Expression of xCT and activity of system xc- are regulated by NRF2 in human breast cancer cells in response to oxidative stress

Redox Biology

Volumn 5, Issue , 2015, Pages 33-42

  Habib, Eric ^a   Linher Melville, Katja ^a   Lin, Han Xin ^a   Singh, Gurmit ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Hydrogen peroxide; KEAP1; NRF2; Oxidative stress; System xc ; XCT

Indexed keywords

ANTIPORTER; CYSTINE; GLUTAMIC ACID; GLUTATHIONE; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XCT PROTEIN; AMINO ACID TRANSPORTER; KEAP1 PROTEIN, HUMAN; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; SIGNAL PEPTIDE; SLC7A11 PROTEIN, HUMAN;

AMINO ACID TRANSPORT; ARTICLE; BREAST CANCER; CANCER CELL; CELL NUCLEUS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE ACTIVITY; GENE CONTROL; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MCF 7 CELL LINE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN TRANSPORT; REGULATORY MECHANISM; UPREGULATION; ANTAGONISTS AND INHIBITORS; BREAST TUMOR; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MCF-7 CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN SUBUNIT; RNA INTERFERENCE;

AMINO ACID TRANSPORT SYSTEM Y+; BREAST NEOPLASMS; CELL NUCLEUS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMIC ACID; GLUTATHIONE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MCF-7 CELLS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROMOTER REGIONS, GENETIC; PROTEIN SUBUNITS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84925686332     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.03.003     Document Type: Article

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