Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population

Haematologica

Volumn 89, Issue 2, 2004, Pages 139-144

  Chiusolo, Patrizia ^a,c   Reddiconto, Giovanni ^a   Cimino, Giuseppe ^b   Sica, Simona ^a   Fiorini, Alessia ^a   Farina, Giuliana ^a   Vitale, Antonella ^b   Sorà, Federica ^a   Laurenti, Luca ^a   Bartolozzi, Francesco ^a   Fazi, Paola ^b   Mandelli, Franco ^b   Leone, Giuseppe ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Acute leukemia susceptibility; DNA repair; MTHFR gene

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2);

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELISM; ARTICLE; CANCER RISK; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA METHYLATION; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME POLYMORPHISM; FOLATE METABOLISM; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MTHFR GENE; PATHOGENESIS; POPULATION RESEARCH; SOUTHERN EUROPE; STATISTICAL ANALYSIS; WILD TYPE; ACUTE LYMPHOCYTIC LEUKEMIA; ALLELE; AMINO ACID SUBSTITUTION; COMPARATIVE STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HYPERHOMOCYSTEINEMIA; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POINT MUTATION; PREVALENCE; RISK;

ALLELES; AMINO ACID SUBSTITUTION; DNA MUTATIONAL ANALYSIS; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERHOMOCYSTEINEMIA; ITALY; LEUKEMIA, LYMPHOCYTIC, ACUTE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION, MISSENSE; POINT MUTATION; PREVALENCE; RISK;

EID: 2942543487     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Bailey LB, Gregory JP. Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr 1999;129:919-22.
2. Bailey LB, Gregory JF. Folate metabolism and requirements. J Nutr 1999;129:779-82.
3. Ueland PM, Hustad S, Schneede J, Refsum H, Vollset SE. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 2001;22:195-201.
4. Kang SS, Passen EL, Ruggie N, Wong PW, Sora H. Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1993;88: 1463-9.
5. Refsum H, Ueland PM, Nyggard O, Vollset SE. Homoeysteine and cardiovascular disease. Annu Rev Med 1998;49:31-62.
6. Finnell RH, Greer KA, Barber RC, Piedrahita JA. Neural tube and craniofacial defects with special emphasis on folate pathway genes. Crit Rev Oral Biol Med 1998;9:38-53.
7. Laivuori H, Kaaja R, Ylikorkala O, Hiltunen T, Kontula K. 677C→T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia. Obstetr Gynecol 2000;96:277-80.
8. Nielsen JN, Larsen TB, Fredholm L, Brandslund I, Munkholm P, Hey H. Increased prevalence of methylenetetrahydrofolate reductase C677T variants in patients with IBD. Gut 2000;47:456-7.
9. Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 1996;56:4862-4.
10. Chen J, Giovannucci E, Hunter DJ. MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among US men and women: an example of gene enviroment interactions in colorectal tumorigenesis. J Nutr 1999; 129:560S-4S.
11. Gershoni-Baruch R, Dagan E, Israeli D, Kasinetz L, Kadouri E, Friedman E. Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women. Eur J Cancer 2000;36:2313-6.
12. Song C, Xing D, Tan W, Wei Q, Lin D. Methylenetetrahydrofolate reductase polymorphisms increase risk of esophageal squamous cell carcinoma in a chinese population. Cancer Res 2000;61: 3272-5.
13. Shen H, Spitz MR, Wang LE, Hong WK, Wei Q. Polymorphism of methylenetetrahydrofolate reductase and the risk of lung cancer: a case-control study. Cancer Epidem Bio Prevent 2001;10:397-401.
14. Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metabol 1998;64:169-72.
15. Weisberg JS, Jacques PF, Selhud J, Bostom AG, Chen Z, Curtis Ellis Eckfeldt JH. The 1298 A→C polymorphism in the methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 2001;156:409-15.
16. Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, et al. Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA 1999;96:12810-5.
17. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
18. Schwahn B, Rozen R. Polymorphisms in the methylenetetrahydrofolate reductase: clinical consequences. Am J Pharmacogenomics 2001;1:189-201.
19. Rosenberg N, Murata M, Ikeda Y, Opare-Sem O, Zivelin A, Geffen E, et al. The frequent 5,10-methylenetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese and Africans. Am J Hum Genet 2002;70:758-62.
20. Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGe review. Ann J Epidemiol 2000;151:862-77.
21. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylentetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. The United Kingdom Childhood Cancer Study Investigators. Proc Natl Acad Sci USA 2001;98:4004-9.
22. Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decrease the risk of childhood acute lymphocytic leukemia. Br J Haematol 2001;115:616-8.
23. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Sinnett D. Role of the MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood Blood 2004; 103:252-7. Epub 2003 Sep 04.
24. Papa A, De Stefano V, Danese S, Chiusolo P, Persichilli S, Casorelli I, et al. Hyperhomocysteinemia and prevalence of polymorphisms of homocisteine metabolism-related enzymes in patients with inflammatory bowel disease. Am J Gastroenterol 2001;96:2677-82.
25. De Stefano V, Chiusolo P, Paciaroni K, Serra FG, Voso MT, Casorelli I, et al. Prevalence of the 677C to T mutation in the methylenetetrahydrofolate reductase gene in Italian patients with venous thrombotic disease. Thromb Haemost 1998;79:686-7.
26. Stuppia L, Gatta V, Gaspari AR, Antonucci I, Morizio E, Calabrese G, et al. C677T mutation in the 5,10-MTHFR gene and risk of Down syndrome in Italy. Eur J Hum Genet 2002;10:388-90.
27. Abbate R, Sardi I, Pepe G, Marcucci R, Brunelli T, Prisco D, et al. The high prevalence of thermolabile 5-10 methyltetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease. Thromb Haemost 1998;79:727-30.
28. D'Elia AV, Driul L, Giacomello R, Colaone R, Fabbro D, Di Leonardo C, et al. Frequency of factor V, prothrombin and methylenetetra hydrofolate reductase gene variants in preeclampsia. Gynecol Obstet Invest 2002;53:84-7.
29. de Franchis R, Sebastio G, Mandato C, Andria G, Mastroiacovo P. Spina bifida, 677C-T mutation, and role of folate. Lancet 1997;346:1703.
30. Pallaud C, Stranieri C, Sass C, Siest G, Pignatti F, Visvikis S. Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population. Clin Chem Lab Med 2001;39:146-54.
31. Chiusolo P, Reddiconto G, Casorelli I, Laurenti L, Sorȧ F, Mele L, et al. Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate. Ann Oncol 2002;13:1915-8.
32. Kishi S, Griener J, Cheng C, Das S, Cook EH, Pei D, et al. Homoeysteine, pharmacogenetics and neurotoxicity in children with leukemia. J Clin Oncol 2003;21: 3084-91.