Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway

Cellular Signalling

Volumn 26, Issue 3, 2014, Pages 512-520

  Qaisiya, Mohammed ^a   Coda Zabetta, Carlos Daniel ^a   Bellarosa, Cristina ^a   Tiribelli, Claudio ^a,b  

^a Fondazione Italiana Fegato ONLUS   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Antioxidant Response Element; Bilirubin neurotoxicity; Heme oxygenase 1; Nrf2 pathway; Oxidative stress; Stress response protein kinases

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; BILIRUBIN; FTH PROTEIN; GAMMA GCL C PROTEIN; GAMMA GCL M PROTEIN; GLY1 PROTEIN; HO 1 PROTEIN; ME1 PROTEIN; MESSENGER RNA; NQO1 PROTEIN; PROTEIN; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XCT PROTEIN;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ATF3 GENE; CELL PROTECTION; CELL SURVIVAL; FTH GENE; GAMMA GCL C GENE; GAMMA GCL M GENE; GENE; GLY1 GENE; HO 1 GENE; HUMAN; HUMAN CELL; ME1 GENE; NEUROBLASTOMA CELL; NQO1 GENE; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REPORTER GENE; STRESS; UPREGULATION; XCT GENE;

ACTIVATING TRANSCRIPTION FACTOR 3; ANTIOXIDANT RESPONSE ELEMENT; ARE; ATF3; BF; BILIRUBIN NEUROTOXICITY; C-JUN NH2-TERMINAL KINASES; CYSTINE/GLUTAMATE EXCHANGER SYSTEM; CYTOSOLIC MALIC ENZYME 1; EIF2Α; EUKARYOTIC TRANSLATION INITIATION FACTOR 2Α; FERRITIN HEAVY CHAIN; FREE BILIRUBIN; FTH; GLUTATHIONE; GLY1; GLYCINE UP-TAKE TRANSPORTER; GSH; HEME OXYGENASE 1; HO-1; JNK; MAPK; ME1; MITOGEN-ACTIVATED PROTEIN KINASE; N-ACETYLCYSTEIN; NAC; NADPH QUINONE OXIDOREDUCTASE 1; NF-E2 RELATED FACTOR 2; NQO1; NRF2; NRF2 PATHWAY; OS; OXIDATIVE STRESS; PERK; PHOSPHATIDYLINOSITIDE 3-KINASES; PI3K; PKC; PROTEIN KINASE C; PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM KINASE; REACTIVE OXYGEN SPECIES; ROS; STRESS RESPONSE PROTEIN KINASES; TBHQ; TERTIARY-BUTYLHYDROQUINONE; UCB; UNCONJUGATED BILIRUBIN; XCT; Γ-GCL-C; Γ-GCL-M; Γ-GLUTAMYLCYSTEINE SYNTHETASE, CATALYTIC SUBUNIT; Γ-GLUTAMYLCYSTEINE SYNTHETASE, MODULATORY SUBUNIT;

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 3; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; APOFERRITINS; BILIRUBIN; CELL LINE, TUMOR; CELL SURVIVAL; FREE RADICAL SCAVENGERS; HEME OXYGENASE-1; HEP G2 CELLS; HUMANS; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE 14; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN KINASE C; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84891086514     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.11.029     Document Type: Article

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