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Volumn 29, Issue 1, 2013, Pages 19-24

FTY720 preserved islet β-cell mass by inhibiting apoptosis and increasing survival of β-cells in db/db mice

Author keywords

cell mass; FTY720; Sphingosine 1 phosphate

Indexed keywords

FINGOLIMOD; GLUCOSE; INSULIN;

EID: 84872224190     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2341     Document Type: Article
Times cited : (30)

References (32)
  • 1
    • 77954988574 scopus 로고    scopus 로고
    • Imaging of β-cell mass and function
    • Ichise M, Harris P. Imaging of β-cell mass and function. J Nucl Med 2010; 51: 1001-1004.
    • (2010) J Nucl Med , vol.51 , pp. 1001-1004
    • Ichise, M.1    Harris, P.2
  • 2
    • 0037219411 scopus 로고    scopus 로고
    • Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    • Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52(1): 102-110.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 102-110
    • Butler, A.E.1    Janson, J.2    Bonner-Weir, S.3    Ritzel, R.4    Rizza, R.A.5    Butler, P.C.6
  • 3
    • 0037283601 scopus 로고    scopus 로고
    • The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kan SE. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 2003; 46(1): 3-19.
    • (2003) Diabetologia , vol.46 , Issue.1 , pp. 3-19
    • Kan, S.E.1
  • 4
    • 0037191135 scopus 로고    scopus 로고
    • Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities
    • LeRoith D. Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 2002; 113(Suppl 6A): 3S-11S.
    • (2002) Am J Med , vol.113 A , Issue.SUPPL. 6
    • LeRoith, D.1
  • 5
    • 0038707331 scopus 로고    scopus 로고
    • Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea
    • 230.
    • Yoon KH, Ko SH, Cho JH, et al. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab 2003; 88(5): 2300-2308.
    • (2003) J Clin Endocrinol Metab , vol.88 , Issue.5 , pp. 2300-2308
    • Yoon, K.H.1    Ko, S.H.2    Cho, J.H.3
  • 6
    • 79952817657 scopus 로고    scopus 로고
    • Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines
    • El-Azab MF, Attia FM, El-Mowafy AM. Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines. Eur J Pharmacol 2011; 658(1): 41-48.
    • (2011) Eur J Pharmacol , vol.658 , Issue.1 , pp. 41-48
    • El-Azab, M.F.1    Attia, F.M.2    El-Mowafy, A.M.3
  • 7
    • 80054840916 scopus 로고    scopus 로고
    • Antioxidant treatment may protect pancreatic beta cells through the attenuation of islet fibrosis in an animal model of type 2 diabetes
    • Lee E, Ryu GR, Ko SH, et al. Antioxidant treatment may protect pancreatic beta cells through the attenuation of islet fibrosis in an animal model of type 2 diabetes. Biochem Biophys Res Commun 2011; 414(2): 397-402.
    • (2011) Biochem Biophys Res Commun , vol.414 , Issue.2 , pp. 397-402
    • Lee, E.1    Ryu, G.R.2    Ko, S.H.3
  • 8
    • 77749234186 scopus 로고    scopus 로고
    • Current status of islet cell replacement and regeneration therapy
    • Halban PA, German MS, Kahn SE, Weir GC. Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab 2010; 95(3): 1034-1043.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.3 , pp. 1034-1043
    • Halban, P.A.1    German, M.S.2    Kahn, S.E.3    Weir, G.C.4
  • 9
    • 33947168769 scopus 로고    scopus 로고
    • FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis
    • Baumruker T, Billich A, Brinkmann V. FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. Expert Opin Investig Drugs 2007; 16(3): 283-289.
    • (2007) Expert Opin Investig Drugs , vol.16 , Issue.3 , pp. 283-289
    • Baumruker, T.1    Billich, A.2    Brinkmann, V.3
  • 10
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277(24): 21453-21457.
    • (2002) J Biol Chem , vol.277 , Issue.24 , pp. 21453-21457
    • Brinkmann, V.1    Davis, M.D.2    Heise, C.E.3
  • 11
    • 77949425176 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications
    • Verzijl D, Peters SL, Alewijnse AE. Sphingosine-1-phosphate receptors: zooming in on ligand-induced intracellular trafficking and its functional implications. Mol Cells 2010; 29(2): 99-104.
    • (2010) Mol Cells , vol.29 , Issue.2 , pp. 99-104
    • Verzijl, D.1    Peters, S.L.2    Alewijnse, A.E.3
  • 12
    • 34748825490 scopus 로고    scopus 로고
    • Fingolimod: a novel immunosuppressant for multiple sclerosis
    • Brown BA, Kantesaria PP, McDevitt LM. Fingolimod: a novel immunosuppressant for multiple sclerosis. Ann Pharmacother 2007; 41(10): 1660-1668.
    • (2007) Ann Pharmacother , vol.41 , Issue.10 , pp. 1660-1668
    • Brown, B.A.1    Kantesaria, P.P.2    McDevitt, L.M.3
  • 13
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010; 362(5): 402-415.
    • (2010) N Engl J Med , vol.362 , Issue.5 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 14
    • 78049480679 scopus 로고    scopus 로고
    • Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
    • Brinkmann V, Billich A, Baumruker T, et al. Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis. Nat Rev Drug Discov 2010; 9(11): 883-897.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.11 , pp. 883-897
    • Brinkmann, V.1    Billich, A.2    Baumruker, T.3
  • 15
    • 0037184806 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice
    • Maki T, Gottschalk R, Monaco AP. Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice. Transplantation 2002; 74(12): 1684-1686.
    • (2002) Transplantation , vol.74 , Issue.12 , pp. 1684-1686
    • Maki, T.1    Gottschalk, R.2    Monaco, A.P.3
  • 16
    • 18644366150 scopus 로고    scopus 로고
    • Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720
    • Maki T, Gottschalk R, Ogawa N, Monaco AP. Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation 2005; 79(9): 1051-1055.
    • (2005) Transplantation , vol.79 , Issue.9 , pp. 1051-1055
    • Maki, T.1    Gottschalk, R.2    Ogawa, N.3    Monaco, A.P.4
  • 17
    • 0037961801 scopus 로고    scopus 로고
    • The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice
    • Yang Z, Chen M, Fialkow LB, et al. The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice. Clin Immunol 2003; 107(1): 30-35.
    • (2003) Clin Immunol , vol.107 , Issue.1 , pp. 30-35
    • Yang, Z.1    Chen, M.2    Fialkow, L.B.3
  • 18
    • 79551523750 scopus 로고    scopus 로고
    • Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells
    • Morris MA, McDuffie M, Nadler JL, Ley K. Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells. Autoimmunity 2011; 44(2): 115-128.
    • (2011) Autoimmunity , vol.44 , Issue.2 , pp. 115-128
    • Morris, M.A.1    McDuffie, M.2    Nadler, J.L.3    Ley, K.4
  • 19
    • 33846593489 scopus 로고    scopus 로고
    • New immunosuppressor strategies in the treatment of murine lupus nephritis
    • Alperovich G, Rama I, Lloberas N, et al. New immunosuppressor strategies in the treatment of murine lupus nephritis. Lupus 2007; 16(1): 18-24.
    • (2007) Lupus , vol.16 , Issue.1 , pp. 18-24
    • Alperovich, G.1    Rama, I.2    Lloberas, N.3
  • 20
    • 84863129902 scopus 로고    scopus 로고
    • FTY720 normalizes hyperglycemia by stimulating β-cell in-vivo regeneration in db/db mice through the regulation of cyclin D3 and p57KIP2
    • Zhao Z, Choi J, Zhao C, Ma ZA. FTY720 normalizes hyperglycemia by stimulating β-cell in-vivo regeneration in db/db mice through the regulation of cyclin D3 and p57KIP2. J Biol Chem 2012; 287(8): 5562-5573.
    • (2012) J Biol Chem , vol.287 , Issue.8 , pp. 5562-5573
    • Zhao, Z.1    Choi, J.2    Zhao, C.3    Ma, Z.A.4
  • 21
    • 80052590678 scopus 로고    scopus 로고
    • Advanced glycation end products downregulate glucokinase in mice
    • Jung H, Joo J, Jeon Y, et al. Advanced glycation end products downregulate glucokinase in mice. Diabetes Metab Res Rev 2011; 27(6): 557-563.
    • (2011) Diabetes Metab Res Rev , vol.27 , Issue.6 , pp. 557-563
    • Jung, H.1    Joo, J.2    Jeon, Y.3
  • 22
    • 66649125230 scopus 로고    scopus 로고
    • Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis
    • Zhao Z, Zhao C, Zhang XH, et al. Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis. Endocrinology 2009; 150(6): 2569-2576.
    • (2009) Endocrinology , vol.150 , Issue.6 , pp. 2569-2576
    • Zhao, Z.1    Zhao, C.2    Zhang, X.H.3
  • 23
    • 0014042613 scopus 로고
    • Method for the isolation of intact islets of Langerhans from the rat pancreas
    • Lacy PE, Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967; 16(1): 35-39.
    • (1967) Diabetes , vol.16 , Issue.1 , pp. 35-39
    • Lacy, P.E.1    Kostianovsky, M.2
  • 24
    • 0029857032 scopus 로고    scopus 로고
    • A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes
    • Suzuki S, Li XK, Enosawa S, Shinomiya T. A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes. Immunology 1996; 89(4): 518-523.
    • (1996) Immunology , vol.89 , Issue.4 , pp. 518-523
    • Suzuki, S.1    Li, X.K.2    Enosawa, S.3    Shinomiya, T.4
  • 25
    • 0033559508 scopus 로고    scopus 로고
    • Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway
    • Matsuda S, Minowa A, Suzuki S, Koyasu S. Differential activation of c-Jun NH2-terminal kinase and p38 pathways during FTY720-induced apoptosis of T lymphocytes that is suppressed by the extracellular signal-regulated kinase pathway. J Immunol 1999; 162: 3321-3326.
    • (1999) J Immunol , vol.162 , pp. 3321-3326
    • Matsuda, S.1    Minowa, A.2    Suzuki, S.3    Koyasu, S.4
  • 26
    • 0034665512 scopus 로고    scopus 로고
    • Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria
    • Nagahara Y, Ikekita M, Shinomiya T. Immunosuppressant FTY720 induces apoptosis by direct induction of permeability transition and release of cytochrome c from mitochondria. J Immunol 2000; 165: 3250-3259.
    • (2000) J Immunol , vol.165 , pp. 3250-3259
    • Nagahara, Y.1    Ikekita, M.2    Shinomiya, T.3
  • 27
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277(24): 21453-21457.
    • (2002) J Biol Chem , vol.277 , Issue.24 , pp. 21453-21457
    • Brinkmann, V.1    Davis, M.D.2    Heise, C.E.3
  • 28
    • 0036494268 scopus 로고    scopus 로고
    • Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models
    • Azuma H, Takahara S, Ichimaru N, et al. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models. Cancer Res 2002; 62(5): 1410-1419.
    • (2002) Cancer Res , vol.62 , Issue.5 , pp. 1410-1419
    • Azuma, H.1    Takahara, S.2    Ichimaru, N.3
  • 29
    • 0036773971 scopus 로고    scopus 로고
    • FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
    • Brinkmann V, Lynch KR. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr Opin Immunol 2002; 14(5): 569-575.
    • (2002) Curr Opin Immunol , vol.14 , Issue.5 , pp. 569-575
    • Brinkmann, V.1    Lynch, K.R.2
  • 30
    • 28044462458 scopus 로고    scopus 로고
    • FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors
    • Chiba K. FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors. Pharmacol Ther 2005; 108(3): 308-319.
    • (2005) Pharmacol Ther , vol.108 , Issue.3 , pp. 308-319
    • Chiba, K.1
  • 31
    • 77954898611 scopus 로고    scopus 로고
    • Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation
    • Jörns A, Rath KJ, Terbish T, et al. Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. Endocrinology 2010; 151(8): 3555-3565.
    • (2010) Endocrinology , vol.151 , Issue.8 , pp. 3555-3565
    • Jörns, A.1    Rath, K.J.2    Terbish, T.3
  • 32
    • 50249150303 scopus 로고    scopus 로고
    • FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice
    • Kendall MR, Hupfeld CJ. FTY720, a sphingosine-1-phosphate receptor modulator, reverses high-fat diet-induced weight gain, insulin resistance and adipose tissue inflammation in C57BL/6 mice. Diabetes Obes Metab 2008; 10(9): 802-805.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.9 , pp. 802-805
    • Kendall, M.R.1    Hupfeld, C.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.