MST1, a key player, in enhancing fast skeletal muscle atrophy

BMC Biology

Volumn 11, Issue , 2013, Pages

  Wei, Bin ^a   Dui, Wen ^a   Liu, Dong ^a   Xing, Yan ^a   Yuan, Zengqiang ^a   Ji, Guangju ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

Author keywords

FOXO3a; MST1; muscle atrophy

Indexed keywords

MAMMALIA; MUS;

FBXO32 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; MUSCLE PROTEIN; PROTEIN SERINE THREONINE KINASE; STK4 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL; ARTICLE; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; MUSCLE ATROPHY; NEWBORN; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; FORKHEAD TRANSCRIPTION FACTORS; MICE; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION, GENETIC; UP-REGULATION;

MLCS; MLOWN;

EID: 84873035233     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-11-12     Document Type: Article

References (53)

1. Tidball JG. Mechanical signal transduction in skeletal muscle growth and adaptation. J Appl Physiol 2005, 98:1900-1908. 10.1152/japplphysiol.01178.2004, 15829723.
2. Andersson DC, Betzenhauser MJ, Reiken S, Meli AC, Umanskaya A, Xie W, Shiomi T, Zalk R, Lacampagne A, Marks AR. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 2011, 14:196-207. 10.1016/j.cmet.2011.05.014, 21803290.
3. Mourtzakis M, Bedbrook M. Muscle atrophy in cancer: a role for nutrition and exercise. Appl Physiol Nutr Metab 2009, 34:950-956. 10.1139/H09-075, 19935858.
4. Penna F, Bonetto A, Muscaritoli M, Costamagna D, Minero VG, Bonelli G, Rossi Fanelli F, Baccino FM, Costelli P. Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?. Int J Cancer 2010, 127:1706-1717. 10.1002/ijc.25146, 20039316.
5. Carvalho RF, Castan EP, Coelho CA, Lopes FS, Almeida FL, Michelin A, de Souza RW, Araujo JP, Cicogna AC, Dal Pai-Silva M. Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy. J Mol Histol 2010, 41:81-87. 10.1007/s10735-010-9262-x, 20349269.
6. Martinez PF, Okoshi K, Zornoff LA, Carvalho RF, Oliveira Junior SA, Lima AR, Campos DH, Damatto RL, Padovani CR, Nogueira CR, Dal Pai-Silva M, Okoshi MP. Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors. Med Sci Monit 2010, 16:BR374-383.
7. Hulmi JJ, Silvennoinen M, Lehti M, Kivela R, Kainulainen H. Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy. Am J Physiol Endocrinol Metab 2012, 302:E307-315. 10.1152/ajpendo.00398.2011, 22068602.
8. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 2001, 3:1014-1019. 10.1038/ncb1101-1014, 11715023.
9. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci USA 2001, 98:14440-14445. 10.1073/pnas.251541198, 64700, 11717410.
10. Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL. During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol 2009, 185:1083-1095. 10.1083/jcb.200901052, 2711608, 19506036.
11. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, Poueymirou WT, Panaro FJ, Na E, Dharmarajan K, Pan ZQ, Valenzuela DM, DeChiara TM, Stitt TN, Yancopoulos GD, Glass DJ. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001, 294:1704-1708. 10.1126/science.1065874, 11679633.
12. Furuno K, Goodman MN, Goldberg AL. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. J Biol Chem 1990, 265:8550-8557.
13. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. FOXO transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004, 117:399-412. 10.1016/S0092-8674(04)00400-3, 15109499.
14. Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 2007, 6:472-483. 10.1016/j.cmet.2007.11.004, 18054316.
15. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 2007, 6:458-471. 10.1016/j.cmet.2007.11.001, 18054315.
16. Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell 2010, 143:35-45. 10.1016/j.cell.2010.09.004, 2982779, 20887891.
17. Reed SA, Senf SM, Cornwell EW, Kandarian SC, Judge AR. Inhibition of IkappaB kinase alpha (IKKalpha) or IKKbeta (IKKbeta) plus forkhead box O (FOXO) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun 2011, 405:491-496. 10.1016/j.bbrc.2011.01.059, 3056397, 21256828.
18. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell 2004, 119:285-298. 10.1016/j.cell.2004.09.027, 15479644.
19. Calnan DR, Brunet A. The FoxO code. Oncogene 2008, 27:2276-2288. 10.1038/onc.2008.21, 18391970.
20. van der Heide LP, Hoekman MF, Smidt MP. The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem J 2004, 380:297-309. 10.1042/BJ20040167, 1224192, 15005655.
21. Gordon SE, Lake JA, Westerkamp CM, Thomson DM. Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?. Exerc Sport Sci Rev 2008, 36:179-186. 10.1097/JES.0b013e3181877e13, 2659413, 18815486.
22. Nakashima K, Yakabe Y. AMPK activation stimulates myofibrillar protein degradation and expression of atrophy-related ubiquitin ligases by increasing FOXO transcription factors in C2C12 myotubes. Biosci Biotechnol Biochem 2007, 71:1650-1656. 10.1271/bbb.70057, 17617726.
23. Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Pledger JW, Chen J, Bai W. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem 2009, 284:13987-14000. 10.1074/jbc.M901758200, 2682847, 19321440.
24. Senf SM, Sandesara PB, Reed SA, Judge AR. p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle. Am J Physiol Cell Physiol 2011, 300:C1490-1501. 10.1152/ajpcell.00255.2010, 3118617, 21389279.
25. Bertaggia E, Coletto L, Sandri M. Posttranslational modifications control FoxO3 activity during denervation. Am J Physiol Cell Physiol 2012, 302:C587-596. 10.1152/ajpcell.00142.2011, 22094330.
26. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868. 10.1016/S0092-8674(00)80595-4, 10102273.
27. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 2004, 14:395-403. 10.1016/S1097-2765(04)00211-4, 15125842.
28. Obsilova V, Vecer J, Herman P, Pabianova A, Sulc M, Teisinger J, Boura E, Obsil T. 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4. Biochemistry 2005, 44:11608-11617. 10.1021/bi050618r, 16114898.
29. Xiao L, Chen D, Hu P, Wu J, Liu W, Zhao Y, Cao M, Fang Y, Bi W, Zheng Z, Ren J, Ji G, Wang Y, Yuan Z. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. J Neurosci 2011, 31:9611-9619. 10.1523/JNEUROSCI.0035-11.2011, 21715626.
30. Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006, 125:987-1001. 10.1016/j.cell.2006.03.046, 16751106.
31. Schinkmann K, Blenis J. Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. J Biol Chem 1997, 272:28695-28703. 10.1074/jbc.272.45.28695, 9353338.
32. Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM. MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway. Oncogene 2001, 20:6559-6569. 10.1038/sj.onc.1204818, 11641781.
33. Bi W, Xiao L, Jia Y, Wu J, Xie Q, Ren J, Ji G, Yuan Z. c-Jun N-terminal kinase enhances MST1-mediated pro-apoptotic signaling through phosphorylation at serine 82. J Biol Chem 2010, 285:6259-6264. 10.1074/jbc.M109.038570, 2825421, 20028971.
34. Yuan Z, Kim D, Shu S, Wu J, Guo J, Xiao L, Kaneko S, Coppola D, Cheng JQ. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem 2010, 285:3815-3824. 10.1074/jbc.M109.059675, 2823523, 19940129.
35. Graves JD, Draves KE, Gotoh Y, Krebs EG, Clark EA. Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. J Biol Chem 2001, 276:14909-14915. 10.1074/jbc.M010905200, 11278782.
36. Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, Wright M, Chernoff J, Clark EA, Krebs EG. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 1998, 17:2224-2234. 10.1093/emboj/17.8.2224, 1170567, 9545236.
37. Zhao B, Li L, Guan KL. Hippo signaling at a glance. J Cell Sci 2010, 123:4001-4006. 10.1242/jcs.069070, 2987436, 21084559.
38. Watt KI, Judson R, Medlow P, Reid K, Kurth TB, Burniston JG, Ratkevicius A, De Bari C, Wackerhage H. Yap is a novel regulator of C2C12 myogenesis. Biochem Biophys Res Commun 2010, 393:619-624. 10.1016/j.bbrc.2010.02.034, 20153295.
39. You B, Yan G, Zhang Z, Yan L, Li J, Ge Q, Jin JP, Sun J. Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1. Biochem J 2009, 418:93-101. 10.1042/BJ20081340, 2754779, 18986304.
40. Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M, Sadoshima J. Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction. Circ Res 2007, 100:1344-1352. 10.1161/01.RES.0000265846.23485.7a, 17395874.
41. Fernando P, Kelly JF, Balazsi K, Slack RS, Megeney LA. Caspase 3 activity is required for skeletal muscle differentiation. Proc Natl Acad Sci USA 2002, 99:11025-11030. 10.1073/pnas.162172899, 123204, 12177420.
42. Agbulut O, Noirez P, Beaumont F, Butler-Browne G. Myosin heavy chain isoforms in postnatal muscle development of mice. Biol Cell 2003, 95:399-406. 10.1016/S0248-4900(03)00087-X, 14519557.
43. Schiaffino S, Reggiani C. Fiber types in mammalian skeletal muscles. Physiol Rev 2011, 91:1447-1531. 10.1152/physrev.00031.2010, 22013216.
44. Dong Y, Du X, Ye J, Han M, Xu T, Zhuang Y, Tao W. A cell-intrinsic role for Mst1 in regulating thymocyte egress. J Immunol 2009, 183:3865-3872. 10.4049/jimmunol.0900678, 19692642.
45. Sandri M. Autophagy in skeletal muscle. FEBS Lett 2010, 584:1411-1416. 10.1016/j.febslet.2010.01.056, 20132819.
46. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19:5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
47. He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem 2003, 278:29278-29287. 10.1074/jbc.M303800200, 12740394.
48. Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007, 3:542-545.
49. Sandri M. Signaling in muscle atrophy and hypertrophy. Physiology (Bethesda) 2008, 23:160-170.
50. Reed SA, Sandesara PB, Senf SM, Judge AR. Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. FASEB J 2012, 26:987-1000. 10.1096/fj.11-189977, 22102632.
51. Xie Q, Hao Y, Tao L, Peng S, Rao C, Chen H, You H, Dong MQ, Yuan Z. Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep 2012, 13:371-377. 10.1038/embor.2012.25, 22402663.
52. Feng HZ, Wei B, Jin JP. Deletion of a genomic segment containing the cardiac troponin I gene knocks down expression of the slow troponin T gene and impairs fatigue tolerance of diaphragm muscle. J Biol Chem 2009, 284:31798-31806. 10.1074/jbc.M109.020826, 2797250, 19797054.
53. Xie Q, Chen J, Yuan Z. Post-translational regulation of FOXO. Acta Biochim Biophys Sin (Shanghai) 2012, 44:897-901.