4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 4, 2010, Pages 576-586

  Zhang, Yan ^a,c   Sano, Motoaki ^a,b   Shinmura, Ken ^a   Tamaki, Kayoko ^a   Katsumata, Yoshinori ^a   Matsuhashi, Tomohiro ^a   Morizane, Shintaro ^a   Ito, Hideyuki ^a   Hishiki, Takako ^a   Endo, Jin ^a   Zhou, Heping ^a   Yuasa, Shinsuke ^a   Kaneda, Ruri ^a   Suematsu, Makoto ^a   Fukuda, Keiichi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

4 Hydroxy 2 nonenal; Glutathione; Hormesis; Ischemia reperfusion injury; Nrf2

Indexed keywords

4 HYDROXYNONENAL; BUTHIONINE SULFOXIMINE; CARRIER PROTEIN; CYSTINE TRANSPORTER; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPOXIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; REOXYGENATION; REPERFUSION INJURY;

ALDEHYDES; ANIMALS; BLOTTING, WESTERN; CELL DEATH; CELLS, CULTURED; GLUTATHIONE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

MUS;

EID: 77956101963     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.05.011     Document Type: Article

References (30)

1. Conklin D., Prough R., Bhatanagar A. Aldehyde metabolism in the cardiovascular system. Mol Biosyst 2007 Feb, 3(2):136-150.
2. Watson A.D., Leitinger N., Navab M., Faull K.F., Horkko S., Witztum J.L., et al. Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem 1997 May 23, 272(21):13597-13607.
3. Liu Q., Raina A.K., Smith M.A., Sayre L.M., Perry G. Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Mol Aspects Med 2003, 24(4-5):305-313.
4. Chen C.H., Budas G.R., Churchill E.N., Disatnik M.H., Hurley T.D., Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 2008 Sep 12, 321(5895):1493-1495.
5. Honarbakhsh S., Schachter M. Vitamins and cardiovascular disease. Br J Nutr 2009 Apr, 101(8):1113-1131.
6. Uchida K., Shiraishi M., Naito Y., Torii Y., Nakamura Y., Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem 1999 Jan 22, 274(4):2234-2242.
7. Dickinson D.A., Iles K.E., Watanabe N., Iwamoto T., Zhang H., Krzywanski D.M., et al. 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. Free Radic Biol Med 2002 Oct 1, 33(7):974.
8. Chen Z.H., Saito Y., Yoshida Y., Sekine A., Noguchi N., Niki E. 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. J Biol Chem 2005 Dec 23, 280(51):41921-41927.
9. Gems D., Partridge L. Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab 2008 Mar, 7(3):200-203.
10. Iida K., Itoh K., Kumagai Y., Oyasu R., Hattori K., Kawai K., et al. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res 2004 Sep 15, 64(18):6424-6431.
11. Tokudome S., Sano M., Shinmura K., Matsuhashi T., Morizane S., Moriyama H., et al. Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase-derived PGD2 biosynthesis. J Clin Invest 2009 Jun, 119(6):1477-1488.
12. Hyafil F., Vergely C., Du Vignaud P., Grand-Perret T. In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res 1993 Oct 1, 53(19):4595-4602.
13. Kettner A., Kumar L., Anton I.M., Sasahara Y., de la Fuente M., Pivniouk V.I., et al. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med 2004 Feb 2, 199(3):357-368.
14. Motohashi H., Yamamoto M. Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 2004 Nov, 10(11):549-557.
15. Calabrese E.J., Baldwin L.A., Holland C.D. Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Anal 1999 Apr, 19(2):261-281.
16. Kharbanda R.K., Nielsen T.T., Redington A.N. Translation of remote ischaemic preconditioning into clinical practice. Lancet 2009 Oct 31, 374(9700):1557-1565.
17. Zhu H., Jia Z., Misra B.R., Zhang L., Cao Z., Yamamoto M., et al. Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress. Cardiovasc Toxicol 2008, 8(2):71-85.
18. Purdom-Dickinson S.E., Lin Y., Dedek M., Morrissy S., Johnson J., Chen Q.M. Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor. J Mol Cell Cardiol 2007 Jan, 42(1):159-176.
19. Kobayashi A., Kang M.I., Watai Y., Tong K.I., Shibata T., Uchida K., et al. Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol 2006 Jan, 26(1):221-229.
20. Hill B.G., Dranka B.P., Zou L., Chatham J.C., Darley-Usmar V.M. Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal. Biochem J 2009 Nov 15, 424(1):99-107.
21. Singh A., Lee K.J., Lee C.Y., Goldfarb R.D., Tsan M.F. Relation between myocardial glutathione content and extent of ischemia-reperfusion injury. Circulation 1989 Dec, 80(6):1795-1804.
22. Hoshida S., Kuzuya T., Yamashita N., Nishida M., Kitahara S., Hori M., et al. gamma-Glutamylcysteine ethyl ester for myocardial protection in dogs during ischemia and reperfusion. J Am Coll Cardiol 1994 Nov 1, 24(5):1391-1397.
23. Blaustein A., Deneke S.M., Stolz R.I., Baxter D., Healey N., Fanburg B.L. Myocardial glutathione depletion impairs recovery after short periods of ischemia. Circulation 1989 Nov, 80(5):1449-1457.
24. Harding H.P., Zhang Y., Zeng H., Novoa I., Lu P.D., Calfon M., et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 2003 Mar, 11(3):619-633.
25. Endo J., Sano M., Katayama T., Hishiki T., Shinmura K., Morizane S., et al. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res 2009 Nov 20, 105(11):1118-1127.
26. Sano M., Fukuda K. Activation of mitochondrial biogenesis by hormesis. Circ Res 2008 Nov 21, 103(11):1191-1193.
27. Li J., Ichikawa T., Villacorta L., Janicki J.S., Brower G.L., Yamamoto M., et al. Nrf2 protects against maladaptive cardiac responses to hemodynamic stress. Arterioscler Thromb Vasc Biol 2009.
28. Ramana K.V., Bhatnagar A., Srivastava S., Yadav U.C., Awasthi S., Awasthi Y.C., et al. Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth. J Biol Chem 2006 Jun 30, 281(26):17652-17660.
29. Veronneau M., Comte B., Des Rosiers C. Quantitative gas chromatographic-mass spectrometric assay of 4-hydroxynonenal bound to thiol proteins in ischemic/reperfused rat hearts. Free Radic Biol Med 2002 Nov 15, 33(10):1380-1388.
30. Hill B.G., Bhatnagar A. Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation. Circ Res 2009 Nov 20, 105(11):1044-1046.