Methylenetetrahydrofolate reductase polymorphisms, serum methylenetetrahydrofolate reductase levels, and risk of childhood acute lymphoblastic leukemia in a Chinese population

Cancer Science

Volumn 101, Issue 3, 2010, Pages 782-786

  Tong, Na ^a   Fang, Yongjun ^b   Li, Jie ^c   Wang, Meilin ^a   Lu, Qin ^b   Wang, Shizhi ^a   Tian, Yuanyuan ^a   Rong, Liucheng ^b   Sun, Jielin ^d   Xu, Jianfeng ^d   Zhang, Zhengdong ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CHILD; CHINESE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; GENOTYPE; HUMANS; INFANT; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK;

EID: 77949615888     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01429.x     Document Type: Article

References (40)

1. Pui CH. Acute lymphoblastic leukemia in children. Curr Opin Oncol 2000, 12:3-12.
2. Jemal A, Siegel R, Ward E. Cancer statistics, 2008. CA Cancer J Clin 2008, 58:71-96.
3. Rampersaud GC, Kauwell GP, Bailey LB. Folate: a key to optimizing health and reducing disease risk in the elderly. J Am Coll Nutr 2003, 22:1-8.
4. Krajinovic M, Lamothe S, Labuda D. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood 2004, 103:252-7.
5. Friso S, Choi SW, Girelli D. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002, 99:5606-11.
6. Jacques PF, Bostom AG, Williams RR. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996, 93:7-9.
7. Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb Haemost 1997, 78:523-6.
8. van der Put NM, Gabreels F, Stevens EM. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 1998, 62:1044-51.
9. Weisberg IS, Jacques PF, Selhub J. The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 2001, 156:409-15.
10. Chen J, Giovannucci E, Kelsey K. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996, 56:4862-4.
11. Ma J, Stampfer MJ, Giovannucci E. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Res 1997, 57:1098-102.
12. Manuguerra M, Matullo G, Veglia F. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions. Carcinogenesis 2007, 28:414-22.
13. Aplenc R, Thompson J, Han P. Methylenetetrahydrofolate reductase polymorphisms and therapy response in pediatric acute lymphoblastic leukemia. Cancer Res 2005, 65:2482-7.
14. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001, 98:4004-9.
15. Lee KM, Ward MH, Han S. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res 2009, 33:250-8.
16. Pang D, McNally R, Birch JM. Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study. Br J Cancer 2003, 88:373-81.
17. Ji BT, Shu XO, Linet MS. Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers. J Natl Cancer Inst 1997, 89:238-44.
18. Severson RK, Buckley JD, Woods WG, Benjamin D, Robison LL. Cigarette smoking and alcohol consumption by parents of children with acute myeloid leukemia: an analysis within morphological subgroups - a report from the Childrens Cancer Group. Cancer Epidemiol Biomarkers Prev 1993, 2:433-9.
19. Shu XO, Ross JA, Pendergrass TW, Reaman GH, Lampkin B, Robison LL. Parental alcohol consumption, cigarette smoking, and risk of infant leukemia: a Childrens Cancer Group study. J Natl Cancer Inst 1996, 88:24-31.
20. Petridou E, Trichopoulos D, Kalapothaki V. The risk profile of childhood leukaemia in Greece: a nationwide case-control study. Br J Cancer 1997, 76:1241-7.
21. Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D. Childhood acute lymphoblastic leukemia associated with parental alcohol consumption and polymorphisms of carcinogen-metabolizing genes. Epidemiology 2002, 13:277-81.
22. Freedman DM, Stewart P, Kleinerman RA. Household solvent exposures and childhood acute lymphoblastic leukemia. Am J Public Health 2001, 91:564-7.
23. Kang S, Kim JW, Kang GH. Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. Gynecol Oncol 2005, 96:173-80.
24. Wang M, Zhu H, Fu G. Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis. Clin Exp Med 2009, 9:9-19.
25. Chatzidakis K, Goulas A, Athanassiadou-Piperopoulou F, Fidani L, Koliouskas D, Mirtsou V. Methylenetetrahydrofolate reductase C677T polymorphism: association with risk for childhood acute lymphoblastic leukemia and response during the initial phase of chemotherapy in greek patients. Pediatr Blood Cancer 2006, 47:147-51.
26. Gemmati D, Ongaro A, Scapoli GL. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev 2004, 13:787-94.
27. Chiusolo P, Reddiconto G, Cimino G. Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population. Haematologica 2004, 89:139-44.
28. Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RP. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001, 115:616-8.
29. Balta G, Yuksek N, Ozyurek E. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003, 73:154-60.
30. Oliveira E, Alves S, Quental S. The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol 2005, 27:425-9.
31. Schnakenberg E, Mehles A, Cario G. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005, 6:23.
32. Giovannetti E, Ugrasena DG, Supriyadi E. Methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase promoter (TSER) polymorphisms in Indonesian children with and without leukemia. Leuk Res 2008, 32:19-24.
33. Kamel AM, Moussa HS, Ebid GT, Bu RR, Bhatia KG. Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. J Egypt Natl Canc Inst 2007, 19:96-105.
34. Dunwell TL, Hesson LB, Pavlova T. Epigenetic analysis of childhood acute lymphoblastic leukemia. Epigenetics 2009, 4:185-93.
35. Mesquita DR, Cordoba JC, Magalhaes IQ. Molecular and chromosomal mutations among children with B-lineage lymphoblastic leukemia in Brazil's Federal District. Genet Mol Res 2009, 8:345-53.
36. Kim NK, Chong SY, Jang MJ. Association of the methylenetetrahydrofolate reductase polymorphism in Korean patients with childhood acute lymphoblastic leukemia. Anticancer Res 2006, 26:2879-81.
37. Reddy H, Jamil K. Polymorphisms in the MTHFR gene and their possible association with susceptibility to childhood acute lymphocytic leukemia in an Indian population. Leuk Lymphoma 2006, 47:1333-9.
38. Frosst P, Blom HJ, Milos R. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995, 10:111-3.
39. Dianov GL, Timchenko TV, Sinitsina OI, Kuzminov AV, Medvedev OA, Salganik RI. Repair of uracil residues closely spaced on the opposite strands of plasmid DNA results in double-strand break and deletion formation. Mol Gen Genet 1991, 225:448-52.
40. Thirumaran RK, Gast A, Flohr T. MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia. Blood 2005, 106:2590-1. author reply 1-2