Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells

Diabetologia

Volumn 52, Issue 10, 2009, Pages 2142-2150

  Wei, P ^a   Shi, M ^a   Barnum, S ^a   Cho, H ^a   Carlson, T ^a   Fraser, J D ^a  

^a PFIZER INC   (United States)

Author keywords

Apoptosis; Beta cell; Glucokinase activator; Proliferation

Indexed keywords

2 CYCLOHEXYL 1 (4 METHANESULFONYLPHENYL)CYCLOPROPANECARBOXYLIC ACID 2 THIAZOLYLAMIDE; BROXURIDINE; CASPASE 3; ENZYME ACTIVATOR; GKA 50; GLUCOKINASE; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN BAD; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL LOSS; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOKINASE; INSULIN-SECRETING CELLS; PYRIDINES; RATS; SULFONES; THIAZOLES;

EID: 69949123393     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1446-0     Document Type: Article

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