FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57 KIP2

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5562-5573

  Zhao, Zhengshan ^a   Choi, Jinwoo ^a   Zhao, Chunying ^a   Ma, Zhongmin Alex ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD GLUCOSE; CELL MASS; CELL REGENERATION; CYCLIN D3; CYCLIN-DEPENDENT KINASE INHIBITORS; DB/DB MOUSE; IN-VIVO; INSULIN SENSITIVITY; ORAL ADMINISTRATION; PANCREATIC DUCTS; PATHOPHYSIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNALING PATHWAYS; SPHINGOSINE 1 PHOSPHATES; THERAPEUTIC STRATEGY; TYPE-2 DIABETES;

BLOOD; CELL PROLIFERATION; CYTOLOGY; GLUCOSE; INSULIN; MAMMALS; PHYSIOLOGICAL MODELS;

CELLS;

BROXURIDINE; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1C; FINGOLIMOD; GLUCOSE; INSULIN; KI 67 ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; TRANSCRIPTION FACTOR PDX 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CELLULAR PARAMETERS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MOUSE; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PANCREATIC BETA CELL MASS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; CELL COUNT; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN D3; CYCLIN-DEPENDENT KINASE INHIBITOR P57; DOWN-REGULATION; FEMALE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; UP-REGULATION;

EID: 84863129902     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.305359     Document Type: Article

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