Dual neuroprotective pathways of a pro-electrophilic compound via HSF-1-activated heat-shock proteins and Nrf2-activated phase 2 antioxidant response enzymes

Journal of Neurochemistry

Volumn 119, Issue 3, 2011, Pages 569-578

  Satoh, Takumi ^a,b   Rezaie, Tayebeh ^b   Seki, Masaaki ^b   Sunico, Carmen R ^b   Tabuchi, Takahito ^a   Kitagawa, Tomomi ^a   Yanagitai, Mika ^a   Senzaki, Mutsumi ^a   Kosegawa, Chihiro ^a   Taira, Hideharu ^a   McKercher, Scott R ^b   Hoffman, Jennifer K ^b   Roth, Gregory P ^b   Lipton, Stuart A ^b  

^a IWATE UNIVERSITY   (Japan)

^b BURNHAM INSTITUTE   (United States)

Author keywords

electrophile; HSF 1; HSP; Nrf2; phase 2

Indexed keywords

4 DIHYDROQUINONE; CHEMICAL COMPOUND; D 1; D 2; ELECTROPHILE; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; HEME OXYGENASE 1; HYDROQUINONE DERIVATIVE; NADP(H) QUININE OXIDOREDUCTASE 1; OXIDOREDUCTASE; PEROXIREDOXIN 2; PRO ELECTROPHILIC COMPOUND; PROTEIN; PROTEIN DNAJ; SODIUM INDEPENDENT CYSTINE GLUTAMATE EXCHANGER; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM STRESS; ENZYME INDUCTION; HUMAN; HUMAN CELL; NEUROPROTECTION; OXIDATION; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; WESTERN BLOTTING;

ANTIOXIDANTS; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; QUINONES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

ROSMARINUS OFFICINALIS;

EID: 80054078860     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07449.x     Document Type: Article

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