Methylenetetrahydrofolate reductase polymorphism C677T Is a protective factor for pediatric acute lymphoblastic leukemia in the chinese population: A meta-analysis

Genetic Testing and Molecular Biomarkers

Volumn 16, Issue 12, 2012, Pages 1401-1407

  Wang, Haigang ^a,b   Meng, Lujing ^a   Zhao, Lixia ^a,b   Wang, Jiali ^a   Liu, Xinchun ^a   Mi, Wenjie ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; CHILD; CHINESE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; PRESCHOOL CHILD; RISK FACTOR; SCHOOL CHILD;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CHILD; CONFIDENCE INTERVALS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK FACTORS;

EID: 84869404521     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2012.0184     Document Type: Article

References (31)

1. Friedman G, Goldschmidt N, Friedlander Y, et al. (1999) A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. J Nutr 129:1656-1661.
2. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558.
3. Jiang H, Xue HL, Pan C, et al. (2004) Methylenetetrahydrofolate reductase gene polymorphism in childhood acute lymphocytic leukaemia. Zhonghua Xue Ye Xue Za Zhi 7:57-58.
4. Karathanasis NV, Stiakaki E, Goulielmos GN, et al. (2011) The role of the methylenetetrahydrofolate reductase 677 and 1298 polymorphisms in Cretan children with acute lymphoblastic leukemia. Genet Test Mol Biomarkers 15:5-10.
5. Koppen IJ, Hermans FJ, Kaspers GJ (2010) Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 148:3-14.
6. Liu JX, Chen JP, Lin DX (2008) Relationship between genetic polymorphism of methylenetetrahydrofolate reductase and the risk of acute lymphocytic leukemia. Med J Chin PLA11: 1291-1293.
7. Lv H, Wang W, Du ZZ, et al. (2011) Relationship between genetic polymorphism of methylenetetrah* drofolate reduetase and the risk of childhood acute lymphocytic leukemia. J Clin Pediatr 5:414-417.
8. Lv L, Wu C, Sun H, et al. (2010) Combined 677CC/1298AC genotypes of methylenetetrahydrofolate reductase (MTHFR) reduce susceptibility to precursor B lymphoblastic leukemia in a Chinese population. Eur J Haematol 84:506-512.
9. Macaskill P,Walter SD, Irwig L (2001)Acomparison ofmethods to detect publication bias in meta-analysis. Stat Med 20:641-654.
10. McNeer JL (2011) The complex interplay between folate metabolism and risk of acute lymphoblastic leukemia. Leuk Lymphoma 52:1621-1622.
11. Pereira TV, Rudnicki M, Pereira AC, et al. (2006) 5,10- Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblasticleukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1956-1963.
12. Robien K, Ulrich CM (2003) 5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview. Am J Epidemiol 157:571-582.
13. Sadananda AMN, Chandy S, Ramachandra N, et al. (2010) Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children. Indian J Cancer 47:40-45.
14. Scelo G, Metayer C, Zhang L, et al. (2009) Household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia. Environ Health Perspect 117:133-139.
15. Skibola CF, Smith MT, Kane E, et al. (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 96:12810-12815.
16. Tong N, Fang Y, Li J, et al. (2010) Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population. Cancer Sci 101:782-786.
17. Tong N, Sheng X, Wang M, et al. (2011) Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblasticleukemia risk: a meta-analysis based on 28 case-control studies. Leuk Lymphoma 52:1949-1960.
18. Trikalinos TA, Salanti G, Khoury MJ, et al. (2006) Impact of violations and deviations in Hardy-Weinberg equilibrium on postulatedgene-disease associations. Am J Epidemiol 163: 300-309.
19. Wang HG, Wang JL, Chang P, et al. (2010a) Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese. Genet Mol Res 9:1896-1907.
20. Wang J, Zhan P, Chen B, et al. (2010b) MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: ameta-analysis. Leuk Res 34:1596-1600.
21. Weisberg IS, Jacques PF, Selhub J, et al. (2001) The 1298A-C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156:409-415.
22. Yan J, Yin M, Dreyer ZE, et al. (2012) A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 58: 513-518.
23. Yang L, Liu L, Wang J, et al. (2011) Polymorphisms in folaterelated genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese. Leuk Lymphoma. 52:1770-1706.
24. Yeoh AE, Lu Y, Chan JY, et al. (2010) Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: results from the Malaysia-Singapore ALL Study Group. Leuk Res 34:276-283.
25. Yu H (2004) The Relationship Between the MTHFR Gene Polymorphisms and Childhood Acute Lymphocytic Leukemia as Well as the Toxicity of MTX [D]. Huazhong University of Science and Technology, Wuhan.
26. Yu J (2010) Association of Drug Metabolizing Enzymes Genetic Polymorphisms with the Susceptibility and Methotrexateinduced Toxicities in Childhood Acute Leukemia [D]. Southern Medical University, Guangdong.
27. Zhang J (2007) A Study on the Serum Folate Level and Methylenetetrahydrofolate Reductase Genetic Polymorphisms in Adult Acute Lymphocytic Leukemia[D]. Hebei Medical University, Shijiazhuang.
28. Zintzaras E, Doxani C, Rodopoulou P, et al. (2012) Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: a synthesis of genetic association studies. Cancer Epidemiol 36:169-176.
29. Zintzaras E, Ioannidis JP (2005) Heterogeneity testing in metaanalysis of genome searches. Genet Epidemiol 28:123-137.
30. Zintzaras E, Kitsios G, Stefanidis I (2006) Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis. Hypertension 48:700-710.
31. Zintzaras E, Lau J (2008) Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol. 61:634-645.