Tumor necrosis factor-α regulates distinct molecular pathways and gene networks in cultured skeletal muscle cells

PLoS ONE

Volumn 5, Issue 10, 2010, Pages

  Bhatnagar, Shephali ^a   Panguluri, Siva K ^a   Gupta, Sanjay K ^a   Dahiya, Saurabh ^a   Lundy, Robert F ^a   Kumar, Ashok ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 RECEPTOR; PROTEASOME; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE REGULATORY NETWORK; LIVER FIBROSIS; MICROARRAY ANALYSIS; MOUSE; MUSCLE ATROPHY; MUSCLE CELL; MYOTUBE; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; DNA MICROARRAY; DOWN REGULATION; GENE EXPRESSION PROFILING; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VALIDATION STUDY;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; MICE; MUSCLE, SKELETAL; NF-KAPPA B; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 78149443851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013262     Document Type: Article

References (62)

1. Adams V, Doring C, Schuler G (2008) Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. Front Biosci 13: 302-311.
2. Eikermann M, Koch G, Gerwig M, Ochterbeck C, Beiderlinden M, et al. (2006) Muscle force and fatigue in patients with sepsis and multiorgan failure. Intensive Care Med 32: 251-259.
3. Lang CH, Frost RA, Vary TC (2007) Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab 293: E453-459.
4. Filippatos GS, Anker SD, Kremastinos DT (2005) Pathophysiology of peripheral muscle wasting in cardiac cachexia. Curr Opin Clin Nutr Metab Care 8: 249-254.
5. Li YP, Reid MB (2001) Effect of tumor necrosis factor-alpha on skeletal muscle metabolism. Curr Opin Rheumatol 13: 483-487.
6. Spate U, Schulze PC (2004) Proinflammatory cytokines and skeletal muscle. Curr Opin Clin Nutr Metab Care 7: 265-269.
7. Aggarwal BB (2003) Signalling pathways of the TNF superfamily: a doubleedged sword. Nat Rev Immunol 3: 745-756.
8. Baud V, Karin M (2001) Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 11: 372-377.
9. Srivastava AK, Qin X, Wedhas N, Arnush M, Linkhart TA, et al. (2007) Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway. J Biol Chem 282: 35113-35124.
10. Li H, Malhotra S, Kumar A (2008) Nuclear factor-kappa B signaling in skeletal muscle atrophy. J Mol Med 86: 1113-1126.
11. Acharyya S, Guttridge DC (2007) Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res 13: 1356-1361.
12. Kumar A, Takada Y, Boriek AM, Aggarwal BB (2004) Nuclear factor-kappaB: its role in health and disease. J Mol Med 82: 434-448.
13. Cai D, Frantz JD, Tawa NE, Jr., Melendez PA, Oh BC, et al. (2004) IKKbeta/ NF-kappaB activation causes severe muscle wasting in mice. Cell 119: 285-298.
14. Hunter RB, Kandarian SC (2004) Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J Clin Invest 114: 1504-1511.
15. Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, et al. (2006) Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration. J Clin Invest 116: 2945-2954.
16. Dogra C, Changotra H, Wedhas N, Qin X, Wergedal JE, et al. (2007) TNFrelated weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J 21: 1857-1869.
17. Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB (1998) Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J 12: 871-880.
18. Guttridge DC, Mayo MW, Madrid LV, Wang CY, Baldwin AS Jr. (2000) NFkappaB- induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science 289: 2363-2366.
19. Langen RC, Schols AM, Kelders MC, Wouters EF, Janssen-Heininger YM (2001) Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J 15: 1169-1180.
20. Langen RC, Van Der Velden JL, Schols AM, Kelders MC, Wouters EF, et al. (2004) Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J 18: 227-237.
21. Tisdale M (1997) Biology of cachexia. J Natl Cancer Inst 89: 1763-1773.
22. Spiegelman BM, Hotamisligil GS (1993) Through thick and thin: Wasting, obesity, and TNF[alpha]. Cell 73: 625-627.
23. Mittal A, Bhatnagar S, Kumar A, Lach-Trifilieff E, Wauters S, et al. (2010) The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol 188: 833-849.
24. Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, et al. (2001) Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708.
25. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL (2001) Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A 98: 14440-14445.
26. Stevenson EJ, Giresi PG, Koncarevic A, Kandarian SC (2003) Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle. J Physiol 551: 33-48.
27. Giresi PG, Stevenson EJ, Theilhaber J, Koncarevic A, Parkington J, et al. (2005) Identification of a molecular signature of sarcopenia. Physiol Genomics 21: 253-263.
28. Panguluri SK, Bhatnagar S, Kumar A, McCarthy JJ, Srivastava AK, et al. (2010) Genomic profiling of messenger RNAs and microRNAs reveals potential mechanisms of TWEAK-induced skeletal muscle wasting in mice. PLoS One 5: e8760.
29. Blau HM, Chiu CP, Webster C (1983) Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell 32: 1171-1180.
30. Li YP, Lecker SH, Chen Y, Waddell ID, Goldberg AL, et al. (2003) TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J 17: 1048-1057.
31. Ladner KJ, Caligiuri MA, Guttridge DC (2003) Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem 278: 2294-2303.
32. Li H, Mittal A, Paul PK, Kumar M, Srivastava DS, et al. (2008) Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase-9 production (MMP-9) in skeletal muscle through the activation of nuclear factorkappa B-inducing kinase and p38 mitogen-activated protein kinase: A potential role of MMP-9 in myopathy. J Biol Chem 284: 4439-4450.
33. Li H, Mittal A, Makonchuk DY, Bhatnagar S, Kumar A (2009) Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy. Hum Mol Genet 18: 2584-2598.
34. Mihatsch K, Nestler M, Saluz HP, Henke A, Munder T (2009) Proapoptotic protein Siva binds to the muscle protein telethonin in cardiomyocytes during coxsackieviral infection. Cardiovasc Res 81: 108-115.
35. MacEwan DJ (2002) TNF receptor subtype signalling: differences and cellular consequences. Cell Signal 14: 477-492.
36. Bertazza L, Mocellin S (2008) Tumor necrosis factor (TNF) biology and cell death. Front Biosci 13: 2736-2743.
37. Coletti D, Moresi V, Adamo S, Molinaro M, Sassoon D (2005) Tumor necrosis factor-alpha gene transfer induces cachexia and inhibits muscle regeneration. Genesis 43: 120-128.
38. Coletti D, Yang E, Marazzi G, Sassoon D (2002) TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways. EMBO J 21: 631-642.
39. De Paepe B, Creus KK, De Bleecker JL (2007) Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses. Ann N Y Acad Sci 1109: 441-453.
40. Tessier PA, Naccache PH, Clark-Lewis I, Gladue RP, Neote KS, et al. (1997) Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. J Immunol 159: 3595-3602.
41. Vieira SM, Lemos HP, Grespan R, Napimoga MH, Dal-Secco D, et al. (2009) A crucial role for TNF-alpha in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/ CXCL5. Br J Pharmacol 158: 779-789.
42. Do M-S, Jeong H-S, Choi B-H, Hunter L, Langley S, et al. (2006) Inflammatory Gene Expression Patterns Revealed by DNA Microarray Analysis in TNF-Î6- treated SGBS Human Adipocytes. Yonsei Med J 47: 729-736.
43. Febbraio MA, Pedersen BK (2005) Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ? Exercise and Sport Sciences Reviews 33: 114-119.
44. Qin B, Dawson H, Anderson RA (2010) Elevation of tumor necrosis factor- {alpha} induces the overproduction of postprandial intestinal apolipoprotein B48-containing very low-density lipoprotein particles: evidence for related gene expression of inflammatory, insulin and lipoprotein signaling in enterocytes. Exp Biol Med 235: 199-205.
45. Zhang L, Du J, Hu Z, Han G, Delafontaine P, et al. (2009) IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol 20: 604-612.
46. van Rooij E, Liu N, Olson EN (2008) MicroRNAs flex their muscles. Trends Genet 24: 159-166.
47. Dogra C, Changotra H, Mohan S, Kumar A (2006) Tumor necrosis factor-like weak inducer of apoptosis inhibits skeletal myogenesis through sustained activation of nuclear factor-kappaB and degradation of MyoD protein. J Biol Chem 281: 10327-10336.
48. Muller FL, Song W, Jang YC, Liu Y, Sabia M, et al. (2007) Denervationinduced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol 293: R1159-1168.
49. Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, et al. (2008) Skeletal muscle is a primary target of SOD1G93A-mediated toxicity. Cell Metab 8: 425-436.
50. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284: 770-776.
51. Johansen KM, Fehon RG, Artavanis-Tsakonas S (1989) The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J Cell Biol 109: 2427-2440.
52. Struhl G, Greenwald I (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398: 522-525.
53. Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, et al. (1999) Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem 274: 36801-36807.
54. Guan E, Wang J, Laborda J, Norcross M, Baeuerle PA, et al. (1996) T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells. J Exp Med 183: 2025-2032.
55. Wang J, Shelly L, Miele L, Boykins R, Norcross MA, et al. (2001) Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain. J Immunol 167: 289-295.
56. DiMauro S, Miranda AF, Khan S, Gitlin K, Friedman R (1981) Human muscle phosphoglycerate mutase deficiency: newly discovered metabolic myopathy. Science 212: 1277-1279.
57. Bonizzi G, Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25: 280-288.
58. Hayden MS, Ghosh S (2004) Signaling to NF-kappaB. Genes Dev 18: 2195-2224.
59. Maecker H, Varfolomeev E, Kischkel F, Lawrence D, LeBlanc H, et al. (2005) TWEAK attenuates the transition from innate to adaptive immunity. Cell 123: 931-944.
60. Romanello V, Guadagnin E, Gomes L, Roder I, Sandri C, et al. (2010) Mitochondrial fission and remodelling contributes to muscle atrophy. EMBO J 29: 1774-1785.
61. Bhatnagar S, Kumar A (2010) Therapeutic targeting of signaling pathways in muscular dystrophy. J Mol Med 88: 155-166.
62. Dogra C, Hall SL, Wedhas N, Linkhart TA, Kumar A (2007) Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAKindependent functions of Fn14 during myogenesis. J Biol Chem 282: 15000-15010.