Iodine and tri-iodo-thyronine reduce the incidence of type 1 diabetes mellitus in the autoimmune prone BB rats

Autoimmunity

Volumn 42, Issue 2, 2009, Pages 131-138

  Hartoft Nielsen, Marie Louise ^a   Rasmussen, Aase Krogh ^a   Bock, Troels ^b   Feldt Rasmussen, Ulla ^a   Kaas, Anne ^a   Buschard, Karsten ^a  

^a Rigshospitalet   (Denmark)

^b BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Beta cell mass; Insulitis; Iodine; Rats; T1DM; Thyroid hormones

Indexed keywords

6523; LIOTHYRONINE; SODIUM IODIDE; T 2752; T 3538; THYROTROPIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOBREEDING RAT; BODY WEIGHT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG RESPONSE; FEMALE; INSULITIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ONSET AGE; POSTNATAL DEVELOPMENT; RAT; SEX DIFFERENCE; SURVIVAL RATE; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; WISTAR RAT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; INSULIN-SECRETING CELLS; IODINE; RATS; RATS, INBRED BB; RATS, WISTAR; SODIUM IODIDE; THYROTROPIN; TRIIODOTHYRONINE;

EID: 58949095929     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802438774     Document Type: Article

References (38)

1. Lenzen, S., Joost, HG and Hasselblatt, A. (1976) Thyroid function and insulin secretion from the perfused pancreas in the rat. Endocrinology, 99, pp. 125-129.
2. Lenzen, S. and Kloppel, G. (1978) Insulin secretion and the morphological and metabolic characteristics of pancreatic islets of hyperthyroid ob/ob mice. Endocrinology, 103, pp. 1546-1555.
3. Jorns, A., Tiedge, M. and Lenzen, S. (2002) Thyroxine induces pancreatic beta cell apoptosis in rats. Diabetologia, 45, pp. 851-855.
4. Lenzen, S. and Bailey, CJ (1984) Thyroid hormones, gonadal and adrenocortical steroids and the function of the islets of Langerhans. Endocr Rev, 5, pp. 411-434.
5. Ahren, B., Lundquist, I., Hedner, P., Valdemarsson, S. and Schersten, B. (1985) Glucose tolerance and insulin and C-peptide responses after various insulin secretory stimuli in hyper- and hypothyroid subjects before and after treatment. Diabetes Res, 2, pp. 95-103.
6. Levin, L. and Tomer, Y. (2003) The etiology of autoimmune diabetes and thyroiditis: Evidence for common genetic susceptibility. Autoimmun Rev, 2, pp. 377-386.
7. Otonkoski, T., Andersson, S., Knip, M. and Simell, O. (1988) Maturation of insulin response to glucose during human fetal and neonatal development. Studies with perifusion of pancreatic isletlike cell clusters. Diabetes, 37, pp. 286-291.
8. Kervran, A. and Randon, J. (1980) Development of insulin release by fetal rat pancreas in vitro: Effects of glucose, amino acids, and theophylline. Diabetes, 29, pp. 673-678.
9. Montanya, E., Nacher, V., Biarnes, M. and Soler, J. (2000) Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: Role of beta-cell hyperplasia and hypertrophy. Diabetes, 49, pp. 1341-1346.
10. Svenstrup, K., Skau, M., Pakkenberg, B., Buschard, K. and Bock, T. (2002) Postnatal development of beta-cells in rats. Proposed explanatory model. APMIS, 110, pp. 372-378.
11. Scaglia, L., Cahill, CJ, Finegood, DT and Bonner-Weir, S. (1997) Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology, 138, pp. 1736-1741.
12. Atkinson, MA and Leiter, EH (1999) The NOD mouse model of type 1 diabetes: As good as it gets?. Nat Med, 5, pp. 601-604.
13. Sternthal, E., Like, AA, Sarantis, K. and Braverman, LE (1981) Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy. Diabetes, 30, pp. 1058-1061.
14. Awata, T., Guberski, DL and Like, AA (1995) Genetics of the BB rat: Association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II. Endocrinology, 136, pp. 5731-5735.
15. Buschard, K., Jorgensen, M., Aaen, K., Bock, T. and Josefsen, K. (1990) Prevention of diabetes mellitus in BB rats by neonatal stimulation of beta cells. Lancet, 335, pp. 134-135.
16. Gotfredsen, CF, Buschard, K. and Frandsen, EK (1985) Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals. Diabetologia, 28, pp. 933-935.
17. Buschard, K. (1991) The functional state of the beta cells in the pathogenesis of insulin dependent diabetes mellitus. Autoimmunity, 10, pp. 65-69.
18. Hartoft-Nielsen, ML, Rasmussen, AK, Kaas, A., Feldt-Rasmussen, U. and Buschard, K. (2004) Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats. Eur J Endocrinol, 151, pp. 375-382.
19. Buschard, K., Pedersen, C., Hansen, SV, Hageman, I., Aaen, K. and Bendtzen, K. (1992) Antidiabetogenic effect of fusidic acid in diabetes prone BB rats. Autoimmunity, 14, pp. 101-104.
20. Delesse, MA Procede mecanique pour determiner la composition des roches. CR Acad Sci Paris, 25, pp. 544-545.
21. Gundersen, HJ and Jensen, EB (1987) The efficiency of systematic sampling in stereology and its prediction. J Microsc, 147, pp. 229-263.
22. Bock, T., Kjaer, TW, Jorgensen, M., Josefsen, K., Rygaard, J. and Buschard, K. (1991) Reduction of diabetes incidence in NOD mice by neonatal glucose treatment. APMIS, 99, pp. 989-992.
23. Dussault, JH and Labrie, F. (1975) Development of the hypothalamic-pituitary-thyroid axis in the neonatal rat. Endocrinology, 97, pp. 1321-1324.
24. Oberkotter, LV (1988) Developmental changes in rat thyroid responsiveness to thyrotropin administered by the subcutaneous and peroral route. Proc Soc Exp Biol Med, 187, pp. 360-365.
25. Atkinson, MA, Maclaren, NK and Luchetta, R. (1990) Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes, 39, pp. 933-937.
26. Banovac, K., Ghandur-Mnaymneh, L., Zakarija, M., Rabinovitch, A. and McKenzie, JM (1988) The effect of thyroxine on spontaneous thyroiditis in BB/W rats. Int Arch Allergy Appl Immunol, 87, pp. 301-305.
27. Gottlieb, PA, Handler, ES, Appel, MC, Greiner, DL, Mordes, JP and Rossini, AA (1991) Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats. Diabetologia, 34, pp. 296-300.
28. Maruyama, T., Shimada, A. Kanatsuka, A. et al. (2003) Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): Preliminary report. Ann N Y Acad Sci, 1005, pp. 362-369.
29. Ortqvist, E., Bjork, E. Wallensteen, M. et al. (2004) Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes. Diabetes Care, 27, pp. 2191-2197.
30. Fourlanos, S., Narendran, P., Byrnes, GB, Colman, PG and Harrison, LC (2004) Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia, pp. 1661-1667.
31. Like, AA, Biron, CA, Weringer, EJ, Byman, K., Sroczynski, E. and Guberski, DL (1986) Prevention of diabetes in BioBreeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J Exp Med, 164, pp. 1145-1159.
32. Palmer, JP, Helqvist, S. Spinas, GA et al. (1989) Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes, 38, pp. 1211-1216.
33. Bock, T., Kyhnel, A., Pakkenberg, B. and Buschard, K. (2003) The postnatal growth of the beta-cell mass in pigs. J Endocrinol, 179, pp. 245-252.
34. Mooij, P., Wit, HJ and Drexhage, HA (1993) An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats. Clin Immunol Immunopathol, 69, pp. 189-198.
35. Mihara, S., Suzuki, N. Wakisaka, S. et al. (1999) Effects of thyroid hormones on apoptotic cell death of human lymphocytes. J Clin Endocrinol Metab, 84, pp. 1378-1385.
36. Arpin, C., Pihlgren, M. Fraichard, A. et al. (2000) Effects of T3R alpha 1 and T3R alpha 2 gene deletion on T and B lymphocyte development. J Immunol, 164, pp. 152-160.
37. Botella-Carretero, JI, Prados, A. Manzano, L. et al. (2005) The effects of thyroid hormones on circulating markers of cell-mediated immune response, as studied in patients with differentiated thyroid carcinoma before and during thyroxine withdrawal. Eur J Endocrinol, 153, pp. 223-230.
38. Klecha, AJ, Genaro, AM Gorelik, G. et al. (2006) Integrative study of hypothalamus-pituitary-thyroid-immune system interaction: Thyroid hormone-mediated modulation of lymphocyte activity through the protein kinase C signaling pathway. J Endocrinol, 189, pp. 45-55.