A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 6, 2013, Pages 729-741

  Nandar, Wint ^a   Neely, Elizabeth B ^a   Unger, Erica ^b   Connor, James R ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Gliosis; H63D HFE; Iron; Neurodegenerative disease; Oxidative stress

Indexed keywords

CYSTINE; FERRITIN; GLUTATHIONE; HEME OXYGENASE 1; HFE PROTEIN; IRON; KIDNEY INJURY MOLECULE 1; MYELIN PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; STROMAL INTERACTION MOLECULE 2; TRANSCRIPTION FACTOR NRF2; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; BRAIN; BRAIN CORTEX; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GENE MUTATION; IN VIVO STUDY; IRON KINETICS; IRON STORAGE; MALE; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; APOFERRITINS; BRAIN; HEME OXYGENASE-1; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MICROGLIA; MUTATION, MISSENSE; NERVE TISSUE PROTEINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS;

EID: 84875082623     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.02.009     Document Type: Article

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