Role of toll like receptors in irritable bowel syndrome: Differential mucosal immune activation according to the disease subtype

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Belmonte, Liliana ^a,b,c   Beutheu Youmba, Stéphanie ^a,b   Bertiaux Vandaële, Nathalie ^d   Antonietti, Michel ^d   Lecleire, Stéphane ^a,b,d   Zalar, Alberto ^d   Gourcerol, Guillaume ^a,b,d   Leroi, Anne Marie ^a,b,d   Déchelotte, Pierre ^a,b,d   Coëffier, Moïse ^a,b,d   Ducrotté, Philippe ^a,b,d  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITY OF ROUEN   (France)

^c INST DE INVEST HEMATOLOGICAS   (Argentina)

^d ROUEN UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; COLON MUCOSA; CONSTIPATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOSTIMULATION; INFLAMMATION; INNATE IMMUNITY; INTESTINE EPITHELIUM CELL; IRRITABLE COLON; MALE; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ADULT; AGED; ANTIGENS, CD14; CASE-CONTROL STUDIES; COLON; CYTOKINES; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; PPAR GAMMA; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84865066764     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042777     Document Type: Article

References (32)

1. Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, et al. (1999) Functional bowel disorders and functional abdominal pain. Gut 45 (Suppl 2): II43-47.
2. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, et al. (2006) Functional bowel disorders. Gastroenterology 130: 1480-1491.
3. Ohman L, Isaksson S, Lindmark AC, Posserud I, Stotzer PO, et al. (2009) T-cell activation in patients with irritable bowel syndrome. Am J Gastroenterol 104: 1205-1212.
4. Cremon C, Gargano L, Morselli-Labate AM, Santini D, Cogliandro RF, et al. (2009) Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol 104: 392-400.
5. Barbara G, De Giorgio R, Stanghellini V, Cremon C, Corinaldesi R, (2002) A role for inflammation in irritable bowel syndrome? Gut 51 (Suppl 1): i41-44.
6. Kassinen A, Krogius-Kurikka L, Makivuokko H, Rinttila T, Paulin L, et al. (2007) The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology 133: 24-33.
7. Camilleri M, Gorman H, (2007) Intestinal permeability and irritable bowel syndrome. Neurogastroenterol Motil 19: 545-552.
8. Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, et al. (2006) Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 101: 1288-1294.
9. Srikanth CV, McCormick BA, (2008) Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk. Interdiscip Perspect Infect Dis 2008: 626827.
10. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451.
11. Medzhitov R, (2001) Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145.
12. Takeda K, Kaisho T, Akira S, (2003) Toll-like receptors. Annu Rev Immunol 21: 335-376.
13. Gribar SC, Richardson WM, Sodhi CP, Hackam DJ, (2008) No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med 14: 645-659.
14. Lien E, Sellati TJ, Yoshimura A, Flo TH, Rawadi G, et al. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 274: 33419-33425.
15. Kawai T, Akira S, (2006) TLR signaling. Cell Death Differ 13: 816-825.
16. Podolsky DK, (2002) Inflammatory bowel disease. N Engl J Med 347: 417-429.
17. Hausmann M, Kiessling S, Mestermann S, Webb G, Spottl T, et al. (2002) Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122: 1987-2000.
18. Cario E, Podolsky DK, (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68: 7010-7017.
19. Szebeni B, Veres G, Dezsofi A, Rusai K, Vannay A, et al. (2007) Increased mucosal expression of Toll-like receptor (TLR)2 and TLR4 in coeliac disease. J Pediatr Gastroenterol Nutr 45: 187-193.
20. Shibolet O, Podolsky DK, (2007) TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. Am J Physiol Gastrointest Liver Physiol 292: G1469-1473.
21. Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, et al. (1999) A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 104: 383-389.
22. Dubuquoy L, Jansson EA, Deeb S, Rakotobe S, Karoui M, et al. (2003) Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 124: 1265-1276.
23. Coeffier M, Claeyssens S, Hecketsweiler B, Lavoinne A, Ducrotte P, et al. (2003) Enteral glutamine stimulates protein synthesis and decreases ubiquitin mRNA level in human gut mucosa. Am J Physiol Gastrointest Liver Physiol 285: G266-273.
24. Zalar A, Figueroa MI, Ruibal-Ares B, Bare P, Cahn P, et al. (2010) Macrophage HIV-1 infection in duodenal tissue of patients on long term HAART. Antiviral Res 87: 269-271.
25. Lecleire S, Hassan A, Marion-Letellier R, Antonietti M, Savoye G, et al. (2008) Combined glutamine and arginine decrease proinflammatory cytokine production by biopsies from Crohn's patients in association with changes in nuclear factor-kappaB and p38 mitogen-activated protein kinase pathways. J Nutr 138: 2481-2486.
26. Frolova L, Drastich P, Rossmann P, Klimesova K, Tlaskalova-Hogenova H, (2008) Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem 56: 267-274.
27. Brint EK, MacSharry J, Fanning A, Shanahan F, Quigley EM, (2010) Differential expression of toll-like receptors in patients with irritable bowel syndrome. Am J Gastroenterol 106: 329-336.
28. McKernan DP, Gaszner G, Quigley EM, Cryan JF, Dinan TG, (2011) Altered peripheral toll-like receptor responses in the irritable bowel syndrome. Aliment Pharmacol Ther 33: 1045-1052.
29. Sato S, Nomura F, Kawai T, Takeuchi O, Muhlradt PF, et al. (2000) Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J Immunol 165: 7096-7101.
30. Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, et al. (1995) A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95: 55-65.
31. Drossman DA, Morris CB, Hu Y, Toner BB, Diamant N, et al. (2005) A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology 128: 580-589.
32. O'Hara AM, Shanahan F, (2006) The gut flora as a forgotten organ. EMBO Rep 7: 688-693.