메뉴 건너뛰기




Volumn 21, Issue , 2015, Pages 740-748

Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: A meta-analysis based on 51 case-control studies

Author keywords

10 Methylenetetrahydrofolate Reductase (FADH2); 5; Meta Analysis; Precursor Cell Lymphoblastic Leukemia Lymphoma

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

EID: 84924729700     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.892835     Document Type: Article
Times cited : (18)

References (83)
  • 1
    • 84878341989 scopus 로고    scopus 로고
    • Acute lymphoblastic leukaemia
    • Inaba H, Greaves M, Mullighan CG: Acute lymphoblastic leukaemia. Lancet, 2013; 381: 1943–55.
    • (2013) Lancet , vol.381 , pp. 1943-1955
    • Inaba, H.1    Greaves, M.2    Mullighan, C.G.3
  • 2
    • 84859784342 scopus 로고    scopus 로고
    • Perspectives on the causes of childhood leukemia
    • Wiemels J: Perspectives on the causes of childhood leukemia. Chem Biol Interact, 2012; 196: 59–67.
    • (2012) Chem Biol Interact , vol.196 , pp. 59-67
    • Wiemels, J.1
  • 3
    • 77952884769 scopus 로고    scopus 로고
    • Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
    • Sherborne AL, Hosking FJ, Prasad RB et al: Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet, 2010; 42: 492–94.
    • (2010) Nat Genet , vol.42 , pp. 492-494
    • Sherborne, A.L.1    Hosking, F.J.2    Prasad, R.B.3
  • 4
    • 77950349468 scopus 로고    scopus 로고
    • Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhoo
    • Prasad RB, Hosking FJ, Vijayakrishnan J et al: Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. Blood, 2010; 115: 1765–67.
    • (2010) Blood , vol.115 , pp. 1765-1767
    • Prasad, R.B.1    Hosking, F.J.2    Vijayakrishnan, J.3
  • 5
    • 69349091330 scopus 로고    scopus 로고
    • Germline genomic variants associated with childhood acute lymphoblastic leukemia
    • Trevino LR, Yang W, French D et al: Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet, 2009; 41: 1001–5.
    • (2009) Nat Genet , vol.41 , pp. 1001-1005
    • Trevino, L.R.1    Yang, W.2    French, D.3
  • 6
    • 4444363632 scopus 로고    scopus 로고
    • Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (Strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    • Narayanan S, McConnell J, Little J et al: Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Cancer Epidemiol Biomarkers Prev, 2004; 13: 1436–43.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 1436-1443
    • Narayanan, S.1    McConnell, J.2    Little, J.3
  • 7
    • 0033607241 scopus 로고    scopus 로고
    • Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults
    • Skibola CF, Smith MT, Kane E et al: Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA, 1999; 96: 12810–15.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12810-12815
    • Skibola, C.F.1    Smith, M.T.2    Kane, E.3
  • 8
    • 2442628250 scopus 로고    scopus 로고
    • DNA methylation profiles of lymphoid and hematopoietic malignancies
    • Takahashi T, Shivapurkar N, Reddy J et al: DNA methylation profiles of lymphoid and hematopoietic malignancies. Clin Cancer Res, 2004; 10: 2928–35.
    • (2004) Clin Cancer Res , vol.10 , pp. 2928-2935
    • Takahashi, T.1    Shivapurkar, N.2    Reddy, J.3
  • 9
    • 33645215136 scopus 로고    scopus 로고
    • Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia
    • Agirre X, Roman-Gomez J, Vazquez I et al: Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Int J Cancer, 2006; 118: 1945–53.
    • (2006) Int J Cancer , vol.118 , pp. 1945-1953
    • Agirre, X.1    Roman-Gomez, J.2    Vazquez, I.3
  • 10
    • 77957970697 scopus 로고    scopus 로고
    • DNA methylation profiling in acute myeloid leukemia: From recent technological advances to biological and clinical insights
    • Claus R, Plass C, Armstrong SA, Bullinger L: DNA methylation profiling in acute myeloid leukemia: from recent technological advances to biological and clinical insights. Future Oncol, 2010; 6: 1415–31.
    • (2010) Future Oncol , vol.6 , pp. 1415-1431
    • Claus, R.1    Plass, C.2    Armstrong, S.A.3    Bullinger, L.4
  • 11
    • 84863497603 scopus 로고    scopus 로고
    • A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies
    • McGovern AP, Powell BE, Chevassut TJ: A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies. J Theor Biol, 2012; 310: 14–20.
    • (2012) J Theor Biol , vol.310 , pp. 14-20
    • McGovern, A.P.1    Powell, B.E.2    Chevassut, T.J.3
  • 12
    • 84880318248 scopus 로고    scopus 로고
    • Landmark analysis of DNMT3A mutations in hematological malignancies
    • Roller A, Grossmann V, Bacher U et al: Landmark analysis of DNMT3A mutations in hematological malignancies. Leukemia, 2013; 27: 1573–78.
    • (2013) Leukemia , vol.27 , pp. 1573-1578
    • Roller, A.1    Grossmann, V.2    Bacher, U.3
  • 13
    • 84895810190 scopus 로고    scopus 로고
    • The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
    • Solary E, Bernard OA, Tefferi A et al: The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases. Leukemia, 2014; 28: 485–96.
    • (2014) Leukemia , vol.28 , pp. 485-496
    • Solary, E.1    Bernard, O.A.2    Tefferi, A.3
  • 14
    • 0031904465 scopus 로고    scopus 로고
    • Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
    • Goyette P, Pai A, Milos R et al: Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome, 1998; 9: 652–56.
    • (1998) Mamm Genome , vol.9 , pp. 652-656
    • Goyette, P.1    Pai, A.2    Milos, R.3
  • 15
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995; 10: 111–13.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 16
    • 0034808335 scopus 로고    scopus 로고
    • A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk
    • Lievers KJ, Boers GH, Verhoef P et al: A second common variant in the methylenetetrahydrofolate reductase (MTHFR) gene and its relationship to MTHFR enzyme activity, homocysteine, and cardiovascular disease risk. J Mol Med (Berl), 2001; 79: 522–28.
    • (2001) J Mol Med (Berl) , vol.79 , pp. 522-528
    • Lievers, K.J.1    Boers, G.H.2    Verhoef, P.3
  • 17
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B et al: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab, 1998; 64: 169–72.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3
  • 18
    • 77949615888 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population
    • Tong N, Fang Y, Li J et al: Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population. Cancer Sci, 2010; 101: 782–86.
    • (2010) Cancer Sci , vol.101 , pp. 782-786
    • Tong, N.1    Fang, Y.2    Li, J.3
  • 19
    • 77952749179 scopus 로고    scopus 로고
    • Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children
    • Damnjanovic T, Milicevic R, Novkovic T et al: Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children. J Pediatr Hematol Oncol, 2010; 32: e148–e150.
    • (2010) J Pediatr Hematol Oncol , vol.32
    • Damnjanovic, T.1    Milicevic, R.2    Novkovic, T.3
  • 20
    • 33745778445 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism: Association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients
    • Chatzidakis K, Goulas A, Athanassiadou-Piperopoulou F et al: Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients. Pediatr Blood Cancer, 2006; 47: 147–51.
    • (2006) Pediatr Blood Cancer , vol.47 , pp. 147-151
    • Chatzidakis, K.1    Goulas, A.2    Athanassiadou-Piperopoulou, F.3
  • 21
    • 0035672957 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia
    • Franco RF, Simoes BP, Tone LG et al: The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol, 2001; 115: 616–18.
    • (2001) Br J Haematol , vol.115 , pp. 616-618
    • Franco, R.F.1    Simoes, B.P.2    Tone, L.G.3
  • 22
    • 84862496495 scopus 로고    scopus 로고
    • Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India
    • Nikbakht M, MalekZadeh K, Kumar Jha A et al: Polymorphisms of MTHFR and MTR genes are not related to susceptibility to childhood ALL in North India. Exp Oncol, 2012; 34: 43–48.
    • (2012) Exp Oncol , vol.34 , pp. 43-48
    • Nikbakht, M.1    Malekzadeh, K.2    Kumar Jha, A.3
  • 23
    • 84858824815 scopus 로고    scopus 로고
    • Lack of association between MTHFR C677T and A1298C polymorphisms and risk of childhood acute lymphoblastic leukemia in the Kurdish population from Western Iran
    • Azhar MR, Rahimi Z, Vaisi-Raygani A et al: Lack of association between MTHFR C677T and A1298C polymorphisms and risk of childhood acute lymphoblastic leukemia in the Kurdish population from Western Iran. Genet Test Mol Biomarkers, 2012; 16: 198–202.
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 198-202
    • Azhar, M.R.1    Rahimi, Z.2    Vaisi-Raygani, A.3
  • 24
    • 79951994081 scopus 로고    scopus 로고
    • The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia
    • Karathanasis NV, Stiakaki E, Goulielmos GN, Kalmanti M: The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia. Genet Test Mol Biomarkers, 2011; 15: 5–10.
    • (2011) Genet Test Mol Biomarkers , vol.15 , pp. 5-10
    • Karathanasis, N.V.1    Stiakaki, E.2    Goulielmos, G.N.3    Kalmanti, M.4
  • 25
    • 75749092993 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children
    • Sadananda Adiga MN, Chandy S, Ramachandra N et al: Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children. Indian J Cancer, 2010; 47: 40–45.
    • (2010) Indian J Cancer , vol.47 , pp. 40-45
    • Sadananda Adiga, M.N.1    Chandy, S.2    Ramachandra, N.3
  • 26
    • 77952611948 scopus 로고    scopus 로고
    • Genetic variation in the folate metabolic pathway and risk of childhood leukemia
    • Lightfoot TJ, Johnston WT, Painter D et al: Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood, 2010; 115: 3923–29.
    • (2010) Blood , vol.115 , pp. 3923-3929
    • Lightfoot, T.J.1    Johnston, W.T.2    Painter, D.3
  • 27
    • 84872863550 scopus 로고    scopus 로고
    • Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia
    • Silva RM, Fontes AC, Silva KA et al: Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. Genet Test Mol Biomarkers, 2013; 17: 147–52.
    • (2013) Genet Test Mol Biomarkers , vol.17 , pp. 147-152
    • Silva, R.M.1    Fontes, A.C.2    Silva, K.A.3
  • 28
    • 84858798304 scopus 로고    scopus 로고
    • Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies
    • Zintzaras E, Doxani C, Rodopoulou P et al: Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies. Cancer Epidemiol, 2012; 36: 169–76.
    • (2012) Cancer Epidemiol , vol.36 , pp. 169-176
    • Zintzaras, E.1    Doxani, C.2    Rodopoulou, P.3
  • 29
    • 84856812366 scopus 로고    scopus 로고
    • A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children
    • Yan J, Yin M, Dreyer ZE et al: A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer, 2012; 58: 513–18.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 513-518
    • Yan, J.1    Yin, M.2    Dreyer, Z.E.3
  • 30
    • 84865620566 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies
    • Wang H, Wang J, Zhao L et al: Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies. BMC Med Genet, 2012; 13: 77.
    • (2012) BMC Med Genet , vol.13
    • Wang, H.1    Wang, J.2    Zhao, L.3
  • 31
    • 84869404521 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: A meta-analysis
    • Wang H, Meng L, Zhao L et al: Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: a meta-analysis. Genet Test Mol Biomarkers, 2012; 16: 1401–7.
    • (2012) Genet Test Mol Biomarkers , vol.16 , pp. 1401-1407
    • Wang, H.1    Meng, L.2    Zhao, L.3
  • 32
    • 80053212404 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis based on 28 case-control studies
    • Tong N, Sheng X, Wang M et al: Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis based on 28 case-control studies. Leuk Lymphoma, 2011; 52: 1949–60.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1949-1960
    • Tong, N.1    Sheng, X.2    Wang, M.3
  • 33
    • 78149357320 scopus 로고    scopus 로고
    • MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-analysis
    • Wang J, Zhan P, Chen B et al: MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Res, 2010; 34: 1596–600.
    • (2010) Leuk Res , vol.34 , pp. 1596-1600
    • Wang, J.1    Zhan, P.2    Chen, B.3
  • 34
    • 72249086376 scopus 로고    scopus 로고
    • Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
    • Koppen IJ, Hermans FJ, Kaspers GJ: Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol, 2010; 148: 3–14.
    • (2010) Br J Haematol , vol.148 , pp. 3-14
    • Koppen, I.J.1    Hermans, F.J.2    Kaspers, G.J.3
  • 35
    • 33750090420 scopus 로고    scopus 로고
    • A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
    • Zintzaras E, Koufakis T, Ziakas PD et al: A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol, 2006; 21: 501–10.
    • (2006) Eur J Epidemiol , vol.21 , pp. 501-510
    • Zintzaras, E.1    Koufakis, T.2    Ziakas, P.D.3
  • 36
    • 33750497230 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A metaanalysis
    • Pereira TV, Rudnicki M, Pereira AC et al: 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a metaanalysis. Cancer Epidemiol Biomarkers Prev, 2006; 15: 1956–63.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1956-1963
    • Pereira, T.V.1    Rudnicki, M.2    Pereira, A.C.3
  • 37
    • 84883499962 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia
    • Zheng MM, Yue LJ, Zhang HH et al: Association of single nucleotide polymorphism of methylenetetrahydrofolate reductase gene with susceptibility to acute leukemia. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2013; 30: 451–55.
    • (2013) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.30 , pp. 451-455
    • Zheng, M.M.1    Yue, L.J.2    Zhang, H.H.3
  • 38
    • 84863498117 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population
    • Hussain SR, Naqvi H, Raza ST et al: Methylenetetrahydrofolate reductase C677T genetic polymorphisms and risk of leukaemia among the North Indian population. Cancer Epidemiol, 2012; 36: e227–e231.
    • (2012) Cancer Epidemiol , vol.36
    • Hussain, S.R.1    Naqvi, H.2    Raza, S.T.3
  • 39
    • 84880728298 scopus 로고    scopus 로고
    • Relationship between genetic polymorphism of methylenetetrahydrfolate reductase and the risk of childhood acute lymphocytic leukemia
    • Feng YC, Wu JR: Relationship between genetic polymorphism of methylenetetrahydrfolate reductase and the risk of childhood acute lymphocytic leukemia. Journal of Leukemia & Lymphoma, 2012; 21: 736–38.
    • (2012) Journal of Leukemia & Lymphoma , vol.21 , pp. 736-738
    • Feng, Y.C.1    Wu, J.R.2
  • 40
    • 39149139125 scopus 로고    scopus 로고
    • Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches
    • Zintzaras E, Lau J: Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol, 2008; 61: 634–45.
    • (2008) J Clin Epidemiol , vol.61 , pp. 634-645
    • Zintzaras, E.1    Lau, J.2
  • 41
    • 84872011968 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J et al: The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol, 2009; 62: e1–e34.
    • (2009) J Clin Epidemiol , vol.62
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3
  • 43
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997; 315: 629–34.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 44
    • 84864877162 scopus 로고    scopus 로고
    • Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: The ESCALE study (SFCE)
    • Amigou A, Rudant J, Orsi L et al: Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE). Cancer Causes Control, 2012; 23: 1265–77.
    • (2012) Cancer Causes Control , vol.23 , pp. 1265-1277
    • Amigou, A.1    Rudant, J.2    Orsi, L.3
  • 45
    • 80052052583 scopus 로고    scopus 로고
    • Polymorphisms in folate-related genes: Impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese
    • Yang L, Liu L, Wang J et al: Polymorphisms in folate-related genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese. Leuk Lymphoma, 2011; 52: 1770–76.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1770-1776
    • Yang, L.1    Liu, L.2    Wang, J.3
  • 46
    • 79751524496 scopus 로고    scopus 로고
    • Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: A prospective study
    • te Winkel ML, de Muinck Keizer-Schrama SM, de Jonge R et al: Germline variation in the MTHFR and MTRR genes determines the nadir of bone density in pediatric acute lymphoblastic leukemia: a prospective study. Bone, 2011; 48: 571–77.
    • (2011) Bone , vol.48 , pp. 571-577
    • Te Winkel, M.L.1    De Muinck Keizer-Schrama, S.M.2    De Jonge, R.3
  • 47
    • 80052943694 scopus 로고    scopus 로고
    • Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children
    • Chan JY, Ugrasena DG, Lum DW et al: Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol, 2011; 29: 116–23.
    • (2011) Hematol Oncol , vol.29 , pp. 116-123
    • Chan, J.Y.1    Ugrasena, D.G.2    Lum, D.W.3
  • 48
    • 77649179382 scopus 로고    scopus 로고
    • Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group
    • Yeoh AE, Lu Y, Chan JY et al: Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res, 2010; 34: 276–83.
    • (2010) Leuk Res , vol.34 , pp. 276-283
    • Yeoh, A.E.1    Lu, Y.2    Chan, J.Y.3
  • 49
    • 77951771318 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms: Association with risk for pediatric acute lymphoblastic leukemia in north Indians
    • Sood S, Das R, Trehan A et al: Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians. Leuk Lymphoma, 2010; 51: 928–32.
    • (2010) Leuk Lymphoma , vol.51 , pp. 928-932
    • Sood, S.1    Das, R.2    Trehan, A.3
  • 50
    • 77952667223 scopus 로고    scopus 로고
    • Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population
    • Lv L, Wu C, Sun H et al: Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population. Eur J Haematol, 2010; 84: 506–12.
    • (2010) Eur J Haematol , vol.84 , pp. 506-512
    • Lv, L.1    Wu, C.2    Sun, H.3
  • 52
    • 55049124636 scopus 로고    scopus 로고
    • Association between polymorphisms of folatemetabolizing enzymes and hematological malignancies
    • Kim HN, Kim YK, Lee IK et al: Association between polymorphisms of folatemetabolizing enzymes and hematological malignancies. Leuk Res, 2009; 33: 82–87.
    • (2009) Leuk Res , vol.33 , pp. 82-87
    • Kim, H.N.1    Kim, Y.K.2    Lee, I.K.3
  • 53
    • 64049110710 scopus 로고    scopus 로고
    • Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia
    • de Jonge R, Tissing WJ, Hooijberg JH et al: Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood, 2009; 113: 2284–89.
    • (2009) Blood , vol.113 , pp. 2284-2289
    • De Jonge, R.1    Tissing, W.J.2    Hooijberg, J.H.3
  • 54
    • 36049046978 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia
    • Giovannetti E, Ugrasena DG, Supriyadi E et al: Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res, 2008; 32: 19–24.
    • (2008) Leuk Res , vol.32 , pp. 19-24
    • Giovannetti, E.1    Ugrasena, D.G.2    Supriyadi, E.3
  • 55
    • 45549104666 scopus 로고    scopus 로고
    • 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children
    • Alcasabas P, Ravindranath Y, Goyette G et al: 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. Pediatr Blood Cancer, 2008; 51: 178–82.
    • (2008) Pediatr Blood Cancer , vol.51 , pp. 178-182
    • Alcasabas, P.1    Ravindranath, Y.2    Goyette, G.3
  • 56
    • 34247250804 scopus 로고    scopus 로고
    • Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children
    • Petra BG, Janez J, Vita D: Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children. Leuk Lymphoma, 2007; 48: 786–92.
    • (2007) Leuk Lymphoma , vol.48 , pp. 786-792
    • Petra, B.G.1    Janez, J.2    Vita, D.3
  • 57
    • 35348937632 scopus 로고    scopus 로고
    • Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia
    • Oh D, Kim NK, Jang MJ et al: Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia. Anticancer Res, 2007; 27: 3419–24.
    • (2007) Anticancer Res , vol.27 , pp. 3419-3424
    • Oh, D.1    Kim, N.K.2    Jang, M.J.3
  • 58
    • 61549142463 scopus 로고    scopus 로고
    • Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia
    • Kamel AM, Moussa HS, Ebid GT et al: Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Canc Inst, 2007; 19: 96–105.
    • (2007) J Egypt Natl Canc Inst , vol.19 , pp. 96-105
    • Kamel, A.M.1    Moussa, H.S.2    Ebid, G.T.3
  • 59
    • 34247600674 scopus 로고    scopus 로고
    • The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia
    • Bolufer P, Collado M, Barragan E et al: The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia. Haematologica, 2007; 92: 308–14.
    • (2007) Haematologica , vol.92 , pp. 308-314
    • Bolufer, P.1    Collado, M.2    Barragan, E.3
  • 60
    • 32844474797 scopus 로고    scopus 로고
    • The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population
    • Zanrosso CW, Hatagima A, Emerenciano M et al: The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res, 2006; 30: 477–81.
    • (2006) Leuk Res , vol.30 , pp. 477-481
    • Zanrosso, C.W.1    Hatagima, A.2    Emerenciano, M.3
  • 61
    • 33750094299 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy
    • Timuragaoglu A, Dizlek S, Uysalgil N et al: Methylenetetrahydrofolate reductase C677T polymorphism in adult patients with lymphoproliferative disorders and its effect on chemotherapy. Ann Hematol, 2006; 85: 863–68.
    • (2006) Ann Hematol , vol.85 , pp. 863-868
    • Timuragaoglu, A.1    Dizlek, S.2    Uysalgil, N.3
  • 62
    • 33747697063 scopus 로고    scopus 로고
    • Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population
    • Reddy H, Jamil K: Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma, 2006; 47: 1333–39.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1333-1339
    • Reddy, H.1    Jamil, K.2
  • 63
    • 33746718726 scopus 로고    scopus 로고
    • Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia
    • Kim NK, Chong SY, Jang MJ et al: Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. Anticancer Res, 2006; 26: 2879–81.
    • (2006) Anticancer Res , vol.26 , pp. 2879-2881
    • Kim, N.K.1    Chong, S.Y.2    Jang, M.J.3
  • 64
    • 33646748058 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population
    • Hur M, Park JY, Cho HC et al: Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population. Clin Lab Haematol, 2006; 28: 154–59.
    • (2006) Clin Lab Haematol , vol.28 , pp. 154-159
    • Hur, M.1    Park, J.Y.2    Cho, H.C.3
  • 65
    • 27144534500 scopus 로고    scopus 로고
    • MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia
    • author reply 2591–92
    • Thirumaran RK, Gast A, Flohr T et al: MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood, 2005; 106: 2590–91; author reply 2591–92.
    • (2005) Blood , vol.106 , pp. 2590-2591
    • Thirumaran, R.K.1    Gast, A.2    Flohr, T.3
  • 66
    • 26444545116 scopus 로고    scopus 로고
    • Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population
    • Schnakenberg E, Mehles A, Cario G et al: Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet, 2005; 6: 23.
    • (2005) BMC Med Genet , vol.6
    • Schnakenberg, E.1    Mehles, A.2    Cario, G.3
  • 67
    • 24144492112 scopus 로고    scopus 로고
    • The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal
    • Oliveira E, Alves S, Quental S et al: The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol, 2005; 27: 425–29.
    • (2005) J Pediatr Hematol Oncol , vol.27 , pp. 425-429
    • Oliveira, E.1    Alves, S.2    Quental, S.3
  • 68
    • 0346966836 scopus 로고    scopus 로고
    • Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
    • Krajinovic M, Lamothe S, Labuda D et al: Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood, 2004; 103: 252–57.
    • (2004) Blood , vol.103 , pp. 252-257
    • Krajinovic, M.1    Lamothe, S.2    Labuda, D.3
  • 69
    • 2942608990 scopus 로고    scopus 로고
    • Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin’s lymphoma in adults
    • Gemmati D, Ongaro A, Scapoli GL et al: Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin’s lymphoma in adults. Cancer Epidemiol Biomarkers Prev, 2004; 13: 787–94.
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 787-794
    • Gemmati, D.1    Ongaro, A.2    Scapoli, G.L.3
  • 70
    • 2942543487 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population
    • Chiusolo P, Reddiconto G, Cimino G et al: Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica, 2004; 89: 139–44.
    • (2004) Haematologica , vol.89 , pp. 139-144
    • Chiusolo, P.1    Reddiconto, G.2    Cimino, G.3
  • 71
    • 2042443062 scopus 로고    scopus 로고
    • Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis
    • Deligezer U, Akisik E, Dalay N: Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn, 2003; 7: 181–85.
    • (2003) Mol Diagn , vol.7 , pp. 181-185
    • Deligezer, U.1    Akisik, E.2    Dalay, N.3
  • 72
    • 0037969835 scopus 로고    scopus 로고
    • Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia
    • Balta G, Yuksek N, Ozyurek E et al: Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol, 2003; 73: 154–60.
    • (2003) Am J Hematol , vol.73 , pp. 154-160
    • Balta, G.1    Yuksek, N.2    Ozyurek, E.3
  • 74
    • 38449110586 scopus 로고    scopus 로고
    • A new method for 5,10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy
    • Chen BA, Jiang N, Ji MJ et al: A new method for 5,10-methylenetetrahydrofolate reductase single nucleotide polymorphisms genotyping used to study susceptibility of hematological malignancy. J Exp Hematol, 2006; 14: 1069–73.
    • (2006) J Exp Hematol , vol.14 , pp. 1069-1073
    • Chen, B.A.1    Jiang, N.2    Ji, M.J.3
  • 75
    • 78149361175 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism in childhood acute lymphocytic leukaemia
    • Jiang H, Gu LJ, Xue HL et al: Methylenetetrahydrofolate reductase gene polymorphism in childhood acute lymphocytic leukaemia. Chinese Journal of Hematology, 2004; 25: 439–40.
    • (2004) Chinese Journal of Hematology , vol.25 , pp. 439-440
    • Jiang, H.1    Gu, L.J.2    Xue, H.L.3
  • 76
    • 84924662856 scopus 로고    scopus 로고
    • The association between MTHFR and RFC1 genetic polymorphisms and the risk of acute lymphoblastic leukemia in children
    • Yang Z, He ZK: The association between MTHFR and RFC1 genetic polymorphisms and the risk of acute lymphoblastic leukemia in children. Hunan Provincial Committee of the Pharmacetical Professional Conference, 2009; 80–83.
    • (2009) Hunan Provincial Committee of the Pharmacetical Professional Conference , pp. 80-83
    • Yang, Z.1    He, Z.K.2
  • 78
    • 84870825959 scopus 로고    scopus 로고
    • Relationship between genetic polymorphism of methylenetetrahydrofolate reductase and the risk of childhood acute lymphocytic leukemia
    • Lv H, Wang W, Du ZZ et al: Relationship between genetic polymorphism of methylenetetrahydrofolate reductase and the risk of childhood acute lymphocytic leukemia. J Clin Pediatr, 2011; 29: 414–17.
    • (2011) J Clin Pediatr , vol.29 , pp. 414-417
    • Lv, H.1    Wang, W.2    Du, Z.Z.3
  • 79
    • 84869479955 scopus 로고    scopus 로고
    • Relationship between genetic polymorphism of methylenetetrahydrofolate reductase and the risk of acute lymphocytic leukemia
    • Liu JX, Chen JP, Lin DX: Relationship between genetic polymorphism of methylenetetrahydrofolate reductase and the risk of acute lymphocytic leukemia. Med J Chin PLA, 2008; 33: 1291–93.
    • (2008) Med J Chin PLA , vol.33 , pp. 1291-1293
    • Liu, J.X.1    Chen, J.P.2    Lin, D.X.3
  • 80
    • 78149361485 scopus 로고    scopus 로고
    • The relationship between the methylenetetrahydrofolate reductase C677T gene polymorphism and acute lymphocytic leukemia in children
    • Yu H, Jin RM, Bai Y et al: The relationship between the methylenetetrahydrofolate reductase C677T gene polymorphism and acute lymphocytic leukemia in children. Journal of Clinical Hematology, 2006; 19: 205–6.
    • (2006) Journal of Clinical Hematology , vol.19 , pp. 205-206
    • Yu, H.1    Jin, R.M.2    Bai, Y.3
  • 81
    • 84892470929 scopus 로고    scopus 로고
    • The MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: An updated meta-analysis based on 37 case-control studies
    • Jiang Y, Hou J, Zhang Q et al: The MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: an updated meta-analysis based on 37 case-control studies. Asian Pac J Cancer Prev, 2013; 14: 6357–62.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 6357-6362
    • Jiang, Y.1    Hou, J.2    Zhang, Q.3
  • 82
    • 33749988447 scopus 로고    scopus 로고
    • Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression
    • Bolufer P, Barragan E, Collado M et al: Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. Leuk Res, 2006; 30: 1471–91.
    • (2006) Leuk Res , vol.30 , pp. 1471-1491
    • Bolufer, P.1    Barragan, E.2    Collado, M.3
  • 83
    • 84901341871 scopus 로고    scopus 로고
    • Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: A meta-analysis
    • Xia J, Wang Y, Zhang H, Hu Y: Association between MTR A2756G polymorphism and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Lymphoma, 2013; 55: 1388–93.
    • (2013) Leuk Lymphoma , vol.55 , pp. 1388-1393
    • Xia, J.1    Wang, Y.2    Zhang, H.3    Hu, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.