44
    • 59749085184 scopus 로고    scopus 로고
    • Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms
    • Cremon C, Gargano L, Morselli-Labate AM et al. Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol 2009; 104: 392-400.
    • (2009) Am J Gastroenterol , vol.104 , pp. 392-400
    • Cremon, C.1    Gargano, L.2    Morselli-Labate, A.M.3
  • 45
    • 0023931794 scopus 로고
    • Symptoms and stool patterns in patients with ulcerative colitis
    • Rao SS, Holdsworth CD, Read NW. Symptoms and stool patterns in patients with ulcerative colitis. Gut 1988; 29: 342-5.
    • (1988) Gut , vol.29 , pp. 342-345
    • Rao, S.S.1    Holdsworth, C.D.2    Read, N.W.3
  • 47
    • 42249114703 scopus 로고    scopus 로고
    • Clinical practice. Irritable bowel syndrome
    • Mayer EA. Clinical practice. Irritable bowel syndrome. N Engl J Med 2008; 358: 1692-9.
    • (2008) N Engl J Med , vol.358 , pp. 1692-1699
    • Mayer, E.A.1
  • 48
    • 77950825420 scopus 로고    scopus 로고
    • Aminosalicylates and other anti-inflammatory compounds for irritable bowel syndrome
    • Barbara G, Stanghellini V, Cremon C et al. Aminosalicylates and other anti-inflammatory compounds for irritable bowel syndrome. Dig Dis 2009; 27(Suppl. 1): 115-21.
    • (2009) Dig Dis , vol.27 , Issue.SUPPL. 1 , pp. 115-121
    • Barbara, G.1    Stanghellini, V.2    Cremon, C.3
  • 49
    • 67650523807 scopus 로고    scopus 로고
    • Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study
    • Corinaldesi R, Stanghellini V, Cremon C et al. Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study. Aliment Pharmacol Ther 2009; 30: 245-52.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 245-252
    • Corinaldesi, R.1    Stanghellini, V.2    Cremon, C.3
  • 50
    • 6944241305 scopus 로고    scopus 로고
    • Age-related decline in rectal mucosal lymphocytes and mast cells
    • Dunlop SP, Jenkins D, Spiller RC. Age-related decline in rectal mucosal lymphocytes and mast cells. Eur J Gastroenterol Hepatol 2004; 16: 1011-5.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 1011-1015
    • Dunlop, S.P.1    Jenkins, D.2    Spiller, R.C.3


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