A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Biochemical and Biophysical Research Communications

Volumn 362, Issue 4, 2007, Pages 816-821

  Nioi, Paul ^a   Nguyen, Truyen ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antioxidant response element; Cullin 3; Keapl; Nrf2; Oxidative stress; Phase II drug metabolism; Redox active chemicals; Ubiquitylation

Indexed keywords

CULLIN; CULLIN 3; PROTEIN KEAP1; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BREAST CANCER; CANCER CELL; CELL CLONE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; GENE; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KEAP1 GENE; NRF2 GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NF-E2-RELATED FACTOR 2; REPRESSOR PROTEINS;

EID: 34548577395     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.051     Document Type: Article

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