-
1
-
-
0034788985
-
The IGF system and breast cancer
-
Sachdev D, Yee D. The IGF system and breast cancer. Endocr Relat Cancer 2001;8:197-209.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 197-209
-
-
Sachdev, D.1
Yee, D.2
-
2
-
-
84857640868
-
The insulin and insulin-like growth factor receptor family in neoplasia: An update
-
Pollak M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 2012;12:159-69.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 159-169
-
-
Pollak, M.1
-
3
-
-
33244464562
-
Critical nodes in signalling pathways: Insights into insulin action
-
Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006;7:85-96.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 85-96
-
-
Taniguchi, C.M.1
Emanuelli, B.2
Kahn, C.R.3
-
4
-
-
0032540288
-
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor- I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells
-
Jackson JG, White MF, Yee D. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor- I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem 1998;273:9994-10003.
-
(1998)
J Biol Chem
, vol.273
, pp. 9994-10003
-
-
Jackson, J.G.1
White, M.F.2
Yee, D.3
-
5
-
-
33750453743
-
Insulin receptor substrates mediate distinct biological responses to insulinlike growth factor receptor activation in breast cancer cells
-
Byron SA, Horwitz KB, Richer JK, Lange CA, Zhang X, Yee D. Insulin receptor substrates mediate distinct biological responses to insulinlike growth factor receptor activation in breast cancer cells. Br J Cancer 2006;95:1220-8.
-
(2006)
Br J Cancer
, vol.95
, pp. 1220-1228
-
-
Byron, S.A.1
Horwitz, K.B.2
Richer, J.K.3
Lange, C.A.4
Zhang, X.5
Yee, D.6
-
6
-
-
0035504405
-
Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines
-
Jackson JG, Zhang X, Yoneda T, Yee D. Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines. Oncogene 2001;20:7318-25.
-
(2001)
Oncogene
, vol.20
, pp. 7318-7325
-
-
Jackson, J.G.1
Zhang, X.2
Yoneda, T.3
Yee, D.4
-
7
-
-
80052157331
-
A Randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC)
-
Kaufman PA,Ferrero JM,Bourgeois H,Kennecke H,DeBoer R, JacotW, et al. A Randomized, double-blind, placebo-controlled, phase 2 study of AMG 479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC). Cancer Res 2010;70:55-63.
-
(2010)
Cancer Res
, vol.70
, pp. 55-63
-
-
Kaufman, P.A.1
Ferrero, J.M.2
Bourgeois, H.3
Kennecke, H.4
Deboer, R.5
Jacot, W.6
-
8
-
-
84875709263
-
Targeting insulin and insulin-like growth factor signaling in breast cancer
-
Yang Y, Yee D. Targeting insulin and insulin-like growth factor signaling in breast cancer. J Mammary Gland Biol Neoplasia 2012;17:251-61.
-
(2012)
J Mammary Gland Biol Neoplasia
, vol.17
, pp. 251-261
-
-
Yang, Y.1
Yee, D.2
-
9
-
-
84863900275
-
Insulin-like growth factor receptor inhibitors: Baby or the bathwater?
-
Yee D. Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst 2012;104:975-81.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 975-981
-
-
Yee, D.1
-
10
-
-
42949126711
-
The x(c)- cystine/glutamate antiporter: A potential target for therapy of cancer and other diseases
-
Lo M, Wang YZ, Gout PW. The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases. J Cell Physiol 2008;215:593-602.
-
(2008)
J Cell Physiol
, vol.215
, pp. 593-602
-
-
Lo, M.1
Wang, Y.Z.2
Gout, P.W.3
-
11
-
-
57049132739
-
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
-
Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 2008;10:1477-83.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1477-1483
-
-
Vaughn, A.E.1
Deshmukh, M.2
-
12
-
-
0028026693
-
New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: Only antiprogestin-occupied Breceptors are switched to transcriptional agonists by cAMP
-
Sartorius CA, Groshong SD, Miller LA, Powell RL, Tung L, Takimoto GS, et al. New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied Breceptors are switched to transcriptional agonists by cAMP. Cancer Res 1994;54:3868-77.
-
(1994)
Cancer Res
, vol.54
, pp. 3868-3877
-
-
Sartorius, C.A.1
Groshong, S.D.2
Miller, L.A.3
Powell, R.L.4
Tung, L.5
Takimoto, G.S.6
-
13
-
-
67650071137
-
Targeting cancer cells byROSmediated mechanisms: A radical therapeutic approach?
-
Trachootham D, Alexandre J, Huang P. Targeting cancer cells byROSmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009;8:579-91.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
15
-
-
79952528125
-
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
-
Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, et al. CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 2011;19:387-400.
-
(2011)
Cancer Cell
, vol.19
, pp. 387-400
-
-
Ishimoto, T.1
Nagano, O.2
Yae, T.3
Tamada, M.4
Motohara, T.5
Oshima, H.6
-
16
-
-
51749088156
-
Redox regulation of cell survival
-
Trachootham D, Lu W, Ogasawara MA, Nilsa RD, Huang P. Redox regulation of cell survival. Antioxidants Redox Signal 2008;10:1343-74.
-
(2008)
Antioxidants Redox Signal
, vol.10
, pp. 1343-1374
-
-
Trachootham, D.1
Lu, W.2
Ogasawara, M.A.3
Nilsa, R.D.4
Huang, P.5
-
17
-
-
8844279091
-
Destructive cycles: The role of genomic instability and adaptation in carcinogenesis
-
Schneider BL, Kulesz-MartinM. Destructive cycles: the role of genomic instability and adaptation in carcinogenesis. Carcinogenesis 2004;25: 2033-44.
-
(2004)
Carcinogenesis
, vol.25
, pp. 2033-2044
-
-
Schneider, B.L.1
Kulesz-Martin, M.2
-
18
-
-
33847755430
-
Adaptation of energy metabolism in breast cancer brain metastases
-
Chen EI, Hewel J, Krueger JS, Tiraby C, Weber MR, Kralli A, et al. Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res 2007;67:1472-86.
-
(2007)
Cancer Res
, vol.67
, pp. 1472-1486
-
-
Chen, E.I.1
Hewel, J.2
Krueger, J.S.3
Tiraby, C.4
Weber, M.R.5
Kralli, A.6
-
19
-
-
45549089561
-
Chemosensitization of cancer by nitric oxide
-
Sullivan R, Graham CH. Chemosensitization of cancer by nitric oxide. Curr Pharm Des 2008;14:1113-23.
-
(2008)
Curr Pharm des
, vol.14
, pp. 1113-1123
-
-
Sullivan, R.1
Graham, C.H.2
-
20
-
-
27844530663
-
Redox imbalance in cystine/glutamate transporter-deficient mice
-
Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y, et al. Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem 2005;280:37423-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 37423-37429
-
-
Sato, H.1
Shiiya, A.2
Kimata, M.3
Maebara, K.4
Tamba, M.5
Sakakura, Y.6
-
21
-
-
59149104276
-
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway
-
Chen RS, Song YM, Zhou ZY, Tong T, Li Y, Fu M, et al. Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Oncogene 2009;28:599-609.
-
(2009)
Oncogene
, vol.28
, pp. 599-609
-
-
Chen, R.S.1
Song, Y.M.2
Zhou, Z.Y.3
Tong, T.4
Li, Y.5
Fu, M.6
-
22
-
-
23844486685
-
Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance
-
Huang Y, Dai Z, Barbacioru C, Sadee W. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res 2005;65:7446-54.
-
(2005)
Cancer Res
, vol.65
, pp. 7446-7454
-
-
Huang, Y.1
Dai, Z.2
Barbacioru, C.3
Sadee, W.4
-
23
-
-
77249097525
-
Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines
-
Pham AN, Blower PE, Alvarado O, Ravula R, Gout PW, Huang Y. Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. J Pharmacol Exp Ther 2010;332:949-58.
-
(2010)
J Pharmacol Exp Ther
, vol.332
, pp. 949-958
-
-
Pham, A.N.1
Blower, P.E.2
Alvarado, O.3
Ravula, R.4
Gout, P.W.5
Huang, Y.6
-
24
-
-
84863584930
-
Acquired resistance to tamoxifen is associated with loss of the type i insulin-like growth factor receptor: Implications for breast cancer treatment
-
Fagan DH, Uselman RR, Sachdev D, Yee D. Acquired resistance to tamoxifen is associated with loss of the type I insulin-like growth factor receptor: implications for breast cancer treatment. Cancer Res 2012;72:3372-80.
-
(2012)
Cancer Res
, vol.72
, pp. 3372-3380
-
-
Fagan, D.H.1
Uselman, R.R.2
Sachdev, D.3
Yee, D.4
-
25
-
-
84899528914
-
-
Oncomine [database on the Internet]. Available from
-
Oncomine [database on the Internet]. Available from: www.oncomine. org.
-
-
-
-
26
-
-
0033305004
-
Enhancement of insulin-like growth factor signaling in human breast cancer: Estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo
-
Lee AV, Jackson JG, Gooch JL, Hilsenbeck SG, Coronado-Heinsohn E, Osborne CK, et al. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. Mol Endocrinol 1999;13: 787-96.
-
(1999)
Mol Endocrinol
, vol.13
, pp. 787-796
-
-
Lee, A.V.1
Jackson, J.G.2
Gooch, J.L.3
Hilsenbeck, S.G.4
Coronado-Heinsohn, E.5
Osborne, C.K.6
-
27
-
-
79151483638
-
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
-
Gyorffy B, Lanczky A, Eklund AC, Denkert C, Budczies J, Li Q, et al. An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients. Br Cancer Res Treat 2010;123:725-31.
-
(2010)
Br Cancer Res Treat
, vol.123
, pp. 725-731
-
-
Gyorffy, B.1
Lanczky, A.2
Eklund, A.C.3
Denkert, C.4
Budczies, J.5
Li, Q.6
-
28
-
-
0018666729
-
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
-
Griffith OW, Meister A. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem 1979;254:7558-60.
-
(1979)
J Biol Chem
, vol.254
, pp. 7558-7560
-
-
Griffith, O.W.1
Meister, A.2
-
29
-
-
0035872421
-
Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen
-
Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Res 2001;61:3894-901.
-
(2001)
Cancer Res
, vol.61
, pp. 3894-3901
-
-
Leach, J.K.1
Van Tuyle, G.2
Lin, P.S.3
Schmidt-Ullrich, R.4
Mikkelsen, R.B.5
-
31
-
-
84856098594
-
Stressed tumor cell, chemosensitized cancer
-
Wiemer EA. Stressed tumor cell, chemosensitized cancer. Nat Med 2011;17:1552-4.
-
(2011)
Nat Med
, vol.17
, pp. 1552-1554
-
-
Wiemer, E.A.1
-
32
-
-
33751346643
-
CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: An early step necessary for metastasis
-
Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, et al. CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Br Cancer Res: BCR 2006;8:R59.
-
(2006)
Br Cancer Res: BCR
, vol.8
-
-
Sheridan, C.1
Kishimoto, H.2
Fuchs, R.K.3
Mehrotra, S.4
Bhat-Nakshatri, P.5
Turner, C.H.6
-
33
-
-
84885378901
-
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target
-
Timmerman LA, Holton T, Yuneva M, Louie RJ, Padro M, Daemen A, et al. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 2013;24:450-65.
-
(2013)
Cancer Cell
, vol.24
, pp. 450-465
-
-
Timmerman, L.A.1
Holton, T.2
Yuneva, M.3
Louie, R.J.4
Padro, M.5
Daemen, A.6
-
34
-
-
84880889612
-
Therapeutic destruction of insulin receptor substrates for cancer treatment
-
Reuveni H, Flashner-Abramson E, Steiner L, Makedonski K, Song R, Shir A, et al. Therapeutic destruction of insulin receptor substrates for cancer treatment. Cancer Res 2013;73:4383-94.
-
(2013)
Cancer Res
, vol.73
, pp. 4383-4394
-
-
Reuveni, H.1
Flashner-Abramson, E.2
Steiner, L.3
Makedonski, K.4
Song, R.5
Shir, A.6
-
35
-
-
80052837423
-
Specific PET imaging of xC- transporter activity using a (1)(8) F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism
-
Koglin N, Mueller A, Berndt M, Schmitt-Willich H, Toschi L, Stephens AW, et al. Specific PET imaging of xC- transporter activity using a (1)(8) F-labeled glutamate derivative reveals a dominant pathway in tumor metabolism. Clin Cancer Res 2011;17:6000-11.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6000-6011
-
-
Koglin, N.1
Mueller, A.2
Berndt, M.3
Schmitt-Willich, H.4
Toschi, L.5
Stephens, A.W.6
-
36
-
-
84866926512
-
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer
-
Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, et al. Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Clin Cancer Res 2012;18: 5427-37.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5427-5437
-
-
Baek, S.1
Choi, C.M.2
Ahn, S.H.3
Lee, J.W.4
Gong, G.5
Ryu, J.S.6
|