Treatment with glucokinase activator, YH-GKA, increases cell proliferation and decreases glucotoxic apoptosis in INS-1 cells

European Journal of Pharmaceutical Sciences

Volumn 51, Issue 1, 2014, Pages 137-145

  Oh, Yoon Sin ^a,b   Lee, Youn Jung ^a   Park, Kaapjoo ^c   Choi, Hyun Ho ^c   Yoo, Sangjong ^a   Jun, Hee Sook ^a,b  

^a Gachon University College of Medicine   (South Korea)

^b Gachon University Gil Hospital   (South Korea)

^c Yuhan Research Institute   (South Korea)

Author keywords

Apoptosis; Beta cell proliferation; Glucokinase activator; Glucotoxicity; INS 1 cells; Type 2 diabetes

Indexed keywords

ADENOSINE TRIPHOSPHATE; BENZAMIDE DERIVATIVE; BETA CATENIN; CASPASE 3; CITRATE SYNTHASE; CYCLIN D2; GLUCOKINASE; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR SUBSTRATE 2; LIPOCORTIN 5; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL; YH GKA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; STAINING; UPREGULATION;

APOPTOSIS; B-CELL LYMPHOMA; BAX; BCL; BCL-2-ASSOCIATED X PROTEIN; BETA-CELL PROLIFERATION; CITRATE SYNTHASE; CS; GKA; GLUCOKINASE ACTIVATOR; GLUCOTOXICITY; GLYCOGEN SYNTHASE KINASE; GSK; INS-1 CELLS; INSULIN RECEPTOR SUBSTRATE-2; IRS-2; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOCHONDRIAL TRANSMEMBRANE POTENTIAL; PARP; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PGC-1Α; POLY (ADP-RIBOSE) POLYMERASE; TFAM; TYPE 2 DIABETES; VDAC; VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL PROTEIN; ΔΨM;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BENZAMIDES; BETA CATENIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CITRATE (SI)-SYNTHASE; CYCLIN D2; GLUCOKINASE; GLYCOGEN SYNTHASE KINASE 3; INSULIN RECEPTOR SUBSTRATE PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; RATS;

EID: 84885737056     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.09.005     Document Type: Article

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