Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a

Diabetes

Volumn 63, Issue 3, 2014, Pages 1021-1031

  Wei, Jianwen ^a   Hanna, Timothy ^a   Suda, Nina ^a   Karsenty, Gerard ^a   Ducy, Patricia ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMALS; CELL LINEAGE; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN D1; GLUCOSE INTOLERANCE; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; OSTEOCALCIN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84894500766     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0887     Document Type: Article

References (44)

1. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812
2. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. b-cell deficit and increased b-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110
3. Muoio DM, Newgard CB. Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 2008;9:193-205
4. Atkinson MA, Bluestone JA, Eisenbarth GS, et al. How does type 1 diabetes develop? The notion of homicide or b-cell suicide revisited. Diabetes 2011; 60:1370-1379
5. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 2005;48:2221-2228
6. Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Horm Metab Res 1997;29:301-307
7. Georgia S, Bhushan A. Pregnancy hormones boost beta cells via serotonin. Nat Med 2010;16:756-757
8. Ackermann AM, Gannon M. Molecular regulation of pancreatic b-cell mass development, maintenance, and expansion. J Mol Endocrinol 2007;38: 193-206
9. Köhler CU, Olewinski M, Tannapfel A, Schmidt WE, Fritsch H, Meier JJ. Cell cycle control of b-cell replication in the prenatal and postnatal human pancreas. Am J Physiol Endocrinol Metab 2011;300:E221-E230
10. Dhawan S, Georgia S, Bhushan A. Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol 2007;19:634-645
11. Bouwens L, Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev 2005;85:1255-1270
12. Meier JJ, Butler AE, Saisho Y, et al. b-cell replication is the primary mechanism subserving the postnatal expansion of b-cell mass in humans. Diabetes 2008;57:1584-1594
13. Kushner JA. b-cell growth: an unusual paradigm of organogenesis that is cyclin D2/Cdk4 dependent. Cell Cycle 2006;5:234-237
14. Kushner JA, Ciemerych MA, Sicinska E, et al. Cyclins D2 and D1 are essential for postnatal pancreatic b-cell growth. Mol Cell Biol 2005;25:3752-3762
15. Georgia S, Bhushan A. b cell replication is the primary mechanism for maintaining postnatal b cell mass. J Clin Invest 2004;114:963-968
16. Rane SG, Dubus P, Mettus RV, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in b-islet cell hyperplasia. Nat Genet 1999;22:44-52
17. Kim SY, Rane SG. The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors. Development 2011;138:1903-1912
18. Ferron M, Hinoi E, Karsenty G, Ducy P. Osteocalcin differentially regulates b cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A 2008;105:5266-5270
19. Gannon M, Ables ET, Crawford L, et al. pdx-1 Function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 2008;314:406-417
20. Inada A, Hamamoto Y, Tsuura Y, et al. Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic b cells. Mol Cell Biol 2004;24:2831-2841
21. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF. Human b-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 2012;61:2205-2213
22. Miralles F, Portha B. Early development of b-cells is impaired in the GK rat model of type 2 diabetes. Diabetes 2001;50(Suppl. 1):S84-S88
23. Movassat J, Saulnier C, Serradas P, Portha B. Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat. Diabetologia 1997;40:916-925
24. Ferron M, Wei J, Yoshizawa T, et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010;142:296-308
25. Yoshizawa T, Hinoi E, Jung DY, et al. The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 2009;119:2807-2817
26. Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007;130:456-469
27. Hinoi E, Gao N, Jung DY, et al. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 2008;183:1235-1242
28. Fulzele K, Riddle RC, DiGirolamo DJ, et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 2010;142:309-319
29. Oury F, Sumara G, Sumara O, et al. Endocrine regulation of male fertility by the skeleton. Cell 2011;144:796-809
30. Kuang D, Yao Y, Lam J, Tsushima RG, Hampson DR. Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem 2005;93:383-391
31. Ducy P, Desbois C, Boyce B, et al. Increased bone formation in osteocalcindeficient mice. Nature 1996;382:448-452
32. Hingorani SR, Petricoin EF, Maitra A, et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003; 4:437-450
33. Ferron M, Wei J, Yoshizawa T, Ducy P, Karsenty G. An ELISA-based method to quantify osteocalcin carboxylation in mice. Biochem Biophys Res Commun 2010;397:691-696
34. Pi M, Wu Y, Quarles LD. GPRC6A mediates responses to osteocalcin in b-cells in vitro and pancreas in vivo. J Bone Miner Res 2011;26:1680-1683
35. Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997;88:561-572
36. Mastracci TL, Wilcox CL, Arnes L, et al. Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol 2011;359:1-11
37. Pi M, Faber P, Ekema G, et al. Identification of a novel extracellular cationsensing G-protein-coupled receptor. J Biol Chem 2005;280:40201-40209
38. Ferron M, McKee MD, Levine RL, Ducy P, Karsenty G. Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice. Bone 2012;50:568-575
39. Ducy P. The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 2011;54:1291-1297
40. de Paula FJ, Horowitz MC, Rosen CJ. Novel insights into the relationship between diabetes and osteoporosis. Diabetes Metab Res Rev 2010;26: 622-630
41. Goran MI, Shaibi GQ, Weigensberg MJ, Davis JN, Cruz ML. Deterioration of insulin sensitivity and beta-cell function in overweight Hispanic children during pubertal transition: a longitudinal assessment. Int J Pediatr Obes 2006;1:139-145
42. Rosenbaum M, Nonas C, Horlick M, et al.; Camino Diabetes Prevention Group. beta-Cell function and insulin sensitivity in early adolescence: association with body fatness and family history of type 2 diabetes mellitus. J Clin Endocrinol Metab 2004;89:5469-5476
43. Andralojc K, Srinivas M, Brom M, et al. Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis. Diabetologia 2012; 55:1247-1257
44. Oury F, Ferron M, Huizhen W, et al. Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Invest 2013; 123:2421-2433