Recent progress in studies of factors that elicit pancreatic β-cell expansion

Protein and Cell

Volumn 6, Issue 2, 2015, Pages 81-87

  Li, Qiu ^a   Lai, Zhi Chun ^a,b  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

cell proliferation replication expansion; cell signaling; pancreatic islet; cell

Indexed keywords

4 AMINOBUTYRIC ACID; BETATROPHIN; CASPASE 3; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1C; CYCLIN E; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; GLUCOKINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; INTESTINAL TREFOIL FACTOR; IODOTHYRONINE; LIOTHYRONINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OSTEOCALCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR; THYROID HORMONE; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL EXPANSION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; ENERGY EXPENDITURE; ENZYME ACTIVATION; GLUCOSE TOLERANCE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; CELL COMMUNICATION; CHEMISTRY; GENETICS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY;

CELL COMMUNICATION; CELL DIFFERENTIATION; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN-SECRETING CELLS;

EID: 84925517486     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-014-0123-3     Document Type: Article

References (74)

1. Adeghate E, Ponery AS (2002) GABA in the endocrine pancreas: Cellular localization and function in normal and diabetic rats. Tissue Cell 34:1–6
2. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S (2013) Thyroid hormone promotes postnatal rat pancreatic β-cell development and glucose-responsive insulin secretion through MAFA. Diabetes 62:1569–1580
3. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA (2012) Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proc Natl Acad Sci USA 109:3915–3920
4. Ansarullah, Lu Y, Holstein M, DeRuyter B, Rabinovitch A, Guo Z (2013) Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor. PLoS One 8:e53345
5. Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A (2014) Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes 63:819–831
6. Bock T, Pakkenberg B, Buschard K (2003) Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52:1716–1722
7. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468
8. Braun M, Ramracheya R, Bengtsson M, Clark A, Walker JN, Johnson PR, Rorsman P (2010) GABA is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes 59:1694–1701
9. Cavelti-Weder C, Shtessel M, Reuss JE, Jermendy A, Yamada T, Caballero F, Bonner-Weir S, Weir GC (2013) Pancreatic duct ligation after almost complete β-cell loss: exocrine regeneration but no evidence of β-cell regeneration. Endocrinology 154:4493–4502
10. Centers for Disease Control and Prevention (2014) National diabetes statistics report: estimates of diabetes and its burden in the United States, 2014. U.S. Department of Health and Human Services, Atlanta
11. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41–46
12. Fenalti G, Law RH, Buckle AM, Langendorf C, Tuck K, Rosado CJ, Faux NG, Mahmood K, Hampe CS, Banga JP, Wilce M, Schmidberger J, Rossjohn J, El-Kabbani O, Pike RN, Smith AI, Mackay IR, Rowley MJ, Whisstock JC (2007) GABA production by glutamic aciddecarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol 14:280–286
13. Ferron M, Hinoi E, Karsenty G, Ducy P (2008) Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266–5270
14. Furuya F, Shimura H, Asami K, Ichijo S, Takahashi K, Kaneshige M, Oikawa Y, Aida K, Endo T, Kobayashi T (2013) Ligand-bound thyroid hormone receptor contributes to reprogramming of pancreatic acinar cells into insulin-producing cells. J Biol Chem 288:16155–16166
15. Futamura M, Yao J, Li X, Bergeron R, Tran JL, Zycband E, Woods J, Zhu Y, Shao Q, Maruki-Uchida H, Goto-Shimazaki H, Langdon RB, Erion MD, Eiki J, Zhou YP (2012) Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat. Diabetologia 55:1071–1080
16. Gao J, Tian L, Weng G, Bhagroo NV, Sorenson RL, O’Brien TD, Luo J, Guo Z (2011) Stimulating beta cell replication and improving islet graft function by GPR119 agonists. Transpl Int 24:1124–1134
17. Guardado-Mendoza R, Jimenez-Ceja L, Majluf-Cruz A, Kamath S, Fiorentino TV, Casiraghi F, Velazquez AO, DeFronzo RA, Dick E, Davalli A, Folli F (2012) Impact of obesity severity and duration on pancreatic β-cell and α-cell dynamics in normoglycemic non-human primates. Int J Obes 37:1071–1078
18. Gunasekaran U, Hudgens CW, Wright BT, Maulis MF, Gannon M (2012) Differential regulation of embryonic and adult β cell replication. Cell Cycle 11:2431–2442
19. Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, Cohen JC, Hobbs HH, Murphy AJ, Yancopoulos GD, Gromada J (2014) ANGPTL8/Betatrophin does not control pancreatic beta cell expansion. Cell 159:691–696
20. Hanley SC, Austin E, Assouline-Thomas B, Kapeluto J, Blaichman J, Moosavi M, Petropavlovskaia M, Rosenberg L (2010) Beta-cell mass dynamics and islet cell plasticity in human type 2 diabetes. Endocrinology 151:1462–1472
21. Hartoft-Nielsen ML, Rasmussen AK, Bock T, Feldt-Rasmussen U, Kaas A, Buschard K (2009) Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats. Autoimmunity 42:131–138
22. Heit JJ, Karnik SK, Kim SK (2006) Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 22:311–338
23. Hull RL, Kodama K, Utzschneider KM, Carr DB, Prigeon RL, Kahn SE (2005) Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation. Diabetologia 48:1350–1358
24. Jackerott M, Lee YC, Møllgård K, Kofod H, Jensen J, Rohleder S, Neubauer N, Gaarn LW, Lykke J, Dodge R, Dalgaard LT, Søstrup B, Jensen DB, Thim L, Nexø E, Thams P, Bisgaard HC, Nielsen JH (2006) Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone. Endocrinology 147:5752–5759
25. Jörns A, Rath KJ, Terbish T, Arndt T, Meyer Zu, Vilsendorf A, Wedekind D, Hedrich HJ, Lenzen S (2010) Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. Endocrinology 151:3555–3565
26. Jörns A, Akin M, Arndt T, Terbish T, Zu Vilsendorf AM, Wedekind D, Hedrich HJ, Lenzen S (2014) Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes. J Mol Med 92:743–755
27. Kaneto H, Miyatsuka T, Kawamori D, Yamamoto K, Kato K, Shiraiwa T, Katakami N, Yamasaki Y, Matsuhisa M, Matsuoka TA (2008) PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function. Endocr J 55:235–252
28. Kaneto H, Matsuoka TA, Katakami N, Matsuhisa M (2009) Combination of MafA, PDX-1 and NeuroD is a useful tool to efficiently induce insulin-producing surrogate beta-cells. Curr Med Chem 16:3144–3151
29. Kim TK, Lee JS, Jung HS, Ha TK, Kim SM, Han N, Lee EJ, Kim TN, Kwon MJ, Lee SH, Kim MK, Rhee BD, Park JH (2014) Triiodothyronine induces proliferation of pancreatic β-cells through the MAPK/ERK pathway. Exp Clin Endocrinol Diabetes 122:240–245
30. Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU (1985) Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110–125
31. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF (2012) Human β-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 61:2205–2213
32. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130:456–469
33. Lenzen S, Bailey CJ (1984) Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr Rev 5:411–434
34. Ligon B, Ligon B, Yang J, Morin SB, Ruberti MF, Steer ML (2007) Regulation of pancreatic islet cell survival and replication by gamma-aminobutyric acid. Diabetologia 50:764–773
35. López-Acosta JF, Moreno-Amador JL, Jiménez-Palomares M, Díaz-Marrero AR, Cueto M, Perdomo G, Cózar-Castellano I (2013) Epoxypukalide induces proliferation and protects against cytokine-mediated apoptosis in primary cultures of pancreatic β-cells. PLoS One 8:e52862
36. Madsbad S, Laurberg P, Weeke J, Orskov H, Faber OK, Binder C, Krarup T, Regeur L (1981) Very early changes in circulating T3 and rT3 during development of metabolic derangement in diabetic patients. Acta Med Scand 209:385–387
37. Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838–1844
38. Mizokami A, Yasutake Y, Gao J, Matsuda M, Takahashi I, Takeuchi H, Hirata M (2013) Osteocalcin induces release of glucagon-like peptide-1 and thereby stimulates insulin secretion in mice. PLoS One 8:e57375
39. Moon H, Chon J, Joo J, Kim D, In J, Lee H, Park J, Choi J (2013) FTY720 preserved islet β-cell mass by inhibiting apoptosis and increasing survival of β-cells in db/db mice. Diabetes Metab Res Rev 29:19–24
40. Nir T, Melton DA, Dor Y (2007) Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 117:2553–2561
41. Oh YS, Lee YJ, Park K, Choi HH, Yoo S, Jun HS (2014) Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells. Eur J Pharm Sci 51:137–145
42. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y (2013) Trefoil factor 2 promotes cell proliferation in pancreatic β-cells through CXCR-4-mediated ERK1/2 phosphorylation. Endocrinology 154:54–64
43. Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 3:167–175
44. Park K (2012) Identification of YH-GKA, a novel benzamideglucokinase activator as therapeutic candidate for type 2 diabetes mellitus. Arch Pharm Res 35:2029–2033
45. Peshavaria M, Larmie BL, Lausier J, Satish B, Habibovic A, Roskens V, Larock K, Everill B, Leahy JL, Jetton TL (2006) Regulation of pancreatic beta-cell regeneration in the normoglycemic 60 % partial-pancreatectomy mouse. Diabetes 55:3289–3298
46. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC (2008) Pancreatic beta-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):32–42
47. Saisho Y, Butler AE, Manesso E, Elashoff D, Rizza RA, Butler PC (2013) β-Cell mass and turnover in humans: effects of obesity and aging. Diabetes Care 36:e112
48. Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y (2010) Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development 137:3205–3213
49. Samson MH, Vestergaard EM, Milman N, Poulsen SS, Nexo E (2008) Circulating serum trefoil factors increase dramatically during pregnancy. Scand J Clin Lab Invest 68:369–374
50. Samson MH, Poulsen SS, Obeid R, Herrmann W, Nexo E (2011) Trefoil factor family peptides in the human foetus and at birth. Eur J Clin Invest 41:785–792
51. Sanchis-Gomar F, Perez-Quilis C (2014) The p38-PGC-1α-irisin-betatrophin axis: exploring new pathways in insulin resistance. Adipocyte 3:67–68
52. Sherry NA, Kushner JA, Glandt M, Kitamura T, Brillantes AM, Herold KC (2006) Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes 55:3238–3245
53. Shirakawa J, Okuyama T, Yoshida E, Shimizu M, Horigome Y, Tuno T, Hayasaka M, Abe S, Fuse M, Togashi Y, Terauchi Y (2014) Effects of the antitumor drug OSI-906, a dual inhibitor of IGF-1 receptor and insulin receptor, on the glycemic control, β-cell functions, and β-cell proliferation in male mice. Endocrinology 155:2102–2111
54. Soltani N, Qiu H, Aleksic M, Glinka Y, Zhao F, Liu R, Li Y, Zhang N, Chakrabarti R, Ng T, Jin T, Zhang H, Lu WY, Feng ZP, Prud’homme GJ, Wang Q (2011) GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci USA 108:11692–11697
55. Song M, Park HJ (2014) Anti-inflammatory effect of Phellinuslinteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages. J Ethnopharmacol 154:311–318
56. Sorenson RL, Brelje TC (1997) Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 29:301–307
57. Stolovich-Rain M, Hija A, Grimsby J, Glaser B, Dor Y (2012) Pancreatic beta cells in very old mice retain capacity for compensatory proliferation. J Biol Chem 287:27407–27414
58. Tian J, Dang H, Chen Z, Guan A, Jin Y, Atkinson MA, Kaufman DL (2013) γ-Aminobutyric acid regulates both the survival and replication of human β-cells. Diabetes 62:3760–3765
59. Toselli C, Hyslop CM, Hughes M, Natale DR, Santamaria P, Huang CT (2014) Contribution of a non-β-cell source to β-cell mass during pregnancy. PLoS One 9:e100398
60. Truong W, Emamaullee JA, Merani S, Anderson CC, James Shapiro AM (2007) Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. Am J Transpl 7:2031–2038
61. Vetere A, Choudhary A, Burns SM, Wagner BK (2014) Targeting the pancreatic β-cell to treat diabetes. Nat Rev Drug Discov 13:278–289
62. Wang Y, Liu Y, Wang H, Li C, Qi P, Bao J (2012) Agaricusbisporuslectins mediates islet β-cell proliferation through regulation of cell cycle proteins. Exp Biol Med 237:287–296
63. Wei P, Shi M, Barnum S, Cho H, Carlson T, Fraser JD (2009) Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells. Diabetologia 52:2142–2150
64. Wei J, Hanna T, Suda N, Karsenty G, Ducy P (2014) Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a. Diabetes 63:1021–1031
65. Xiao X, Chen Z, Shiota C, Prasadan K, Guo P, El-Gohary Y, Paredes J, Welsh C, Wiersch J, Gittes GK (2013a) No evidence for β cell neogenesis in murine adult pancreas. J Clin Invest 123:2207–2217
66. Xiao X, Wiersch J, El-Gohary Y, Guo P, Prasadan K, Paredes J, Welsh C, Shiota C, Gittes GK (2013b) TGFβ receptor signaling is essential for inflammation-induced but not β-cell workload-induced β-cell proliferation. Diabetes 62:1217–1226
67. Ximenes HM, Lortz S, Jörns A, Lenzen S (2007) Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells. Life Sci 80:2045–2050
68. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W, Zhao W, Ning G, 2010 China noncommunicable disease surveillance group (2013) Prevalence and control of diabetes in Chinese adults. JAMA 310:948–959
69. Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell 153:747–758
70. Yi P, Park JS, Melton DA (2014) Perspectives on the activities of ANGPTL8/Betatrophin. Cell 159:467–468
71. Yu LG, Fernig DG, Smith JA, Milton JD, Rhodes JM (1993) Reversible inhibition of proliferation of epithelial cell lines by Agaricus bisporus (edible mushroom) lectin. Cancer Res 53:4627–4632
72. Yu LG, Fernig DG, White MR, Spiller DG, Appleton P, Evans RC, Grierson I, Smith JA, Davies H, Gerasimenko OV, Petersen OH, Milton JD, Rhodes JM (1999) Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import. J Biol Chem 274:4890–4899
73. Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T, Yang LJ, Tang D (2014) Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 63:514–525
74. Zhao Z, Choi J, Zhao C, Ma ZA (2012) FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57 (KIP2). J Biol Chem 287:5562–5573