The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

International Journal of Obesity

Volumn 33, Issue 11, 2009, Pages 1265-1273

  Akpan, I ^a,b   Goncalves, M D ^a,b   Dhir, R ^a,b   Yin, X ^a,b   Pistilli, E E ^a   Bogdanovich, S ^a   Khurana, T S ^a   Ucran, J ^c   Lachey, J ^c   Ahima, R S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Acceleron Pharma   (United States)

Author keywords

Activin receptor; Glucose; Insulin; Mice; Muscle; Myostatin

Indexed keywords

ACTIVIN RECEPTOR 2; ADIPONECTIN; GLUCOSE; HYBRID PROTEIN; INSULIN; RAP 031; SOLUBLE ACTIVIN RECEPTOR 2B; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ACTIVIN RECEPTOR TYPE II-B; MYOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FAT CONTENT; GLUCONEOGENESIS; GLUCOSE TRANSPORT; GRIP STRENGTH; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; MUSCLE CONTRACTION; MUSCLE MASS; NONHUMAN; OBESITY; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLUBILITY;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; CASE-CONTROL STUDIES; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; MYOSTATIN; OBESITY; SIGNAL TRANSDUCTION; SOLUBILITY;

MUS;

EID: 70450285198     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.162     Document Type: Article

References (38)

1. McPherron AC, Lee SJ. Double muscling in cattle due to mutations in the myostatin gene. Proc Natl Acad Sci USA 1997; 94: 12457-12461.
2. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature 1997; 387: 83-90.
3. Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG et al. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genet 2007; 3: e79.
4. Schuelke M, Wagner KR, Stolz LE, Hubner C, Riebel T, Komen W et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N Engl J Med 2004; 350: 2682-2688.
5. Bogdanovich S, Krag TO, Barton ER, Morris LD, Whittemore LA, Ahima RS et al. Functional improvement of dystrophic muscle by myostatin blockade. Nature 2002; 420: 418-421.
6. Bogdanovich S, Perkins KJ, Krag TO, Whittemore LA, Khurana TS. Myostatin propeptide-mediated amelioration of dystrophic pathophysiology. FASEB J 2005; 19: 543-549.
7. Suzuki ST, Zhao B, Yang J. Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-alpha, and PPAR-gamma expressions. Biochem Biophys Res Commun 2008; 369: 767-773.
8. Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C et al. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci USA 2008; 105: 4318-4322.
9. Artaza JN, Bhasin S, Magee TR, Reisz-Porszasz S, Shen R, Groome NP et al. Myostatin inhibits myogenesis and promotes adipo-genesis in C3H 10T(1/2) mesenchymal multipotent cells. Endocrinology 2005; 146: 3547-3557.
10. Feldman BJ, Streeper RS, Farese Jr RV, Yamamoto KR. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci USA 2006; 103: 15675-15680.
11. Kim HS, Liang L, Dean RG, Hausman DB, Hartzell DL, Baile CA. Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Biochem Biophys Res Commun 2001; 281: 902-906.
12. Rebbapragada A, Benchabane H, Wrana JL, Celeste AJ, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol 2003; 23: 7230-7242.
13. Allen DL, Cleary AS, Speaker KJ, Lindsay SF, Uyenishi J, Reed JM et al. Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab 2008; 294: E918-E927.
14. Hittel DS, Berggren JR, Shearer J, Boyle K, Houmard JA. Increased secretion and expression of myostatin in skeletal muscle from extremely obese women. Diabetes 2009; 58: 30-38.
15. Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN et al. Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci USA 2005; 102: 18117-18122.
16. Wilkes JJ, Lloyd DJ, Gekakis N. A loss-of-function mutation in myostatin reduces TNF\{alpha\} production and protects liver. Diabetes 2009; 58: 1133-1143.
17. McPherron AC, Lee SJ. Suppression of body fat accumulation in myostatin-deficient mice. J Clin Invest 2002; 109: 595-601.
18. Zhao B, Wall RJ, Yang J. Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance. Biochem Biophys Res Commun 2005; 337: 248-255.
19. Morrison BM, Lachey JL, Warsing LC, Ting BL, Pullen AE, Underwood KW et al. A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 2009; 217: 258-268.
20. Takahashi N, Patel HR, Qi Y, Dushay J, Ahima RS. Divergent effects of leptin in mice susceptible or resistant to obesity. Horm Metab Res 2002; 34: 691-697.
21. Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ et al. Inhibition of ADRP prevents diet-induced insulin resistance. Am J Physiol Gastrointest Liver Physiol 2008; 295: G621-G628.
22. Singhal NS, Lazar MA, Ahima RS. Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci 2007; 27: 12924-12932.
23. Moens P, Baatsen PH, Marechal G. Increased susceptibility of EDL muscles from mdx mice to damage induced by contractions with stretch. J Muscle Res Cell Motil 1993; 14: 446-451.
24. Petrof BJ, Shrager JB, Stedman HH, Kelly AM, Sweeney HL. Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proc Natl Acad Sci USA 1993; 90: 3710-3714.
25. Mendias CL, Marcin JE, Calerdon DR, Faulkner JA. Contractile properties of EDL and soleus muscles of myostatin-deficient mice. J Appl Physiol 2006; 101: 898-905.
26. Leibel RL, Hirsch J. Metabolic characterization of obesity. Ann Intern Med 1985; 103: 1000-1002.
27. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000; 106: 473-481.
28. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
29. Galgani JE, Moro C, Ravussin E. Metabolic flexibility and insulin resistance. Am J Physiol Endocrinol Metab 2008; 295: E1009-E1017.
30. Moro C, Bajpeyi S, Smith SR. Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am J Physiol Endocrinol Metab 2008; 294: E203-E213.
31. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008; 88: 1379-1406.
32. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN et al. Induction of cachexia in mice by systemically administered myostatin. Science 2002; 296: 1486-1488.
33. Stolz LE, Li D, Qadri A, Jalenak M, Klaman LD, Tobin JF. Administration of myostatin does not alter fat mass in adult mice. Diabetes Obes Metab 2008; 10: 135-142.
34. Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005; 26: 439-451.
35. Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J et al. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab 2008; 7: 159-172.
36. Ouchi N, Oshima Y, Ohashi K, Higuchi A, Ikegami C, Izumiya Y et al. Follistatin-like 1, a secreted muscle protein, promotes endothelial cell function and revascularization in ischemic tissue through a nitric-oxide synthase-dependent mechanism. J Biol Chem 2008; 283: 32802-32811.
37. Sartori R, Milan G, Patron M, Mammucari C, Blaauw B, Abraham R et al. Smad2 and 3 transcription factors control muscle mass in adulthood. Am J Physiol Cell Physiol 2009; 296: C1248-C1257.
38. Trendelenburg AU, Meyer A, Rohner D, Boyle J, Hatakeyama S, Glass DJ. Myostatin reduces Akt/TORC1/p70S6 K signaling, inhibiting myoblast differentiation and myotube size. Am J Physiol Cell Physiol 2009; 296: C1258-C1270