Muscle wasting in disease: Molecular mechanisms and promising therapies

Nature Reviews Drug Discovery

Volumn 14, Issue 1, 2014, Pages 58-74

  Cohen, Shenhav ^a   Nathan, James A ^b   Goldberg, Alfred L ^c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ANAMORELIN; BIMAGRUMAB; CLAZAKIZUMAB; ENOBOSARM; ETANERCEPT; GLUCOCORTICOID RECEPTOR; GSK 2849466; INFLIXIMAB; INTERLEUKIN 1; INTERLEUKIN 6; LGD 4033; LY 2495655; MAMMALIAN TARGET OF RAPAMYCIN; MT 102; MUSCLE RING FINGER 1 PROTEIN; MYOSTATIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PROTEIN KINASE B; SELECTIVE ANDROGEN RECEPTOR MODULATOR; SIRTUIN 1; SMAD2 PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN C; SUN 11031; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; MSTN PROTEIN, HUMAN;

AEROBIC METABOLISM; AUTOPHAGY; BED REST; CACHEXIA; CELL PROLIFERATION; DISEASE COURSE; DRUG EFFICACY; HUMAN; INSULIN RESISTANCE; MITOPHAGY; MOLECULAR DYNAMICS; MUSCLE ATROPHY; MUSCLE MASS; MUSCULAR DYSTROPHY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; QUALITY OF LIFE; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; MUSCLE FIBRIL; MUSCULAR ATROPHY; PATHOLOGY; PHYSIOLOGY; SEPSIS; WASTING SYNDROME;

ANIMALS; HUMANS; MUSCULAR ATROPHY; MYOFIBRILS; MYOSTATIN; QUALITY OF LIFE; SEPSIS; SIGNAL TRANSDUCTION; WASTING SYNDROME;

EID: 84925286847     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4467     Document Type: Review

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