Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress

Journal of Neuroscience

Volumn 23, Issue 8, 2003, Pages 3394-3406

  Shih, Andy Y ^a   Johnson, Delinda A ^b   Wong, Gloria ^a   Kraft, Andrew D ^b   Jiang, Lei ^a   Erb, Heidi ^a   Johnson, Jeffrey A ^b,c   Murphy, Timothy H ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antioxidant response element; Astrocyte; Cystine deprivation; Glutathione; Neuroprotection; Nrf2; Oxidative glutamate toxicity; Oxidative stress; Phase II detoxification enzymes; Quinone reductase; System xc ; Tert butylhydroquinone; XCT

Indexed keywords

ANTIPORTER; CELL PROTEIN; GLUTAMATE CYSTEINE LIGASE; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; MULTIDRUG RESISTANCE PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XCT CYSTINE ANTIPORTER;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; FETUS; GENE OVEREXPRESSION; GLIA CELL; GLUTATHIONE METABOLISM; MIXED CELL CULTURE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT;

EID: 0037996661     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-08-03394.2003     Document Type: Article

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