Glucocorticoid antagonist RU38486 fails to block acid-induced muscle wasting in vivo or in vitro

Nephrology Dialysis Transplantation

Volumn 18, Issue 8, 2003, Pages 1475-1484

  Pickering, Warren P ^a   Baker, Frease E ^a   Brown, Jeremy ^a   Butler, Heather L ^a   Govindji, Sheena ^a   Parsons, Julie M ^a   Pawluczyk, Izabella Z A ^a   Walls, John ^a   Bevington, Alan ^a  

^a LEICESTER GENERAL HOSPITAL   (United Kingdom)

Author keywords

Glucocorticoid; Insulin like growth factor I; Metabolic acidosis; Protein degradation; RU38486; Skeletal muscle

Indexed keywords

DEXAMETHASONE; DRUG VEHICLE; GLUCOCORTICOID; GLUCOCORTICOID ANTAGONIST; HYDROCHLORIC ACID; MIFEPRISTONE; MUSCLE PROTEIN; SOMATOMEDIN C;

ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; GASTROCNEMIUS MUSCLE; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLIC ACIDOSIS; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; RAT STRAIN; SKELETAL MUSCLE; UREMIA; WEIGHT GAIN; WEIGHT REDUCTION;

ACIDOSIS; ANIMALS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HORMONE ANTAGONISTS; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIFEPRISTONE; MUSCLE, SKELETAL; RANDOM ALLOCATION; RATS; RECEPTORS, GLUCOCORTICOID;

EID: 0042594626     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg203     Document Type: Article

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