Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Acute Lymphoblastic Leukemia-Evidence from an updated meta-analysis including 35 studies

BMC Medical Genetics

Volumn 13, Issue , 2012, Pages

  Wang, Haigang ^a,b   Wang, Jiali ^a   Zhao, Lixia ^a,b   Liu, Xinchun ^a   Mi, Wenjie ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

5,10 methylenetetrahydrofolate reductase; Acute lymphoblastic leukemia; Meta analysis; Polymorphism; Update

Indexed keywords

ALANINE; CYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); THREONINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; CANCER RISK; CAUCASIAN; CHILDHOOD CANCER; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; EMBASE; EVIDENCE BASED MEDICINE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MEDLINE; META ANALYSIS; RISK ASSESSMENT; SEX DIFFERENCE; SYSTEMATIC REVIEW;

CASE-CONTROL STUDIES; COHORT STUDIES; CROSS-SECTIONAL STUDIES; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK FACTORS;

EID: 84865620566     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-13-77     Document Type: Article

References (64)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun MJ. Cancer statistics, 2006. CA Cancer J Clin 2006, 56(2):106-130. 10.3322/canjclin.56.2.106, 16514137.
2. Karathanasis NV, Choumerianou DM, Kalmanti M. Gene polymorphisms in childhood ALL. Pediatr Blood Cancer 2009, 52(3):318-323. 10.1002/pbc.21825, 18989891.
3. Faderl S, O'Brien S, Pui CH, Stock W, Wetzler M, Hoelzer D, Kantarjian HM. Adult acute lymphoblastic leukemia: concepts and strategies. Cancer 2010, 116(5):1165-1176. 10.1002/cncr.24862, 20101737.
4. Onciu M. Acute lymphoblastic leukemia. Hematol Oncol Clin North Am 2009, 23(4):655-674. 10.1016/j.hoc.2009.04.009, 19577163.
5. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A 2001, 98(7):4004-4009. 10.1073/pnas.061408298, 31169, 11274424.
6. Goyette P, Sumner JS, Milos R, Duncan AM, Rosenblatt DS, Matthews RG, Rozen R. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994, 7(2):195-200. 10.1038/ng0694-195, 7920641.
7. Gaughan DJ, Barbaux S, Kluijtmans LA, Whitehead AS. The human and mouse methylenetetrahydrofolate reductase (MTHFR) genes: genomic organization, mRNA structure and linkage to the CLCN6 gene. Gene 2000, 257(2):279-289. 10.1016/S0378-1119(00)00392-9, 11080594.
8. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2001, 22(4):195-201. 10.1016/S0165-6147(00)01675-8, 11282420.
9. Kluijtmans LA, Kastelein JJ, Lindemans J, Boers GH, Heil SG, Bruschke AV, Jukema JW, van den Heuvel LP, Trijbels FJ, Boerma GJ, Verheugt FW, Willems F, Blom HJ. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1997, 96(8):2573-2577. 10.1161/01.CIR.96.8.2573, 9355896.
10. van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects. Am J Hum Genet 1998, 62(5):1044-1051. 10.1086/301825, 1377082, 9545395.
11. Ou CY, Stevenson RE, Brown VK, Schwartz CE, Allen WP, Khoury MJ, Rozen R, Oakley GP, Adams MJ. 5,10 Methylenetetrahydrofolate reductase genetic polymorphism as a risk factor for neural tube defects. Am J Med Genet 1996, 63(4):610-614. 10.1002/(SICI)1096-8628(19960628)63:4<610::AID-AJMG15>3.0.CO;2-L, 8826441.
12. Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2006, 15(10):1956-1963. 10.1158/1055-9965.EPI-06-0334, 17035405.
13. Zintzaras E, Koufakis T, Ziakas PD, Rodopoulou P, Giannouli S, Voulgarelis M. A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 2006, 21(7):501-510. 10.1007/s10654-006-9027-8, 16897583.
14. Koppen IJ, Hermans FJ, Kaspers GJ. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2010, 148(1):3-14. 10.1111/j.1365-2141.2009.07898.x, 19775302.
15. Wang J, Zhan P, Chen B, Zhou R, Yang Y, Ouyang J. MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: a meta-analysis. Leuk Res 2010, 34(12):1596-1600. 10.1016/j.leukres.2010.03.034, 20409583.
16. Zacho J, Yazdanyar S, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. Hyperhomocysteinemia, methylenetetrahydrofolate reductase c.677C>T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75,000 cases and 93,000 controls. Int J Cancer 2011, 128(3):644-652. 10.1002/ijc.25375, 20473868.
17. Yan J, Yin M, Dreyer ZE, Scheurer ME, Kamdar K, Wei Q, Okcu MF. A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012, 58(4):513-518. 10.1002/pbc.23137, 21495160.
18. Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol 2008, 61(7):634-645. 10.1016/j.jclinepi.2007.12.011, 18538260.
19. Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 2005, 28(2):123-137. 10.1002/gepi.20048, 15593093.
20. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003, 327(7414):557-560. 10.1136/bmj.327.7414.557, 192859, 12958120.
21. Pereira TV, Rudnicki M, Cheung BM, Baum L, Yamada Y, Oliveira PS, Pereira AC, Krieger JE. Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias. J Hypertens 2007, 25(9):1763-1774. 10.1097/HJH.0b013e3281de740d, 17762636.
22. Macaskill P, Walter SD, Irwig L. A comparison of methods to detect publication bias in meta-analysis. Stat Med 2001, 20(4):641-654. 10.1002/sim.698, 11223905.
23. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A 1999, 96(22):12810-12815. 10.1073/pnas.96.22.12810, 23109, 10536004.
24. Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RP. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001, 115(3):616-618. 10.1046/j.1365-2141.2001.03140.x, 11736945.
25. Deligezer U, Akisik E, Dalay N. Genotyping of the MTHFR gene polymorphism, C677T in patients with leukemia by melting curve analysis. Mol Diagn 2003, 7(3-4):181-185.
26. Balta G, Yuksek N, Ozyurek E, Ertem U, Hicsonmez G, Altay C, Gurgey A. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003, 73(3):154-160. 10.1002/ajh.10339, 12827651.
27. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, Sinnett D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004, 103(1):252-257. 10.1182/blood-2003-06-1794, 12958073.
28. Gemmati D, Ongaro A, Scapoli GL, Della PM, Tognazzo S, Serino ML, Di BE, Rodeghiero F, Gilli G, Reverberi R, Caruso A, Pasello M, Pellati A, De Mattei M. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004, 13(5):787-794.
29. Chiusolo P, Reddiconto G, Cimino G, Sica S, Fiorini A, Farina G, Vitale A, Sora F, Laurenti L, Bartolozzi F, Fazi P, Mandelli F, Leone G. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica 2004, 89(2):139-144.
30. Schnakenberg E, Mehles A, Cario G, Rehe K, Seidemann K, Schlegelberger B, Elsner HA, Welte KH, Schrappe M, Stanulla M. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005, 6:23. 1164414, 15921520.
31. Oliveira E, Alves S, Quental S, Ferreira F, Norton L, Costa V, Amorim A, Prata MJ. The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol 2005, 27(8):425-429. 10.1097/01.mph.0000177513.81465.94, 16096524.
32. Thirumaran RK, Gast A, Flohr T, Burwinkel B, Bartram C, Hemminki K, Kumar R. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005, 106(7):2590-2591. author reply 2591-2592, 10.1182/blood-2005-04-1719, 16172254.
33. Zanrosso CW, Hatagima A, Emerenciano M, Ramos F, Figueiredo A, Felix TM, Segal SL, Giugliani R, Muniz MT, Pombo-de-Oliveira MS. The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population. Leuk Res 2006, 30(4):477-481. 10.1016/j.leukres.2005.08.008, 16182363.
34. Reddy H, Jamil K. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma 2006, 47(7):1333-1339. 10.1080/10428190600562773, 16923565.
35. Kim NK, Chong SY, Jang MJ, Hong SH, Kim HS, Cho EK, Lee JA, Ahn MJ, Kim CS, Oh D. Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. Anticancer Res 2006, 26(4B):2879-2881.
36. Hur M, Park JY, Cho HC, Lee KM, Shin HY, Cho HI. Methylenetetrahydrofolate reductase A1298C genotypes are associated with the risks of acute lymphoblastic leukaemia and chronic myelogenous leukaemia in the Korean population. Clin Lab Haematol 2006, 28(3):154-159. 10.1111/j.1365-2257.2006.00769.x, 16706930.
37. Chatzidakis K, Goulas A, Athanassiadou-Piperopoulou F, Fidani L, Koliouskas D, Mirtsou V. Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients. Pediatr Blood Cancer 2006, 47(2):147-151. 10.1002/pbc.20574, 16123993.
38. Petra BG, Janez J, Vita D. Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children. Leuk Lymphoma 2007, 48(4):786-792. 10.1080/10428190601187711, 17454638.
39. Oh D, Kim NK, Jang MJ, Kim HC, Lee JH, Lee JA, Ahn MJ, Kim CS, Kim HS, Park S, Chio HS, Min YH. Association of the 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) polymorphisms in Korean patients with adult acute lymphoblastic leukemia. Anticancer Res 2007, 27(5A):3419-3424.
40. Kamel AM, Moussa HS, Ebid GT, Bu RR, Bhatia KG. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Canc Inst 2007, 19(2):96-105.
41. Bolufer P, Collado M, Barragan E, Cervera J, Calasanz MJ, Colomer D, Roman-Gomez J, Sanz MA. The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia. Haematologica 2007, 92(3):308-314. 10.3324/haematol.10752, 17339179.
42. Giovannetti E, Ugrasena DG, Supriyadi E, Vroling L, Azzarello A, de Lange D, Peters GJ, Veerman AJ, Cloos J. Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res 2008, 32(1):19-24. 10.1016/j.leukres.2007.02.011, 17395259.
43. Alcasabas P, Ravindranath Y, Goyette G, Haller A, Del RL, Lesaca-Medina MY, Darga L, Ostrea EM, Taub JW, Everson RB. 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and the risk of acute lymphoblastic leukemia (ALL) in Filipino children. Pediatr Blood Cancer 2008, 51(2):178-182. 10.1002/pbc.21511, 18421714.
44. Kim HN, Kim YK, Lee IK, Yang DH, Lee JJ, Shin MH, Park KS, Choi JS, Park MR, Jo DY, Won JH, Kwak JY, Kim HJ. Association between polymorphisms of folate-metabolizing enzymes and hematological malignancies. Leuk Res 2009, 33(1):82-87. 10.1016/j.leukres.2008.07.026, 18774170.
45. de Jonge R, Tissing WJ, Hooijberg JH, Jansen G, Kaspers GJ, Lindemans J, Peters GJ, Pieters R. Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia. Blood 2009, 113(10):2284-2289. 10.1182/blood-2008-07-165928, 19020309.
46. Lv L, Wu C, Sun H, Zhu S, Yang Y, Chen X, Fu H, Bao L. Combined 677CC/1298 AC genotypes of methylenetetrahydrofolate reductase (MTHFR ) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population. Eur J Haematol 2010, 84(6):506-512. 10.1111/j.1600-0609.2010.01430.x, 20374270.
47. Damnjanovic T, Milicevic R, Novkovic T, Jovicic O, Bunjevacki V, Jekic B, Lukovic L, Novakovic I, Redzic D, Milasin J. Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children. J Pediatr Hematol Oncol 2010, 32(4):e148-150. 10.1097/MPH.0b013e3181cbd252, 20445408.
48. Yeoh AE, Lu Y, Chan JY, Chan YH, Ariffin H, Kham SK, Quah TC. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res 2010, 34(3):276-283. 10.1016/j.leukres.2009.07.003, 19651439.
49. Tong N, Fang Y, Li J, Wang M, Lu Q, Wang S, Tian Y, Rong L, Sun J, Xu J, Zhang Z. Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population. Cancer Sci 2010, 101(3):782-786. 10.1111/j.1349-7006.2009.01429.x, 20002681.
50. Sood S, Das R, Trehan A, Ahluwalia J, Sachdeva MU, Varma N, Bansal D, Marwaha RK. Methylenetetrahydrofolate reductase gene polymorphisms: association with risk for pediatric acute lymphoblastic leukemia in north Indians. Leuk Lymphoma 2010, 51(5):928-932. 10.3109/10428191003719023, 20367562.
51. Sadananda AMN, Chandy S, Ramachandra N, Appaji L, Aruna KBS, Ramaswamy G, Savithri HS, Krishnamoorthy L. Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children. Indian J Cancer 2010, 47(1):40-45. 10.4103/0019-509X.58858, 20071789.
52. Lightfoot TJ, Johnston WT, Painter D, Simpson J, Roman E, Skibola CF, Smith MT, Allan JM, Taylor GM. Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood 2010, 115(19):3923-3929. 10.1182/blood-2009-10-249722, 2869556, 20101025.
53. Chan JY, Ugrasena DG, Lum DW, Lu Y, Yeoh AE. Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol 2011, 29(3):116-123. 10.1002/hon.965, 20824655.
54. Karathanasis NV, Stiakaki E, Goulielmos GN, Kalmanti M. The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia. Genet Test Mol Biomarkers 2011, 15(1-2):5-10.
55. Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia. Eur J Epidemiol 2006, 21(12):885-886.
56. Zhao P, Lin F, Li Z, Lin B, Lin J, Luo R. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer. Asian Pac J Cancer Prev 2011, 12(8):2019-2023.
57. Boccia S, Hung R, Ricciardi G, Gianfagna F, Ebert MP, Fang JY, Gao CM, Gotze T, Graziano F, Lacasana-Navarro M, Lin D, Lopez-Carrillo L, Qiao YL, Shen H, Stolzenberg-Solomon R, Takezaki T, Weng YR, Zhang FF, van Duijin CM, Boffetta P, Taioli E. Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review. Am J Epidemiol 2008, 167(5):505-516.
58. Taioli E, Garza MA, Ahn YO, Bishop DT, Bost J, Budai B, Chen K, Gemignani F, Keku T, Lima CS, Le ML, Matsuo K, Moreno V, Plaschke J, Pufulete M, Thomas SB, Toffoli G, Wolf CR, Moore CG, Little J. Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. Am J Epidemiol 2009, 170(10):1207-1221. 10.1093/aje/kwp275, 2781761, 19846566.
59. Bolufer P, Barragan E, Collado M, Cervera J, Lopez JA, Sanz MA. Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. Leuk Res 2006, 30(12):1471-1491. 10.1016/j.leukres.2006.01.016, 17023046.
60. Kim YI. Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis. Nutr Rev 2000, 58(7):205-209.
61. Zhao Y, Hao L, Zhang L, Tian Y, Cao Y, Xia H, Deng Y, Wang T, Yu M, Li Z. Plasma folate status and dietary folate intake among Chinese women of childbearing age. Matern Child Nutr 2009, 5(2):104-116. 10.1111/j.1740-8709.2008.00172.x, 19292745.
62. Bassan R, Gatta G, Tondini C, Willemze R. Adult acute lymphoblastic leukaemia. Crit Rev Oncol Hematol 2004, 50(3):223-261. 10.1016/j.critrevonc.2003.11.003, 15182827.
63. Milne E, Royle JA, Miller M, Bower C, de Klerk NH, Bailey HD, van Bockxmeer F, Attia J, Scott RJ, Norris MD, Haber M, Thompson JR, Fritschi L, Marshall GM, Armstrong BK. Maternal folate and other vitamin supplementation during pregnancy and risk ofacute lymphoblastic leukemia in the offspring. Int J Cancer 2010, 126(11):2690-2699.
64. Thompson JR, Gerald PF, Willoughby ML, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet 2001, 358(9297):1935-1940. 10.1016/S0140-6736(01)06959-8, 11747917.