Imbalanced shift of cytokine expression between T helper 1 and T helper 2 (Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel syndrome

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Chen, Ji ^a,b   Zhang, Yangde ^a   Deng, Zhansheng ^c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b INNER MONGOLIA MEDICAL COLLEGE   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cytokine; Intestinal mucosa; Irritable bowel syndrome; Th1 Th2

Indexed keywords

BETA ACTIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA;

ADULT; ARTICLE; ASCENDING COLON; CELL FUNCTION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DESCENDING COLON; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INTESTINE MUCOSA; IRRITABLE COLON; MALE; POSTINFECTIOUS IRRITABLE BOWEL SYNDROME; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECTUM MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH1 TH2 BALANCE; TH2 CELL; TREND STUDY; UPREGULATION; WESTERN BLOTTING;

ADULT; CASE-CONTROL STUDIES; COLON; CYTOKINES; FEMALE; HUMANS; IMMUNE SYSTEM; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; INTESTINAL DISEASES; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; RNA, MESSENGER; TH1 CELLS; TH2 CELLS;

EID: 84866182203     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-91     Document Type: Article

References (20)

1. Lee HF, Hsieh JC, Lu CL, Yeh TC, Tu CH, Cheng CM, Niddam DM, Lin HC, Lee FY, Chang FY. Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients. Pain 2012, 153:1301-1310. 10.1016/j.pain.2012.03.018, 22541443.
2. Spiller R, Garsed K. Postinfectious irritable bowel syndrome. Gastroenterology 2009, 136:1979-1988. 10.1053/j.gastro.2009.02.074, 19457422.
3. Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet 2007, 369:1627-1640. 10.1016/S0140-6736(07)60750-8, 17499605.
4. Elsenbruch S. Abdominal pain in Irritable Bowel Syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun 2011, 25:386-394. 10.1016/j.bbi.2010.11.010, 21094682.
5. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006, 130:1480-1491. 10.1053/j.gastro.2005.11.061, 16678561.
6. Cremon C, Gargano L, Morselli-Labate AM, Santini D, Cogliandro RF, De Giorgio R, Stanghellini V, Corinaldesi R, Barbara G. Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol 2009, 104:392-400. 10.1038/ajg.2008.94, 19174797.
7. Coffin B. Diagnosis of irritable bowel syndrome. Gastroenterol Clin Biol 2009, 33(Suppl 1):S9-S16.
8. Corinaldesi R, Stanghellini V, Cremon C, Gargano L, Cogliandro RF, De Giorgio R, Bartesaghi G, Canovi B, Barbara G. Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study. Aliment Pharmacol Ther 2009, 30:245-252. 10.1111/j.1365-2036.2009.04041.x, 19438846.
9. Feng B, La JH, Schwartz ES, Gebhart GF. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2012, 302:G1085-G1098. 10.1152/ajpgi.00542.2011, 22403791.
10. Ludigs K, Parfenov V, Du Pasquier RA, Guarda G. Type I IFN-mediated regulation of IL-1 production in inflammatory disorders. Cell Mol Life Sci 2012,
11. Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 2009, 10:1178-1184. 10.1038/ni.1791, 2898179, 19783988.
12. De Winter BY, van den Wijngaard RM, de Jonge WJ. Intestinal mast cells in gut inflammation and motility disturbances. Biochim Biophys Acta 2012, 1822:66-73. 10.1016/j.bbadis.2011.03.016, 21497195.
13. Bercik P, Wang L, Verdu EF, Mao YK, Blennerhassett P, Khan WI, Kean I, Tougas G, Collins SM. Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction. Gastroenterology 2004, 127:179-187. 10.1053/j.gastro.2004.04.006, 15236184.
14. Gwee KA. Post-Infectious Irritable Bowel Syndrome, an Inflammation-Immunological Model with Relevance for Other IBS and Functional Dyspepsia. J Neurogastroenterol Motil 2010, 16:30-34. 10.5056/jnm.2010.16.1.30, 2879823, 20535323.
15. Gomes-Santos AC, Moreira TG, Castro-Junior AB, Horta BC, Lemos L, Cruz DN, Guimaraes MA, Cara DC, McCafferty DM, Faria AM. New insights into the immunological changes in IL-10-deficient mice during the course of spontaneous inflammation in the gut mucosa. Clin Dev Immunol 2012, 2012:560817. 3287045, 22400037.
16. Feng T, Qin H, Wang L, Benveniste EN, Elson CO, Cong Y. Th17 cells induce colitis and promote Th1 cell responses through IL-17 induction of innate IL-12 and IL-23 production. J Immunol 2011, 186:6313-6318. 10.4049/jimmunol.1001454, 3249225, 21531892.
17. Dinan TG, Quigley EM, Ahmed SM, Scully P, O'Brien S, O'Mahony L, O'Mahony S, Shanahan F, Keeling PW. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?. Gastroenterology 2006, 130:304-311. 10.1053/j.gastro.2005.11.033, 16472586.
18. Mizutani T, Akiho H, Khan WI, Murao H, Ogino H, Kanayama K, Nakamura K, Takayanagi R. Persistent gut motor dysfunction in a murine model of T-cell-induced enteropathy. Neurogastroenterol Motil 2010, 22:196-203. e165, 10.1111/j.1365-2982.2009.01396.x, 19735478.
19. Bellini M, Rappelli L, Blandizzi C, Costa F, Stasi C, Colucci R, Giannaccini G, Marazziti D, Betti L, Baroni S, et al. Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron. Am J Gastroenterol 2003, 98:2705-2711. 10.1111/j.1572-0241.2003.08669.x, 14687821.
20. Roka R, Rosztoczy A, Leveque M, Izbeki F, Nagy F, Molnar T, Lonovics J, Garcia-Villar R, Fioramonti J, Wittmann T, et al. A pilot study of fecal serine-protease activity: a pathophysiologic factor in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007, 5:550-555. 10.1016/j.cgh.2006.12.004, 17336590.