Gene - Gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children

Leukemia and Lymphoma

Volumn 48, Issue 4, 2007, Pages 786-792

  Bohanec, Grabar Petra ^a   Jazbec, Janez ^b   Dolẑan, Vita ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

ALL; Children; Folate; Methylation; Polymorphism; Risk

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); DNA; FOLIC ACID; METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE; THYMIDYLATE SYNTHASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CHILD; CHILDHOOD LEUKEMIA; CONFIDENCE INTERVAL; CONTROLLED STUDY; DNA METHYLATION; DNA POLYMORPHISM; FEMALE; FOLATE METABOLISM; GENE FREQUENCY; GENE INTERACTION; GENETIC ANALYSIS; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK REDUCTION;

ADOLESCENT; ADULT; CHILD; FEMALE; FOLIC ACID; GENOTYPE; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; MODELS, GENETIC; POLYMORPHISM, GENETIC; PROTEIN INTERACTION MAPPING; RISK;

EID: 34247250804     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190601187711     Document Type: Article

References (35)

1. Kim, Y. I. (2004) Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer?. Cancer Epidemiol Biomarkers Prev, 13, pp. 511-519.
2. Davis, C. D. and Uthus, E. O. (2004) DNA methylation, cancer susceptibility, and nutrient interactions. Exp Biol Med (Maywood), 229, pp. 988-995.
3. Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A. and Matthews, R. G. (1995) A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet, 10, pp. 111-113.
4. van der Put, N. M., Gabreels, F., Stevens, E. M., Smeitink, J. A., Trijbels, F. J. and Eskes, T. K. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?. Am J Hum Genet, 62, pp. 1044-1051.
5. Krajinovic, M., Lamothe, S., Labuda, D., Lemieux-Blanchard, E., Theoret, Y. and Moghrabi, A. (2004) Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood, 103, pp. 252-257.
6. Skibola, C. F., Smith, M. T., Kane, E., Roman, E., Rollinson, S. and Cartwright, R. A. (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci USA, 96, pp. 12810-12815.
7. Kaneda, S., Takeishi, K., Ayusawa, D., Shimizu, K., Seno, T. and Altman, S. (1987) Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA. Nucleic Acids Res, 15, pp. 1259-1270.
8. Horie, N., Aiba, H., Oguro, K., Hojo, H. and Takeishi, K. (1995) Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct, 20, pp. 191-197.
9. Skibola, C. F., Smith, M. T., Hubbard, A., Shane, B., Roberts, A. C. and Law, G. R. (2002) Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood, 99, pp. 3786-3791.
10. Hishida, A., Matsuo, K., Hamajima, N., Ito, H., Ogura, M. and Kagami, Y. (2003) Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma. Haematologica, 88, pp. 159-166.
11. Krajinovic, M., Costea, I. and Chiasson, S. (2002) Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia. Lancet, 359, pp. 1033-1034.
12. Iacopetta, B., Grieu, F., Joseph, D. and Elsaleh, H. (2001) A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer, 85, pp. 827-830.
13. Leclerc, D., Campeau, E., Goyette, P., Adjalla, C. E., Christensen, B. and Ross, M. (1996) Human methionine synthase: CDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Hum Mol Genet, 5, pp. 1867-1874.
14. Harmon, D. L., Shields, D. C., Woodside, J. V., McMaster, D., Yarnell, J. W. and Young, I. S. (1999) Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet Epidemiol, 17, pp. 298-309.
15. Gaughan, D. J., Kluijtmans, L. A., Barbaux, S., McMaster, D., Young, I. S. and Yarnell, J. W. (2001) The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma homocysteine concentrations. Atherosclerosis, 157, pp. 451-456.
16. Jacques, P. F., Bostom, A. G., Selhub, J., Rich, S., Ellison, R. C. and Eckfeldt, J. H. (2003) Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis, 166, pp. 49-55.
17. Lincz, L. F., Scorgie, F. E., Kerridge, I., Potts, R., Spencer, A. and Enno, A. (2003) Methionine synthase genetic polymorphism MS A2756G alters susceptibility to follicular but not diffuse large B-cell non-Hodgkin's lymphoma or multiple myeloma. Br J Haematol, 120, pp. 1051-1054.
18. Gemmati, D., Ongaro, A., Scapoli, G. L., Della Porta, M., Tognazzo, S. and Serino, M. L. (2004) Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prev, 13, pp. 787-794.
19. Gadner, H., Masera, G., Schrappe, M., Eden, T., Benoit, Y. and Harrison, C. (2006) The 8th International Childhood Acute Lymphoblastic Leukemia Workshop ('Ponte di legno meeting'), Vienna, Austria, April 27-28, 2005. Leukemia, 20, pp. 9-17.
20. Miller, S. A., Dykes, D. D. and Polesky, H. F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res, 16, p. 1215.
21. Pogribny, I. and James, S Jill (2002) Multiplex PCR for simultaneous detection of 677 C → T and 1298 A → C polymorphisms in methylenetetrahydrofolate reductase gene for population studies of cancer risk. Cancer Lett, 181, p. 209.
22. Matsuo, K., Suzuki, R., Hamajima, N., Ogura, M., Kagami, Y. and Taji, H. (2001) Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood, 97, pp. 3205-3209.
23. Lightfoot, T. J., Skibola, C. F., Willett, E. V., Skibola, D. R., Allan, J. M. and Coppede, F. (2005) Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes. Cancer Epidemiol Biomarkers Prev, 14, pp. 2999-3003.
24. Skibola, C. F., Forrest, M. S., Coppede, F., Agana, L., Hubbard, A. and Smith, M. T. (2004) Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. Blood, 104, pp. 2155-2162.
25. Franco, R. F., Simoes, B. P., Tone, L. G., Gabellini, S. M., Zago, M. A. and Falcao, R. P. (2001) The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol, 115, pp. 616-618.
26. Wiemels, J. L., Smith, R. N., Taylor, G. M., Eden, O. B., Alexander, F. E. and Greaves, M. F. (2001) Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA, 98, pp. 4004-4009.
27. Balta, G., Yuksek, N., Ozyurek, E., Ertem, U., Hicsonmez, G. and Altay, C. (2003) Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol, 73, pp. 154-160.
28. Oliveira, E., Alves, S., Quental, S., Ferreira, F., Norton, L. and Costa, V. (2005) The MTHFR C677T and A1298C polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in Portugal. J Pediatr Hematol Oncol, 27, pp. 425-429.
29. Schnakenberg, E., Mehles, A., Cario, G., Rehe, K., Seidemann, K. and Schlegelberger, B. (2005) Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet, 6, p. 23.
30. Pereira, T. V., Rudnicki, M., Pereira, A. C., Pombo-de-Oliveira, M. S. and Franco, R. F. (2006) 5,10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis. Cancer Epidemiol Biomarkers Prev, 15, pp. 1956-1963.
31. Bender, C. M., Pao, M. M. and Jones, P. A. (1998) Inhibition of DNA methylation by 5-aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res, 58, pp. 95-101.
32. Vidan-Jeras, B., Jurca, B., Dolzan, V., Jeras, M., Breskvar, K. and Bohinjec, M. (1998) Caucasian Slovenian normal. HLA 1998, pp. 180-181. American society for histocompatibility and immunogenetics, Lenexa
33. Faria-Neto, J. R., Chagas, A. C., Bydlowski, S. P., Neto, P A Lemos, Chamone, D. A. and Ramirez, J. A. (2006) Hyperhomocystinemia in patients with coronary artery disease. Braz J Med Biol Res, 39, pp. 455-463.
34. Meglic, L., Stegnar, M., Milanez, T., Bozic, M., Peterlin, B. and Peternel, P. (2003) Factor V Leiden, prothrombin 20210G → A, methylenetetrahydrofolate reductase 677C → T and plasminogen activator inhibitor 4G/5G polymorphism in women with pregnancy-related venous thromboembolism. Eur J Obstet Gynecol Reprod Biol, 111, pp. 157-163.
35. Bohanec, P. and Dolzan, V. (2004) Genetic polymorphisms of enzymes involved in folate metabolism in healthy Slovenian population. Zdrav Vestn, 73, pp. 807-813.