IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

American Journal of Physiology - Endocrinology and Metabolism

Volumn 287, Issue 4 50-4, 2004, Pages

  Sacheck, Jennifer M ^a   Ohtsuka, Akira ^b   McLary, S Christine ^a   Goldberg, Alfred L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

3 methylhistidine; Glucocorticoids; Insulin; Phosphatidylinositol 3 kinase Akt pathway

Indexed keywords

3 METHYLHISTIDINE; CALCINEURIN; CELL PROTEIN; DEXAMETHASONE; GLUCOCORTICOID; INSULIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MUSCLE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; TRANSCRIPTION FACTOR NFAT; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE REPRESSION; GENETIC TRANSCRIPTION; GROWTH STIMULATION; MOUSE; MUSCLE ATROPHY; MUSCLE GROWTH; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; RNA DEGRADATION; RNA SYNTHESIS;

NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, NORTHERN; CELLS, CULTURED; DEXAMETHASONE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; METHYLHISTIDINES; MUSCLE FIBERS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOBLASTS; MYOFIBRILS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKP CULLIN F-BOX PROTEIN LIGASES; STIMULATION, CHEMICAL; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 4544293878     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00073.2004     Document Type: Article

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