Circulating serum trefoil factors increase dramatically during pregnancy

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 68, Issue 5, 2008, Pages 369-374

  Hessellund Samson, M ^a   Vestergaard, E M ^a   Milman, N ^b   Seier Poulsen, S ^b   Nexo, E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Down syndrome; Human TFF1 protein; Human TFF2 protein; Human TFF3 protein; Mass screening; Pregnancy; Prenatal diagnosis; Serum; Trisomy

Indexed keywords

TREFOIL PEPTIDE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GESTATIONAL AGE; HUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PUERPERIUM; TRISOMY 21;

ADENOSINE TRIPHOSPHATASES; CHROMATOGRAPHY, GEL; DNA-BINDING PROTEINS; FEMALE; HUMANS; PEPTIDES; PREGNANCY; TRANSCRIPTION FACTORS; TRISOMY;

LOTUS;

EID: 50449086908     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510701767862     Document Type: Article

References (27)

1. Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res 1982;10:7895-903.
2. Jakowlew SB, Breathnach R, Jeltsch JM, Masiakowski P, Chambon P. Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7. Nucleic Acids Res 1984;12:2861-78.
3. Jorgensen KH, Thim L, Jacobsen HE. Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas. Regul Pept 1982;3:207-19.
4. Thim L, Jorgensen KH, Jorgensen KD. Pancreatic spasmolytic polypeptide (PSP): II. Radioimmunological determination of PSP in porcine tissues, plasma and pancreatic juice. Regul Pept 1982;3:221-30.
5. Suemori S, Lynch-Devaney K, Podolsky DK. Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family. Proc Natl Acad Sci USA 1991;88:11017-21.
6. Hauser F, Poulsom R, Chinery R, Rogers LA, Hanby AM, Wright NA, et al. hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 1993;90:6961-5.
7. Podolsky DK, Lynch-Devaney K, Stow JL, Oates P, Murgue B, DeBeaumont M, et al. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion. J Biol Chem 1993;268:6694-702.
8. Thim L, May FE. Structure of mammalian trefoil factors and functional insights. Cell Mol Life Sci 2005;62:2956-73.
9. Hoffmann W. Trefoil factor family (TFF) peptides: regulators of mucosal regeneration and repair, and more. Peptides 2004;25:727-30.
10. Emami S, Rodrigues S, Rodrigue CM, Le Floch N, Rivat C, Attoub S, et al. Trefoil factor family (TFF) peptides and cancer progression. Peptides 2004;25:885-98.
11. Gronbaek H, Vestergaard EM, Hey H, Nielsen JN, Nexo E. Serum trefoil factors in patients with inflammatory bowel disease. Digestion 2006;74:33-9.
12. Vestergaard EM, Borre M, Poulsen SS, Nexo E, Torring N. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clin Cancer Res 2006;12:807-12.
13. Vestergaard EM, Brynskov J, Ejskjaer K, Clausen JT, Thim L, Nexo E, et al. Immunoassays of human trefoil factors 1 and 2: Measured on serum from patients with inflammatory bowel disease. Scand J Clin Lab Invest 2004;64:146-56.
14. Vestergaard EM, Poulsen SS, Gronbaek H, Larsen R, Nielsen AM, Ejskjaer K, et al. Development and evaluation of an ELISA for human trefoil factor 3. Clin Chem 2002;48:1689-95.
15. Seib T, Blin N, Hilgert K, Seifert M, Theisinger B, Engel M, et al. The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. Genomics 1997;40:200-2.
16. Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nat Rev Genet 2004;5:725-38.
17. FitzPatrick DR, Ramsay J, McGill NI, Shade M, Carothers AD, Hastie ND. Transcriptome analysis of human autosomal trisomy. Hum Mol Genet 2002;11:3249-56.
18. Milman N, Bergholt T, Eriksen L, Byg K, Graudal N, Pedersen P, et al. Iron prophylaxis during pregnancy - how much iron is needed? A randomized dose-response study of 20-80 mg ferrous iron daily in pregnant women. Acta Obstet Gynecol Scand 2005;84:238-47.
19. Ackers GK. Molecular exclusion and restricted diffusion processes in molecular-sieve chromatography. Biochemistry 1964;3:723-30.
20. May FE, Semple JI, Newton JL, Westley BR. The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach. Gut 2000;46:454-9.
21. May FE, Church ST, Major S, Westley BR. The closely related estrogen-regulated trefoil proteins TFF1 and TFF3 have markedly different hydrodynamic properties, overall charge, and distribution of surface charge. Biochemistry 2003;42:8250-9.
22. Newton JL, Allen A, Westley BR, May FE. The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach. Gut 2000;46:312-20.
23. Westley BR, Griffin SM, May FE. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 2005;44:7967-75.
24. Piggott NH, Henry JA, May FE, Westley BR. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. J Pathol 1991;163:95-104.
25. Poulsom R, Hanby AM, Lalani EN, Hauser F, Hoffmann W, Stamp GW. Intestinal trefoil factor (TFF 3) and pS2 (TFF 1), but not spasmolytic polypeptide (TFF 2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium. J Pathol 1997;183:30-8.
26. Wiede A, Hinz M, Canzler E, Franke K, Quednow C, Hoffmann W. Synthesis and localization of the mucin-associated TFF-peptides in the human uterus. Cell Tissue Res 2001;303:109-15.
27. Madsen J, Nielsen O, Tornoe I, Thim L, Holmskov U. Tissue localization of human trefoil factors 1, 2, and 3. J Histochem Cytochem 2007;55:505-13.