Urine sugars for in vivo gut permeability: Validation and comparisons in irritable bowel syndrome-diarrhea and controls

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 5, 2011, Pages

  Rao, Archana S ^a   Camilleri, Michael ^a   Eckert, Deborah J ^a   Busciglio, Irene ^a   Burton, Duane D ^a   Ryks, Michael ^a   Wong, Banny S ^a   Lamsam, Jesse ^b   Singh, Ravinder ^b   Zinsmeister, Alan R ^b  

^a Clinical Enteric Neuroscience Translational and Epidemiological Research Mayo Clinic   (United States)

^b Mayo Clinic   (United States)

Author keywords

Colon; Excretion; Lactulose; Mannitol; Small intestine

Indexed keywords

CARBOHYDRATE; INDIUM 111; LACTULOSE; MANNITOL; TECHNETIUM 99M;

ADULT; ARTICLE; CLINICAL ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DIARRHEA; DRUG ADMINISTRATION ROUTE; DRUG CAPSULE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; FEMALE; GLUCOSE URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; INTRACOLONIC DRUG ADMINISTRATION; IRRITABLE COLON; MALE; MICROSCOPIC COLITIS; PRIORITY JOURNAL; SCINTIGRAPHY; SMALL INTESTINE; TANDEM MASS SPECTROMETRY; ULCERATIVE COLITIS; URINARY EXCRETION; VALIDATION STUDY;

ADULT; COLITIS, MICROSCOPIC; COLITIS, ULCERATIVE; COLON; DIARRHEA; FEMALE; HUMANS; INTESTINE, SMALL; IRRITABLE BOWEL SYNDROME; LACTULOSE; MALE; MANNITOL; MIDDLE AGED; PERMEABILITY; URINE SPECIMEN COLLECTION;

EID: 80055048012     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00168.2011     Document Type: Article

References (34)

1. Anderson AD, Jain PK, Fleming S, Poon P, Mitchell CJ, MacFie J. Evaluation of a triple sugar test of colonic permeability in humans. Acta Physiol Scand 182: 171-177, 2004.
2. Bjarnason I, Hayllar J, MacPherson AJ, Russell AS. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology 104: 1832-1847, 1993.
3. Bjarnason I, MacPherson A, Hollander D. Intestinal permeability: an overview. Gastroenterology 108: 1566-1581, 1995.
4. Bjarnason I, Peters TJ, Veall N. A persistent defect in intestinal permeability in coeliac disease demonstrated by a 51Cr-labelled EDTA absorption test. Lancet 1: 323-325, 1983.
5. Camilleri M, Nadeau A, Lamsam J, Linker-Nord S, Ryks M, Burton D, Sweetser S, Zinsmeister AR, Singh R. Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion. Neurogastroenterol Motil 22: e15-e26, 2010.
6. Camilleri M, Nadeau A, Tremaine WJ, Lamsam J, Burton D, Odunsi S, Sweetser S, Singh R. Measurement of serum 7a-hydroxy-4-cholesten-3-one (or 7aC4), a surrogate test for bile acid malabsorption in health, ileal disease and irritable bowel syndrome using liquid chromatography-tan-dem mass spectrometry. Neurogastroenterol Motil 21: e734-e743, 2009.
7. Cariello R, Federico A, Sapone A, Tuccillo C, Scialdone VR, Tiso A, Miranda A, Portincasa P, Carbonara V, Palasciano G, Martorelli L, Esposito P, Carteni M, Del Vecchio Blanco C, Loguercio C. Intestinal permeability in patients with chronic liver diseases: Its relationship with the aetiology and the entity of liver damage. Dig Liver Dis 42: 200-204, 2010.
8. Corinaldesi R, Stanghellini V, Cremon C, Gargano L, Cogliandro RF, De Giorgio R, Bartesaghi G, Canovi B, Barbara G. Effect of mesala-zine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study. Aliment Pharmacol Ther 30: 245-252, 2009.
9. Dunlop SP, Hebden J, Campbell E, Naesdal J, Olbe L, Perkins AC, Spiller RC. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol 101: 1288-1294, 2006.
10. Gecse K, Róka R, Ferrier L, Leveque M, Eutamene H, Cartier C, Ait-Belgnaoui A, Rosztóczy A, Izbéki F, Fioramonti J, Wittmann T, Bueno L. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity. Gut 57: 591-599, 2008.
11. Kalaitzakis E, Johansson JE, Bjarnason I, Björnsson E. Intestinal permeability in cirrhotic patients with and without ascites. Scand J Gastroenterol 41: 326-330, 2006.
12. Keita AV, Söderholm JD. The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil 22: 718-733, 2010.
13. Kerckhoffs AP, Akkermans LM, de Smet MB, Besselink MG, Hiet-brink F, Bartelink IH, Busschers WB, Samsom M, Renooij W. Intestinal permeability in irritable bowel syndrome patients: effects of NSAIDs. Dig Dis Sci 55: 716-723, 2010.
14. Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59: 1213-1221, 2010.
15. Lee JW, Park JH, Park DI, Park JH, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI. Subjects with diarrhea-predominant IBS have increased rectal permeability responsive to tryptase. Dig Dis Sci 55: 2922-2928, 2010.
16. Liu H, Li W, Wang X, Li J, Yu W. Early gut mucosal dysfunction in patients with acute pancreatitis. Pancreas 36: 192-196, 2008.
17. Markov AG, Veshnyakova A, Fromm M, Amasheh M, Amasheh S. Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J Comp Physiol B 180: 591-598, 2010.
18. Marshall JK, Thabane M, Garg AX, Clark W, Meddings J, Collins SM, Investigators WEL. Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkteron, Ontario. Aliment Pharmacol Ther 20: 1317-1322, 2004.
19. McOmber ME, Ou CN, Shulman RJ. Effects of timing, sex, and age on site-specific gastrointestinal permeability testing in children and adults. J Pediatr Gastroenterol Nutr 50: 269-275, 2010.
20. Meddings JB, Gibbons I. Discrimination of site-specific alterations in gastrointestinal permeability in the rat. Gastroenterology 114: 83-92, 1998.
21. Miki K, Moore DJ, Butler RN, Southcott E, Couper RT, Davidson GP. The sugar permeability test reflects disease activity in children and adolescents with inflammatory bowel disease. J Pediatr 133: 750-754, 1998.
22. Moayyedi P, Ford AC, Talley NJ, Cremonini F, Foxx-Orenstein AE, Brandt LJ, Quigley EM. The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review. Gut 59: 325-332, 2010.
23. Münch A, Söderholm JD, Wallon C, Ost A, Olaison G, Ström M. Dynamics of mucosal permeability and inflammation in collagenous colitis before, during, and after loop ileostomy. Gut 54: 1126-1128, 2005.
24. Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 58: 196-201, 2009.
25. Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, Bortey E, Forbes WP, Study Group TARGET. Rifaxi-min therapy for patients with irritable bowel syndrome without constipation. N Engl J Med 364: 22-32, 2011.
26. Salim SY, Söderholm JD. Importance of disrupted intestinal barrier in inflammatory bowel diseases. Inflamm Bowel Dis 17: 362-381, 2011.
27. Sandek A, Bjarnason I, Volk HD, Crane R, Meddings JB, Niebauer J, Kalra PR, Buhner S, Hermann R, Springer J, Doehner W, von Haehling S, Anker SD, Rauchhaus M. Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure. Int J Cardiol 2010. [Epub ahead of print] doi: 10.1016/j.ijcard.2010.12.016.
28. Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou CN. Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J Pediatr 153: 646-650, 2008.
29. Smecuol E, Bai JC, Vazquez H, Kogan Z, Cabanne A, Niveloni S, Pedreira S, Boerr L, Maurino E, Meddings JB. Gastrointestinal permeability in celiac disease. Gastroenterology 112: 1129-1136, 1997.
30. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47: 804-811, 2000.
31. van Elburg RM, Uil JJ, Kokke FT, Mulder AM, van de Broek WG, Mulder CJ, Heymans HS. Repeatability of the sugar-absorption test, using lactulose and mannitol, for measuring intestinal permeability for sugars. J Pediatr Gastroenterol Nutr 20: 184-188, 1995.
32. Wallon C, Söderholm JD. Corticotropin-releasing hormone and mast cells in the regulation of mucosal barrier function in the human colon. Ann NY Acad Sci 1165: 206-210, 2009.
33. Zhou Q, Souba WW, Croce CM, Verne GN. MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome. Gut 59: 775-784, 2010.
34. Zhou Q, Zhang B, Verne GN. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain 146: 41-46, 2009.