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Volumn 108, Issue 10, 2013, Pages 1634-1643

Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: A role for PAR2

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2; SERINE PROTEINASE;

EID: 84885473060     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2013.241     Document Type: Article
Times cited : (91)

References (40)
  • 1
    • 84861167356 scopus 로고    scopus 로고
    • Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome
    • Feng B, La JH, Schwartz ES et al. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 2012; 302: G1085 - 98
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Feng, B.1    La, J.H.2    Schwartz, E.S.3
  • 3
    • 80052735711 scopus 로고    scopus 로고
    • Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome?
    • O ' Malley D, Quigley EM, Dinan TG et al. Do interactions between stress and immune responses lead to symptom exacerbations in irritable bowel syndrome? Brain Behav Immun 2011; 25: 1333-41
    • (2011) Brain Behav Immun , vol.25 , pp. 1333-1341
    • O'Malley, D.1    Quigley, E.M.2    Dinan, T.G.3
  • 4
    • 66049093837 scopus 로고    scopus 로고
    • Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite Effect on visceral sensitivity in mice
    • Annahazi A, Gecse K, Dabek M et al. Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite Effect on visceral sensitivity in mice. Pain 2009; 144: 209-17
    • (2009) Pain , vol.144 , pp. 209-217
    • Annahazi, A.1    Gecse, K.2    Dabek, M.3
  • 5
    • 10744225624 scopus 로고    scopus 로고
    • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
    • Barbara G, Stanghellini V, De GR et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702
    • (2004) Gastroenterology , vol.126 , pp. 693-702
    • Barbara, G.1    Stanghellini, V.2    De, G.R.3
  • 6
    • 33846193703 scopus 로고    scopus 로고
    • Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome
    • Barbara G, Wang B, Stanghellini V et al. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007; 132: 26-37
    • (2007) Gastroenterology , vol.132 , pp. 26-37
    • Barbara, G.1    Wang, B.2    Stanghellini, V.3
  • 7
    • 70349423402 scopus 로고    scopus 로고
    • Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    • Buhner S, Li Q, Vignali S et al. Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 2009; 137: 1425-34
    • (2009) Gastroenterology , vol.137 , pp. 1425-1434
    • Buhner, S.1    Li, Q.2    Vignali, S.3
  • 8
    • 33847342529 scopus 로고    scopus 로고
    • Role for protease activity in visceral pain in irritable bowel syndrome
    • Cenac N, Andrews CN, Holzhausen M et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007; 117: 636-47
    • (2007) J Clin Invest , vol.117 , pp. 636-647
    • Cenac, N.1    Andrews, C.N.2    Holzhausen, M.3
  • 9
    • 42549168553 scopus 로고    scopus 로고
    • Increased faecal serine protease activity in diarrhoeic IBS patients: A colonic lumenal factor impairing colonic permeability and sensitivity
    • Gecse K, Roka R, Ferrier L et al. Increased faecal serine protease activity in diarrhoeic IBS patients: A colonic lumenal factor impairing colonic permeability and sensitivity. Gut 2008; 57: 591-9
    • (2008) Gut , vol.57 , pp. 591-599
    • Gecse, K.1    Roka, R.2    Ferrier, L.3
  • 10
    • 33846989359 scopus 로고    scopus 로고
    • Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum
    • Guilarte M, Santos J, de T et al. Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum. Gut 2007; 56: 203-9
    • (2007) Gut , vol.56 , pp. 203-209
    • Guilarte, M.1    Santos, J.2    De, T.3
  • 11
    • 77957929507 scopus 로고    scopus 로고
    • Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase
    • Lee JW, Park JH, Park DI et al. Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase. Dig Dis Sci 2010; 55: 2922-8
    • (2010) Dig Dis Sci , vol.55 , pp. 2922-2928
    • Lee, J.W.1    Park, J.H.2    Park, D.I.3
  • 12
    • 34247539019 scopus 로고    scopus 로고
    • A pilot study of fecal serine-protease activity: A pathophysiologic factor in diarrhea-predominant irritable bowel syndrome
    • Roka R, Rosztoczy A, Leveque M et al. A pilot study of fecal serine-protease activity: A pathophysiologic factor in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2007; 5: 550-5
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 550-555
    • Roka, R.1    Rosztoczy, A.2    Leveque, M.3
  • 13
    • 84856701533 scopus 로고    scopus 로고
    • The expression of protease-activated receptor 2 and 4 in the colon of irritable bowel syndrome patients
    • Zhao JH, Dong L, Shi HT et al. The expression of protease-activated receptor 2 and 4 in the colon of irritable bowel syndrome patients. Dig Dis Sci 2012; 57: 58-64
    • (2012) Dig Dis Sci , vol.57 , pp. 58-64
    • Zhao, J.H.1    Dong, L.2    Shi, H.T.3
  • 14
    • 2442526798 scopus 로고    scopus 로고
    • Modulation of visceral pain and Inflammation by proteaseactivated receptors
    • Vergnolle N. Modulation of visceral pain and Inflammation by proteaseactivated receptors. Br J Pharmacol 2004; 141: 1264-74
    • (2004) Br J Pharmacol , vol.141 , pp. 1264-1274
    • Vergnolle, N.1
  • 15
    • 80054846758 scopus 로고    scopus 로고
    • Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice
    • Cattaruzza F, Lyo V, Jones E et al. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology 2011; 141: 1864 - 74
    • (2011) Gastroenterology , vol.141 , pp. 1864-1874
    • Cattaruzza, F.1    Lyo, V.2    Jones, E.3
  • 16
    • 70349682326 scopus 로고    scopus 로고
    • Activation of proteaseactivated receptor-4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons
    • Karanjia R, Spreadbury I, Bautista-Cruz F et al. Activation of proteaseactivated receptor-4 inhibits the intrinsic excitability of colonic dorsal root ganglia neurons. Neurogastroenterol Motil 2009; 21: 1218-21
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 1218-1221
    • Karanjia, R.1    Spreadbury, I.2    Bautista-Cruz, F.3
  • 17
    • 84855920144 scopus 로고    scopus 로고
    • Protease activated receptor 4 status of mast cells in post infectious irritable bowel syndrome
    • e82
    • Han W, Wang Z, Lu X et al. Protease activated receptor 4 status of mast cells in post infectious irritable bowel syndrome. Neurogastroenterol Motil 2012; 24: 113 - 9, e82
    • (2012) Neurogastroenterol Motil , vol.24 , pp. 113-119
    • Han, W.1    Wang, Z.2    Lu, X.3
  • 18
    • 46349106355 scopus 로고    scopus 로고
    • Increased capsaicin receptor TRPV1- expressing sensory fi bres in irritable bowel syndrome and their correlation with abdominal pain
    • Akbar A, Yiangou Y, Facer P et al. Increased capsaicin receptor TRPV1- expressing sensory fi bres in irritable bowel syndrome and their correlation with abdominal pain. Gut 2008; 57: 923-9
    • (2008) Gut , vol.57 , pp. 923-929
    • Akbar, A.1    Yiangou, Y.2    Facer, P.3
  • 19
    • 0036083346 scopus 로고    scopus 로고
    • Activation of the mucosal immune system in irritable bowel syndrome
    • Chadwick VS, Chen W, Shu D et al. Activation of the mucosal immune system in irritable bowel syndrome. Gastroenterology 2002; 122: 1778-83
    • (2002) Gastroenterology , vol.122 , pp. 1778-1783
    • Chadwick, V.S.1    Chen, W.2    Shu, D.3
  • 20
    • 59749085184 scopus 로고    scopus 로고
    • Mucosal immune activation in irritable bowel syndrome: Gender-dependence and association with digestive symptoms
    • Cremon C, Gargano L, Morselli-Labate AM et al. Mucosal immune activation in irritable bowel syndrome: Gender-dependence and association with digestive symptoms. Am J Gastroenterol 2009; 104: 392-400
    • (2009) Am J Gastroenterol , vol.104 , pp. 392-400
    • Cremon, C.1    Gargano, L.2    Morselli-Labate, A.M.3
  • 21
    • 33645240056 scopus 로고    scopus 로고
    • Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome
    • Part 1
    • Park JH, Rhee PL, Kim HS et al. Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol Hepatol 2006; 21 (1 Part 1): 71-8
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.1 , pp. 71-78
    • Park, J.H.1    Rhee, P.L.2    Kim, H.S.3
  • 22
    • 41149133760 scopus 로고    scopus 로고
    • Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome
    • Piche T, Saint-Paul MC, Dainese R et al. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome. Gut 2008; 57: 468-73
    • (2008) Gut , vol.57 , pp. 468-473
    • Piche, T.1    Saint-Paul, M.C.2    Dainese, R.3
  • 23
    • 0033665517 scopus 로고    scopus 로고
    • Increased rectal mucosal enteroendocrine cells T lymphocytes and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
    • Spiller RC, Jenkins D, Th ornley JP et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000; 47: 804-11
    • (2000) Gut , vol.47 , pp. 804-811
    • Spiller, R.C.1    Jenkins, D.2    Thornley, J.P.3
  • 24
    • 0036893131 scopus 로고    scopus 로고
    • Full-thickness biopsy of the jejunum reveals Inflammation and enteric neuropathy in irritable bowel syndrome
    • Tornblom H, Lindberg G, Nyberg B et al. Full-thickness biopsy of the jejunum reveals Inflammation and enteric neuropathy in irritable bowel syndrome. Gastroenterology 2002; 123: 1972 - 9
    • (2002) Gastroenterology , vol.123 , pp. 1972-1979
    • Tornblom, H.1    Lindberg, G.2    Nyberg, B.3
  • 25
    • 36949037766 scopus 로고    scopus 로고
    • Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome
    • Wang SH, Dong L, Luo JY et al. Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum in patients with irritable bowel syndrome. World J Gastroenterol 2007; 13: 6041-7
    • (2007) World J Gastroenterol , vol.13 , pp. 6041-6047
    • Wang, S.H.1    Dong, L.2    Luo, J.Y.3
  • 26
    • 0027291055 scopus 로고
    • Terminal ileal mucosal mast cells in irritable bowel syndrome
    • Weston AP, Biddle WL, Bhatia PS et al. Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci 1993; 38: 1590-5
    • (1993) Dig Dis Sci , vol.38 , pp. 1590-1595
    • Weston, A.P.1    Biddle, W.L.2    Bhatia, P.S.3
  • 27
    • 77951701739 scopus 로고    scopus 로고
    • TNFalpha is a key mediator of the pronociceptive effects of mucosal supernatant from human ulcerative colitis on colonic drg neurons
    • Ibeakanma C, Vanner S. TNFalpha is a key mediator of the pronociceptive Effects of mucosal supernatant from human ulcerative colitis on colonic DRG neurons. Gut 2010; 59: 612-21
    • (2010) Gut , vol.59 , pp. 612-621
    • Ibeakanma, C.1    Vanner, S.2
  • 28
    • 0035029103 scopus 로고    scopus 로고
    • Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia
    • Luperchio SA, Schauer DB. Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes Infect 2001; 3: 333-40
    • (2001) Microbes Infect , vol.3 , pp. 333-340
    • Luperchio, S.A.1    Schauer, D.B.2
  • 29
  • 30
    • 4644290610 scopus 로고    scopus 로고
    • Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability
    • Beyak MJ, Ramji N, Krol KM et al. Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability. Am J Physiol Gastrointest Liver Physiol 2004; 287: G845 - 55
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Beyak, M.J.1    Ramji, N.2    Krol, K.M.3
  • 31
    • 0029973002 scopus 로고    scopus 로고
    • Characterization of six voltage-gated K+ currents in adult rat sensory neurons
    • Gold MS, Shuster MJ, Levine JD. Characterization of six voltage-gated K+ currents in adult rat sensory neurons. J Neurophysiol 1996; 75: 2629-46
    • (1996) J Neurophysiol , vol.75 , pp. 2629-2646
    • Gold, M.S.1    Shuster, M.J.2    Levine, J.D.3
  • 32
    • 0036083362 scopus 로고    scopus 로고
    • TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons
    • Moore BA, Stewart TM, Hill C et al. TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons. Am J Physiol Gastrointest Liver Physiol 2002; 282: G1045 - 51
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Moore, B.A.1    Stewart, T.M.2    Hill, C.3
  • 33
    • 0033152346 scopus 로고    scopus 로고
    • Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder Inflammation
    • Yoshimura N, de Groat WC. Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder Inflammation. J Neurosci 1999; 19: 4644-53
    • (1999) J Neurosci , vol.19 , pp. 4644-4653
    • Yoshimura, N.1    De Groat, W.C.2
  • 34
    • 67651100880 scopus 로고    scopus 로고
    • Citrobacter rodentium colitis evokes post-infectious hyperexcitability of mouse nociceptive colonic dorsal root ganglion neurons
    • Part 14
    • Ibeakanma C, Miranda-Morales M, Richards M et al. Citrobacter rodentium colitis evokes post-infectious hyperexcitability of mouse nociceptive colonic dorsal root ganglion neurons. J Physiol 2009; 587 (Part 14): 3505-21
    • (2009) J Physiol , vol.587 , pp. 3505-3521
    • Ibeakanma, C.1    Miranda-Morales, M.2    Richards, M.3
  • 35
    • 81855163353 scopus 로고    scopus 로고
    • Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome
    • Ibeakanma C, Ochoa-Cortes F, Miranda-Morales M et al. Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome. Gastroenterology 2011; 141: 2098-108
    • (2011) Gastroenterology , vol.141 , pp. 2098-108
    • Ibeakanma, C.1    Ochoa-Cortes, F.2    Miranda-Morales, M.3
  • 36
    • 16444371904 scopus 로고    scopus 로고
    • Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: The role of voltage-gated ion channels
    • Beyak MJ, Vanner S. Inflammation-induced hyperexcitability of nociceptive gastrointestinal DRG neurones: The role of voltage-gated ion channels. Neurogastroenterol Motil 2005; 17: 175-86
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 175-186
    • Beyak, M.J.1    Vanner, S.2
  • 37
    • 61649097087 scopus 로고    scopus 로고
    • TRPV1-expressing sensory fi bres and IBS: Links with immune function
    • Hughes PA, Brierley SM, Martin CM et al. TRPV1-expressing sensory fi bres and IBS: Links with immune function. Gut 2009; 58: 465-6
    • (2009) Gut , vol.58 , pp. 465-466
    • Hughes, P.A.1    Brierley, S.M.2    Martin, C.M.3
  • 38
    • 34547165906 scopus 로고    scopus 로고
    • Dexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats
    • Roka R, it-Belgnaoui A, Salvador-Cartier C et al. Dexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats. Gut 2007; 56: 1072-8
    • (2007) Gut , vol.56 , pp. 1072-1078
    • Roka, R.1    It-Belgnaoui, A.2    Salvador-Cartier, C.3
  • 39
    • 79960055079 scopus 로고    scopus 로고
    • Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome
    • Cremon C, Carini G, Wang B et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol 2011; 106: 1290-8
    • (2011) Am J Gastroenterol , vol.106 , pp. 1290-1298
    • Cremon, C.1    Carini, G.2    Wang, B.3
  • 40
    • 84860503881 scopus 로고    scopus 로고
    • SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine
    • Kerckhoff s AP, Ter Linde JJ, Akkermans LM et al. SERT and TPH-1 mRNA expression are reduced in irritable bowel syndrome patients regardless of visceral sensitivity state in large intestine. Am J Physiol Gastrointest Liver Physiol 2012; 302: G1053 - 60
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302
    • Kerckhoffs, A.P.1    Ter Linde, J.J.2    Akkermans, L.M.3


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