Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8+ T cell function by limiting GSH and Cys availability

Free Radical Biology and Medicine

Volumn 83, Issue , 2015, Pages 77-88

  Sha, Lisa K ^a   Sha, Weixiao ^a   Kuchler, Laura ^a   Daiber, Andreas ^b   Giegerich, Annika K ^a   Weigert, Andreas ^a   Knape, Tilo ^a   Snodgrass, Ryan ^a   Schröder, Katrin ^a   Brandes, Ralf P ^a   Brüne, Bernhard ^a   Von Knethen, Andreas ^a  

^a GOETHE UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

BMDM ; CD8+ T cells; Cysteine; Cytotoxicity GCS; Freeradicals; Glutathione; Nrf2; T celltolerance; xCT

Indexed keywords

CD8 ANTIGEN; CYSTINE; GLUTATHIONE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MERCAPTOETHANOL; OVALBUMIN; RNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; HLA ANTIGEN CLASS 1; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA; NFE2L2 PROTEIN, MOUSE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CD8+ T LYMPHOCYTE; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; EX VIVO STUDY; GENE LOSS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; WILD TYPE; ANIMAL; APOPTOSIS; BONE MARROW; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; BONE MARROW; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CYSTINE; FLOW CYTOMETRY; GLUTATHIONE; HISTOCOMPATIBILITY ANTIGENS CLASS I; IMMUNOENZYME TECHNIQUES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-E2-RELATED FACTOR 2; OVALBUMIN; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84925648561     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.02.004     Document Type: Article

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