Immune Activation in Patients With Irritable Bowel Syndrome

Gastroenterology

Volumn 132, Issue 3, 2007, Pages 913-920

  Liebregts, Tobias ^a,b   Adam, Birgit ^a,b   Bredack, Christoph ^a,b   Röth, Alexander ^c   Heinzel, Susanne ^a   Lester, Sue ^b   Downie Doyle, Sarah ^b   Smith, Eric ^a   Drew, Paul ^a   Talley, Nicholas J ^d,e   Holtmann, Gerald ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b HANSON INSTITUTE   (Australia)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d MAYO CLINIC   (United States)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANXIETY; ARTICLE; CELL CULTURE; CELL ISOLATION; COMORBIDITY; CONSTIPATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENSITY GRADIENT CENTRIFUGATION; DIARRHEA; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; PAINFUL DEFECATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; QUESTIONNAIRE; RATING SCALE; STATISTICAL SIGNIFICANCE; SYMPTOM; VERNER MORRISON SYNDROME;

EID: 33947324517     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.01.046     Document Type: Article

References (48)

1. Talley N.J., and Spiller R. Irritable bowel syndrome: a little understood organic bowel disease?. Lancet 360 (2002) 555-564
2. McKendrick M.W., and Read N.W. Irritable bowel syndrome-post salmonella infection. J Infect 29 (1994) 1-3
3. Spiller R.C., Jenkins D., Thornley J.P., Hebden J.M., Wright T., Skinner M., and Neal K.R. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47 (2000) 804-811
4. Adam B., Liebregts T., Gschossmann J.M., Krippner C., Scholl F., Ruwe M., and Holtmann G. Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model. Pain 123 (2006) 179-186
5. van der Veek P.P., van den B.M., de Kroon Y.E., Verspaget H.W., and Masclee A.A. Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol 100 (2005) 2510-2516
6. Gonsalkorale W.M., Perrey C., Pravica V., Whorwell P.J., and Hutchinson I.V. Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?. Gut 52 (2003) 91-93
7. O'Mahony L., McCarthy J., Kelly P., Hurley G., Luo F., Chen K., O'Sullivan G.C., Kiely B., Collins J.K., Shanahan F., and Quigley E.M. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128 (2005) 541-551
8. Locke III G.R., Weaver A.L., Melton III L.J., and Talley N.J. Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case-control study. Am J Gastroenterol 99 (2004) 350-357
9. Gwee K.A., Graham J.C., McKendrick M.W., Collins S.M., Marshall J.S., Walters S.J., and Read N.W. Psychometric scores and persistence of irritable bowel after infectious diarrhoea. Lancet 347 (1996) 150-153
10. Simen B.B., Duman C.H., Simen A.A., and Duman R.S. TNFalpha signaling in depression and anxiety: behavioral consequences of individual receptor targeting. Biol Psychiatry 59 (2006) 775-785
11. Thompson W.G., Longstreth G.F., Drossman D.A., Heaton K.W., Irvine E.J., and Muller-Lissner S.A. Functional bowel disorders and functional abdominal pain. Gut 45 Suppl 2 (1999) II43-II47
12. Zigmond A.S., and Snaith R.P. The hospital anxiety and depression scale. Acta Psychiatr Scand 67 (1983) 361-370
13. Holtmann G., Liebregts T., and Siffert W. Molecular basis of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 18 (2004) 633-640
14. Liebregts T., Adam B., Bertel A., Jones S., Schulze J., Enders C., Sonnenborn U., Lackner K., and Holtmann G. Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model. Neurogastroenterol Motil 17 (2005) 410-414
15. Dinan T.G., Quigley E.M., Ahmed S.M., Scully P., O'Brien S., O'Mahony L., O'Mahony S., Shanahan F., and Keeling P.W. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?. Gastroenterology 130 (2006) 304-311
16. Seatter S.C., Li M.H., Bubrick M.P., and West M.A. Endotoxin pretreatment of human monocytes alters subsequent endotoxin-triggered release of inflammatory mediators. Shock 3 (1995) 252-258
17. Schattner A., Steinbock M., Tepper R., Schonfeld A., Vaisman N., and Hahn T. Tumour necrosis factor production and cell-mediated immunity in anorexia nervosa. Clin Exp Immunol 79 (1990) 62-66
18. Windle H.J., Ang Y.S., Athie-Morales V., McManus R., and Kelleher D. Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals. Gut 54 (2005) 25-32
19. Birkholz S., Knipp U., Nietzki C., Adamek R.J., and Opferkuch W. Immunological activity of lipopolysaccharide of Helicobacter pylori on human peripheral mononuclear blood cells in comparison to lipopolysaccharides of other intestinal bacteria. FEMS Immunol Med Microbiol 6 (1993) 317-324
20. Sperber K., Silverstein L., Brusco C., Yoon C., Mullin G.E., and Mayer L. Cytokine secretion induced by superantigens in peripheral blood mononuclear cells, lamina propria lymphocytes, and intraepithelial lymphocytes. Clin Diagn Lab Immunol 2 (1995) 473-477
21. Gasche C., Bakos S., Dejaco C., Tillinger W., Zakeri S., and Reinisch W. IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease. J Clin Immunol 20 (2000) 362-370
22. Nakamura M., Saito H., Kasanuki J., Tamura Y., and Yoshida S. Cytokine production in patients with inflammatory bowel disease. Gut 33 (1992) 933-937
23. Holtkamp W., Stollberg T., and Reis H.E. Serum interleukin-6 is related to disease activity but not disease specificity in inflammatory bowel disease. J Clin Gastroenterol 20 (1995) 123-126
24. Gross V., Andus T., Caesar I., Roth M., and Scholmerich J. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 102 (1992) 514-519
25. Bisping G., Lugering N., Lutke-Brintrup S., Pauels H.G., Schurmann G., Domschke W., and Kucharzik T. Patients with inflammatory bowel disease (IBD) reveal increased induction capacity of intracellular interferon-gamma (IFN-gamma) in peripheral CD8+ lymphocytes co-cultured with intestinal epithelial cells. Clin Exp Immunol 123 (2001) 15-22
26. Cario E., Becker A., Sturm A., Goebell H., and Dignass A.U. Peripheral blood mononuclear cells promote intestinal epithelial restitution in vitro through an interleukin-2/interferon-gamma-dependent pathway. Scand J Gastroenterol 34 (1999) 1132-1138
27. McKay D.M., and Singh P.K. Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: inhibition of increased permeability, but not diminished secretory responses by TGF-beta2. J Immunol 159 (1997) 2382-2390
28. Schmitz H., Fromm M., Bode H., Scholz P., Riecken E.O., and Schulzke J.D. Tumor necrosis factor-alpha induces Cl- and K+ secretion in human distal colon driven by prostaglandin E2. Am J Physiol 271 (1996) G669-G674
29. Oprins J.C., van der B.C., Meijer H.P., Munnik T., and Groot J.A. Tumour necrosis factor alpha potentiates ion secretion induced by histamine in a human intestinal epithelial cell line and in mouse colon: involvement of the phospholipase D pathway. Gut 50 (2002) 314-321
30. Dunlop S.P., Hebden J., Campbell E., Naesdal J., Olbe L., Perkins A.C., and Spiller R.C. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 101 (2006) 1288-1294
31. Gwee K.A., Collins S.M., Read N.W., Rajnakova A., Deng Y., Graham J.C., McKendrick M.W., and Moochhala S.M. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut 52 (2003) 523-526
32. Liebregts T., Adam B., Bertel A., Lackner C., Neumann J., Talley N.J., Gerken G., and Holtmann G. Psychological stress and the severity of post-inflammatory visceral hyperalgesia. Eur J Pain 11 (2007) 216-222
33. Kaestner F., Hettich M., Peters M., Sibrowski W., Hetzel G., Ponath G., Arolt V., Cassens U., and Rothermundt M. Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J Affect Disord 87 (2005) 305-311
34. Sykes M.A., Blanchard E.B., Lackner J., Keefer L., and Krasner S. Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med 26 (2003) 361-372
35. Maes M., Song C., Lin A., De Jongh R., Van Gastel A., Kenis G., Bosmans E., De M.I., Benoy I., Neels H., Demedts P., Janca A., Scharpe S., and Smith R.S. The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 10 (1998) 313-318
36. Miller G.E., Rohleder N., Stetler C., and Kirschbaum C. Clinical depression and regulation of the inflammatory response during acute stress. Psychosom Med 67 (2005) 679-687
37. Spath-Schwalbe E., Born J., Schrezenmeier H., Bornstein S.R., Stromeyer P., Drechsler S., Fehm H.L., and Porzsolt F. Interleukin-6 stimulates the hypothalamus-pituitary-adrenocortical axis in man. J Clin Endocrinol Metab 79 (1994) 1212-1214
38. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332 (1995) 1351-1362
39. Yirmiya R., Pollak Y., Morag M., Reichenberg A., Barak O., Avitsur R., Shavit Y., Ovadia H., Weidenfeld J., Morag A., Newman M.E., and Pollmacher T. Illness, cytokines, and depression. Ann N Y Acad Sci 917 (2000) 478-487
40. Dunn A.J. Cytokine activation of the HPA axis. Ann N Y Acad Sci 917 (2000) 608-617
41. Moss-Morris R., and Spence M. To "lump" or to "split" the functional somatic syndromes: can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome?. Psychosom Med 68 (2006) 463-469
42. Wichers M.C., Kenis G., Leue C., Koek G., Robaeys G., and Maes B. Baseline immune activation as a risk factor for the onset of depression during interferon-alpha treatment. Biol Psychiatry 60 (2007) 77-79
43. Kutukculer N., Caglayan S., and Aydogdu F. Study of pro-inflammatory (TNF-alpha, IL-1alpha, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters. Clin Rheumatol 17 (1998) 288-292
44. Schotte H., Schluter B., Willeke P., Mickholz E., Schorat M.A., Domschke W., and Gaubitz M. Long-term treatment with etanercept significantly reduces the number of proinflammatory cytokine-secreting peripheral blood mononuclear cells in patients with rheumatoid arthritis. Rheumatology (Oxford) 43 (2004) 960-964
45. Chao C.C., Janoff E.N., Hu S.X., Thomas K., Gallagher M., Tsang M., and Peterson P.K. Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome. Cytokine 3 (1991) 292-298
46. Perini F., D'Andrea G., Galloni E., Pignatelli F., Billo G., Alba S., Bussone G., and Toso V. Plasma cytokine levels in migraineurs and controls. Headache 45 (2005) 926-931
47. Svedberg P., Johansson S., Wallander M.A., Hamelin B., and Pedersen N.L. Extra-intestinal manifestations associated with irritable bowel syndrome: a twin study. Aliment Pharmacol Ther 16 (2002) 975-983
48. Whitehead W.E., Palsson O., and Jones K.R. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?. Gastroenterology 122 (2002) 1140-1156