Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

Nature Chemical Biology

Volumn 9, Issue 9, 2013, Pages 548-559

  Magnaghi, Paola ^a   D'Alessio, Roberto ^a   Valsasina, Barbara ^a   Avanzi, Nilla ^a   Rizzi, Simona ^a   Asa, Daniela ^a   Gasparri, Fabio ^a   Cozzi, Liviana ^a   Cucchi, Ulisse ^a   Orrenius, Christian ^a   Polucci, Paolo ^a   Ballinari, Dario ^a   Perrera, Claudia ^a   Leone, Antonella ^a   Cervi, Giovanni ^a   Casale, Elena ^a   Xiao, Yang ^b   Wong, Chihunt ^b   Anderson, Daniel J ^b   Galvani, Arturo ^a   Donati, Daniele ^a   O'Brien, Tom ^b   Jackson, Peter K ^b,c   Isacchi, Antonella ^a   more..

^a Oncology Business Unit   (Italy)

^b GENENTECH INC   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASE INHIBITOR; AMP PNP; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CYSTEINE; NMS 249; NMS 485A; NMS 694; NMS 859; NMS 862; NMS 873; SURVIVIN; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN;

ALLOSTERIC INHIBITION; ALLOSTERISM; ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; BIOLOGICAL ACTIVITY; CANCER CELL; CANCER CELL CULTURE; CELL DEATH; CELL STRAIN HCT116; CONTROLLED STUDY; COVALENT INHIBITION; DRUG BINDING SITE; DRUG INHIBITION; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; GENE SILENCING; HELA CELL; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; INSECT CELL CULTURE; MUTAGENESIS; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; STRUCTURE ANALYSIS; TRANSIENT TRANSFECTION; UNFOLDED PROTEIN RESPONSE; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; ALLOSTERIC REGULATION; ANTINEOPLASTIC AGENTS; CELL CYCLE PROTEINS; CELL DEATH; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883196231     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1313     Document Type: Article

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